{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:28:44Z","timestamp":1747301324813,"version":"3.37.3"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  To evaluate the survival of patients with brain metastases treated surgically according to the potentially involved factors.  METHODS  71 patients treated surgically were analyzed with the diagnosis of brain metastases during the period from January 2011 to November 2014, totaling 47 months of follow-up. The Kaplan-Meier curve method was used for survival analysis.  Results  We evaluated 71 patients with brain metastases treated surgically, 44 female and 27 male, mean age of 60.1 years. According to the Karnofsky scale, 44 patients were classified with Karnofsky greater than or equal to 70 and 27 patients with Karnofsky inferior to 70. Lung was the primary site most commonly found. Death occurred in twenty patients (28%), and lung tumors were responsible for the most deaths. Twelve patients had supra and infratentorial metastases, fifty-nine only had supratentorial lesions, and lesions were multiple in twenty-eight patients and single in forty-three. Thirty patients were also treated with chemotherapy, eighteen with chemotherapy and radiation therapy, while only three received just radiotherapy. Survival analysis by Kaplan-Meier curve showed no statistical significance regarding age, histological type, location, Karnofsky, chemotherapy, and radiotherapy. There was statistical significance regarding gender.  CONCLUSION  The factors analyzed did not change survival rates, except for gender. This fact may probably be explained due to the systemic and diffuse behavior of cancer.<\/jats:p>","DOI":"10.1590\/1806-9282.64.08.717","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T18:12:52Z","timestamp":1543083172000},"page":"717-722","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of survival in patients with brain metastases treated surgically: Impact of age, gender, oncologic status, chemotherapy, radiotherapy, number and localization of lesions, and primary cancer site"],"prefix":"10.1590","volume":"64","author":[{"given":"Jos\u00e9 Marcus","family":"Rotta","sequence":"first","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella Brito","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliete Melo","family":"Diniz","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Medeiros de","family":"Abreu","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulysses Oliveira","family":"Sousa","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Vieira","family":"Botelho","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-7583","authenticated-orcid":false,"given":"Matheus Fernandes de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Public Servant\u2019s Hospital of the State of S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,8]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11060-007-9510-4","article-title":"Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial","volume":"87","author":"Muacevic A","year":"2008","journal-title":"J Neurooncol"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1001\/jama.296.17.2089","article-title":"Radiosurgery plus whole-brain radiation therapy for brain metastases","volume":"296","author":"Patchell RA","year":"2006","journal-title":"JAMA"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3171\/JNS\/2008\/108\/2\/0248","article-title":"Comparative risk of leptomeningeal disease after resection or stereotactic radiosurgery for solid tumor metastasis to the posterior fossa","volume":"108","author":"Suki D","year":"2008","journal-title":"J Neurosurg"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ana.410330605","article-title":"Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?","volume":"33","author":"Vecht CJ","year":"1993","journal-title":"Ann 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Ther"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","article-title":"Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study","volume":"29","author":"Kocher M","year":"2011","journal-title":"J Clin Oncol"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0971-5851.158835","article-title":"Management of solitary and multiple brain metastases from breast cancer","volume":"36","author":"Willett A","year":"2015","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"3","key":"ref14","article-title":"Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases","author":"Soon YY","year":"2014","journal-title":"Cochrane Database Syst 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