{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:27:41Z","timestamp":1765888061516,"version":"3.37.3"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  AIM: the present study analysed the association between Zika-virus and microcephaly during the gestational period of women in Brazil.  Methodology: Systematic reviews of intervention research, current publications of clinical investigations were used systematic search strategies in three electronic databases PubMed, SciELO and Google academic. The following keywords were used: Microcephaly, gestation, Zika-virus to perform the search, and 1020 articles were obtained after exclusion, 45 were left and 35 were eligible. The collection period was from 2004 to 2017.  Results: Epidemiological data suggest a temporal association between the quantitative increase and the Zika-virus epidemic, especially in Northeast Brazil. It is not consensual to measure the cephalic perimeter curve to be considered.  Conclusion: Given this, the application of techniques to accurately diagnose the relationship between causes and effects in the pathogenesis of Zika virus infection in the central nervous system should be prioritized.<\/jats:p>","DOI":"10.1590\/1806-9282.64.07.635","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T09:31:17Z","timestamp":1539941477000},"page":"635-642","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between microcephaly and Zika virus during pregnancy: a review"],"prefix":"10.1590","volume":"64","author":[{"given":"Gerusinete Rodrigues Bastos dos","family":"Santos","sequence":"first","affiliation":[{"name":"Federal University of Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-0988","authenticated-orcid":false,"given":"Francisca Bruna Arruda","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Federal University of Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walder Jansen de Mello","family":"Lob\u00e3o","sequence":"additional","affiliation":[{"name":"UFMA,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano Ros\u00e1rio","family":"Lima","sequence":"additional","affiliation":[{"name":"Family Health Strategy,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa Marillac Ramos Lacerda de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Federal University of Maranh\u00e3o,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quesia Rodrigues","family":"Furtado","sequence":"additional","affiliation":[{"name":",  Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo","family":"Batista","sequence":"additional","affiliation":[{"name":"Federal University of Maranhao,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,7]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3201\/eid2110.151125","article-title":"Zika Virus transmission from French Polynesia to Brazil","volume":"21","author":"Musso D","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"ref2","first-page":"06","article-title":"Vieira: a pluma e a voz","volume":"26","author":"Negras L","year":"2016","journal-title":"Letras"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15585\/mmwr.mm6503e2","article-title":"Possible association between zika virus infection and microcephaly - Brazil, 2015","volume":"65","author":"Schuler-Faccini L","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7588","key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nature.2016.19259","article-title":"Zika virus: Brazil's surge in small-headed babies questioned by report","volume":"530","author":"Butler D","year":"2016","journal-title":"Nature"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. 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