{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:34:42Z","timestamp":1774265682049,"version":"3.50.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  PURPOSE: To investigate the contribution of the deletion polymorphism and insertion (rs1799752) of the angiotensin converting enzyme (ACE) gene in the aetiology of Polycystic Ovarian Syndrome (PCOS).  METHODOLOGY: 97 women diagnosed with PCOS who received care at the Gynaecology and Obstetrics clinic of the Hospital das Cl\u00ednicas of UFTM, participated in this study. The control group consisted of 94 women. All participants were submitted to the collection of 10 mL of whole blood and the genomic DNA was obtained by the saline extraction method. The genotyping of the samples was performed by means of the Polymerase Chain Reaction (PCR). The statistics analyses were performed by descriptive analysis, univariate analysis and logistic regression model. The results were presented in odds ratio (OR) and confidence interval of 95% (CI-95%), with a significance level of 5% (p\u22640.05).  RESULTS: There were no statistical differences between patients and controls for the genotypic (\u03c72 = 1.52, p = 0.47) and allelic frequencies (\u03c72 = 0.21, p = 0.76). The distribution of the genotypic frequency is not in HWE for patients (\u03c72 = 18.80, p &lt;0.05) and for controls (\u03c72 = 6.85, p &lt;0.05). In relation to the risk factors for the syndrome, the history of familial PCOS is more frequent between women with the syndrome.  CONCLUSION: In the study population, there was no association between I\/D polymorphism of the ACE gene and PCOS.<\/jats:p>","DOI":"10.1590\/1806-9282.64.11.1017","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T13:48:56Z","timestamp":1544881736000},"page":"1017-1022","source":"Crossref","is-referenced-by-count":9,"title":["Polycystic ovarian syndrome: rs1799752 polymorphism of ACE gene"],"prefix":"10.1590","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-805X","authenticated-orcid":false,"given":"Mariangela Torreglosa Ruiz","family":"Cintra","sequence":"first","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marly Aparecida Spadotto","family":"Balarin","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Cristina Sato Vaz","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Iorrana Mota da","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra Bernadete Trov\u00f3 de","family":"Marqui","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete Aparecida Mantovani Rodrigues de","family":"Resende","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco F\u00e1bio Prata","family":"Lima","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Kef\u00e1las Oliveira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Federal University of Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,11]]},"reference":[{"issue":"1","key":"ref1","first-page":"17","article-title":"Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH","volume":"18","author":"Bani Mohammad M","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1590\/1806-9282.62.09.867","article-title":"Current aspects of polycystic ovary syndrome: a literature review","volume":"62","author":"Andrade VH","year":"2016","journal-title":"Rev Assoc Med Bras"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12958-016-0173-x","article-title":"Genetic, hormonal 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