{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:57:53Z","timestamp":1740142673332,"version":"3.37.3"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>Summary Introduction: The association of osmidrosis and hyperhidrosis often causes emotional and social problems that may impair the patients' quality of life. The purpose of our study was to analyze the therapeutic results of oxybutynin and topical agents in 89 patients with both osmidrosis and hyperhidrosis. Method: We conducted an observational study at two specialized centers of hyperhidrosis between April 2007 and August 2013. Eighty-nine (89) patients with both osmidrosis and hyperhidrosis were treated with oxybutynin and topical agents. Patients were evaluated before treatment and at 3 and 6 weeks after treatment started, by using the Quality of Life Questionnaire and the Sweating Evolution Scale. Results: Before treatment, 98% of the patients presented with poor or very poor quality of life. After six weeks of treatment, 70% stated their quality of life as being slightly better or much better (p&lt;0.001) and nearly 70% of the patients experienced a moderate or great improvement in sweating and malodor. Improvement in osmidrosis was significantly greater when the axillary region was the first most disturbing site of hyperhidrosis. Conclusion: There was a significant improvement in quality of life and a reduction in sweating and malodor after six weeks of treatment with topical agents and oxybutynin in patients with both hyperhidrosis and osmidrosis. Therefore, clinical treatment should be considered before invasive techniques.<\/jats:p>","DOI":"10.1590\/1806-9282.64.02.127","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T19:24:20Z","timestamp":1522869860000},"page":"127-132","source":"Crossref","is-referenced-by-count":0,"title":["Combination of topical agents and oxybutynin as a therapeutic modality for patients with both osmidrosis and hyperhidrosis"],"prefix":"10.1590","volume":"64","author":[{"given":"Andrea Yasbek Monteiro","family":"Varella","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-6240","authenticated-orcid":false,"given":"Juliana Maria","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Passos","family":"Teivelis","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Lembran\u00e7a","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia de Almeida","family":"Mendes","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil; Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ribas Milanez de","family":"Campos","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil; Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brazil; Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,2]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000092285","article-title":"Primary focal hyperhidrosis: disease characteristics and functional impairment","volume":"212","author":"Hamm H","year":"2006","journal-title":"Dermatology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/pde.12142","article-title":"Efficacy and quality of life outcomes of oxybutynin for treating palmar hyperhidrosis in children younger than 14 years old","volume":"31","author":"Wolosker N","year":"2014","journal-title":"Pediatr Dermatol"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.avsg.2011.06.007","article-title":"The use of oxybutynin for treating axillary hyperhidrosis","volume":"25","author":"Wolosker N","year":"2011","journal-title":"Ann Vasc Surg"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-4632.2012.05746.x","article-title":"Use of oxybutynin for treating plantar hyperhidrosis","volume":"52","author":"Wolosker N","year":"2013","journal-title":"Int J Dermatol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jvs.2011.07.097","article-title":"Evaluation of quality of life over time among 453 patients with hyperhidrosis submitted to endoscopic thoracic sympathectomy","volume":"55","author":"Wolosker N","year":"2012","journal-title":"J Vasc Surg"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/lap.2006.16.598","article-title":"Axillary hyperhidrosis: T3\/T4 versus T4 thoracic sympathectomy in a series of 276 cases","volume":"16","author":"Campos JRM","year":"2006","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"1","key":"ref7","first-page":"25","article-title":"Impairment in quality of life among patients seeking surgery for hyperhidrosis (excessive sweating) : preliminary results","volume":"37","author":"Amir M","year":"2000","journal-title":"Isr J Psychiatry Relat Sci"},{"issue":"7","key":"ref8","first-page":"497","article-title":"Expression of apolipoprotein D and androgen receptor in axillary osmidrosis and its molecular mechanism","volume":"6","author":"Chen H","year":"2013","journal-title":"Int J Clin Exp Med"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1365-4632.2008.03735.x","article-title":"Etiology and management of axillary bromidrosis: a brief review","volume":"47","author":"Mao GY","year":"2008","journal-title":"Int J Dermatol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000637-200109000-00014","article-title":"What is the best method for treating osmidrosis","volume":"47","author":"Park YJ","year":"2001","journal-title":"Ann Plast Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2156-10-42","article-title":"A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene","volume":"10","author":"Nakano M","year":"2009","journal-title":"BMC Genet"},{"issue":"11","key":"ref12","first-page":"1141","article-title":"Correlation between ABCC11 gene single nucleotide polymorphism and the incidence of axillary osmidrosis in Chinese Han population","volume":"38","author":"Sun Y","year":"2013","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/1346-8138.12115","article-title":"Clinical features of axillary osmidrosis: a retrospective chart review of 723 Japanese patients","volume":"40","author":"Morioka D","year":"2013","journal-title":"J Dermatol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bjps.2004.07.002","article-title":"Treatment for axillary osmidrosis with suction-assisted cartilage shaver","volume":"58","author":"Lee JC","year":"2005","journal-title":"Br J Plast Surg"},{"issue":"8","key":"ref15","first-page":"84","article-title":"Osmidrosis axillae","volume":"34","author":"Nokita M","year":"1970","journal-title":"Kangogaku Zasshi"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1473-2165.2010.00477.x","article-title":"Surgical subcision as a cost-effective and minimally invasive treatment for axillary osmidrosis","volume":"9","author":"Liu Q","year":"2010","journal-title":"J Cosmet Dermatol"},{"issue":"S1","key":"ref17","first-page":"64","article-title":"Axillary hyperhidrosis and osmidrosis treated by ultrasonic surgical aspiration compared with transthoracic endoscopic sympathectomy","volume":"70","author":"Lee HC","year":"2008","journal-title":"Surg Neurol."},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00266-013-0271-5","article-title":"A new osmidrosis procedure, the scrape and suction technique: review of 4,322 patients","volume":"38","author":"Kim HG","year":"2014","journal-title":"Aesthetic Plast Surg"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5021\/ad.2014.26.2.184","article-title":"A prospective, long-term follow-up study of 1,444 nm Nd: YAG Laser: a new modality for treating axillary bromhidrosis","volume":"26","author":"Jung SK","year":"2014","journal-title":"Ann Dermatol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.5999\/aps.2013.40.4.440","article-title":"Minimal subdermal shaving by means of sclerotherapy using absolute ethanol: a new method for the treatment of axillary osmidrosis","volume":"40","author":"Shim HS","year":"2013","journal-title":"Arch Plast Surg"},{"issue":"5","key":"ref21","first-page":"348","article-title":"Comparison study on the efficacy of three methods for the treatment of osmidrosis","volume":"26","author":"Li WW","year":"2010","journal-title":"Zhonghua Zheng Xing Wai Ke Za Zhi"},{"issue":"1","key":"ref22","first-page":"41","article-title":"Correlation between bacterial population and axillary and plantar bromidrosis: study of 30 patients","volume":"10","author":"Guillet G","year":"2000","journal-title":"Eur J Dermatol"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.jvs.2011.12.039","article-title":"A randomized placebo-controlled trial of oxybutynin for the initial treatment of palmar and axillary hyperhidrosis","volume":"55","author":"Wolosker N","year":"2012","journal-title":"J Vasc Surg"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.bjps.2009.05.004","article-title":"Effectiveness and complications of subdermal excision of apocrine glands in 206 cases with axillary osmidrosis","volume":"63","author":"Qian JG","year":"2010","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1 Spec No","key":"ref25","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1111\/j.1524-4725.2006.32334.x","article-title":"An epidemiological study of hyperhidrosis","volume":"33","author":"Lear W","year":"2007","journal-title":"Dermatol Surg."},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1590\/S0365-05962011000300005","article-title":"The use of oxybutynin for treating facial hyperhidrosis","volume":"86","author":"Wolosker N","year":"2011","journal-title":"An Bras Dermatol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1468-3083.2007.02323.x","article-title":"Tumescent superficial liposuction with curettage for treatment of axillary bromhidrosis","volume":"22","author":"Seo SH","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"ref28","first-page":"505","article-title":"Tumescent liposuction with dermal curettage for treatment of axillary osmidrosis and hyperhidrosis","volume":"32","author":"Lee D","year":"2006","journal-title":"Dermatol Surg"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0007-1226(90)90019-V","article-title":"Surgical treatment of axillary osmidrosis","volume":"43","author":"Yoshikata R","year":"1990","journal-title":"Br J Plast Surg"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00000637-199302000-00007","article-title":"Surgical treatment of axillary osmidrosis","volume":"30","author":"Endo T","year":"1993","journal-title":"Ann Plast Surg"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0007-1226(97)91285-6","article-title":"Excision of subcutaneous tissue for the treatment of axillary osmidrosis","volume":"50","author":"Tung TC","year":"1997","journal-title":"Br J Plast Surg"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v64n2\/0104-4230-ramb-64-02-0127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T19:02:25Z","timestamp":1720206145000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302018000200127&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["S0104-42302018000200127"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.64.02.127","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}