{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:15:05Z","timestamp":1782486905989,"version":"3.54.5"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  BACKGROUND: Psoriasis is associated with higher prevalence of metabolic syndrome (MS). The prevalence of MS varies according to the studied population as it suffers influence of genetics, aging, sedentary behaviour and diet.  OBJECTIVE: To study the prevalence of MS in local psoriasis patients and the influence of psoriasis variables on its appearance.  METHODS: A group of 97 psoriasis patients were studied for MS and compared with 97 controls. Psoriasis type, nail involvement, psoriasis extension measured by PASI (Psoriasis Area and Severity Index) were obtained through physical examination and history of previous myocardial infarction, angina and stroke were obtained through chart review.  RESULTS: Comparison of MS prevalence in psoriasis patients (49.4%) with controls (35.0%) showed difference with p=0.04; OR=1.8 (95%CI=1.02-3.23). Patients with psoriasis had higher body mass index (p=0.02), higher systolic blood pressure (p=0.007), lower HDL cholesterol (p=0.01), higher glucose (p=0.04), higher waist circumference (p=0.003) and more angina pectoris (p=0.03;OR=2.5; 95% 0=1.04-6.15) than controls. When psoriasis sample with and without MS were compared, those with MS were older (p=0.0004), had disease onset at older age (p=0.02), more tobacco exposure (p=0.02), and a tendency to have less scalp involvement (p=0.06) in univariate analysis. Logistic regression showed that only age and scalp involvement were independently associated with MS in the psoriasis sample.  CONCLUSION: In our psoriasis sample, MS prevalence is high and the items that deserve more attention are central obesity, low HDL, hypertension and smoking habits. In the psoriasis group, MS was associated independently with older age and less scalp involvement.<\/jats:p>","DOI":"10.1590\/1806-9282.64.04.368","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T17:02:19Z","timestamp":1534611739000},"page":"368-373","source":"Crossref","is-referenced-by-count":25,"title":["Metabolic syndrome and psoriasis: a study in 97 patients"],"prefix":"10.1590","volume":"64","author":[{"given":"Lana Bassi","family":"Ferdinando","sequence":"first","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do PR,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Kaori","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica de Medicina do PR,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sanches","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln Helder Zambaldi","family":"Fabricio","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-3542","authenticated-orcid":false,"given":"Thelma L","family":"Skare","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico de Curitiba,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,4]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5021\/ad.2012.24.1.11","article-title":"Analysis of cardiovascular risk factors and metabolic syndrome in Korean patients with psoriasis","volume":"24","author":"Kim GW","year":"2012","journal-title":"Ann Dermatol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaad.2012.08.015","article-title":"Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies","volume":"68","author":"Armstrong AW","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4103\/0019-5154.100474","article-title":"Prevalence of metabolic syndrome in South Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: a hospital-based case-control study","volume":"57","author":"Madanagobalane S","year":"2012","journal-title":"Indian J Dermatol"},{"issue":"16","key":"ref4","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti KG","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.0000055014.62083.05","article-title":"C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women","volume":"107","author":"Ridker PM","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.CIR.102.1.42","article-title":"Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)","volume":"102","author":"Festa A","year":"2000","journal-title":"Circulation"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00125-014-3453-z","article-title":"Dose-response relationships between sedentary behavior and the metabolic syndrome and its components","volume":"58","author":"Gennuso KP","year":"2015","journal-title":"Diabetologia"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/archinte.163.4.427","article-title":"The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994","volume":"163","author":"Park YW","year":"2003","journal-title":"Arch Intern Med"},{"issue":"5 Suppl 93","key":"ref9","first-page":"S14","article-title":"The skin in psoriasis: assessment and challenges. 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