{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:17:48Z","timestamp":1774945068457,"version":"3.50.1"},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE In this study, we intend to identify the prevalence of clinical variables in children with microcephaly.  METHODS This is a cross-sectional and observational study with data collected from medical records of patients admitted to the microcephaly outpatient clinic of a referral center in Teresina-PI. Demographic (gender and age) and clinical data (presence of epilepsy, dysphagia, irritability, and associated comorbidities) were collected. The frequency of Zika virus as a probable etiology was determined from computed tomography patterns and the exclusion of other etiologies by serological tests.  RESULTS A total of 67 patient records were evaluated, of which 31 were male and 36 were female, with a mean age of 1 year and 10 months. The most prevalent clinical variables were epilepsy, present in 47 children (70.2%), and irritability in 37 (55.2%). Also with a high frequency, 22 had dysphagia (32.8%), and 13 had musculoskeletal comorbidities (19.4%). Only three patients in the sample had cardiac abnormalities (4.5%), and no endocrine comorbidity was found. A total of 38 children in the sample (56.7%) presented ZIKV as a probable etiology and, in these cases, there was a higher frequency of epilepsy and dysphagia compared to other etiologies, although not statistically significant.  CONCLUSION Epilepsy, irritability, dysphagia, and musculoskeletal comorbidities were the most frequent clinical variables in children with microcephaly. There was a high prevalence of congenital ZIKV microcephaly syndrome in this sample.<\/jats:p>","DOI":"10.1590\/1806-9282.65.10.1249","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T19:32:49Z","timestamp":1573068769000},"page":"1249-1253","source":"Crossref","is-referenced-by-count":10,"title":["Clinical aspects of congenital microcephaly syndrome by Zika virus in a rehabilitation center for patients with microcephaly"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-7323","authenticated-orcid":false,"given":"Kelson James","family":"Almeida","sequence":"first","affiliation":[{"name":"Centro Integrado de Reabilita\u00e7\u00e3o,  Brasil; Facid\/Wyden,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-0705","authenticated-orcid":false,"given":"Augusto C\u00e9sar Beserra","family":"Martins","sequence":"additional","affiliation":[{"name":"Facid\/Wyden,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-9425","authenticated-orcid":false,"given":"Isadora Costa Coelho Gayoso e","family":"Almendra","sequence":"additional","affiliation":[{"name":"Facid\/Wyden,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0812-4246","authenticated-orcid":false,"given":"Gabriel Medina Sobreira de","family":"Meneses","sequence":"additional","affiliation":[{"name":"Universidade Federal de Piau\u00ed,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4819-883X","authenticated-orcid":false,"given":"Thales Daniel de Oliveira","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Facid\/Wyden,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-0129","authenticated-orcid":false,"given":"Jos\u00e9 da Cruz Moura","family":"Camp\u00ealo","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Uninovafapi,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-8974","authenticated-orcid":false,"given":"Edson","family":"Bor-Seng-Shu","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,10]]},"reference":[{"issue":"8","key":"ref1","first-page":"680","article-title":"Measuring head circumference: update on infant microcephaly","volume":"61","author":"Harris SR","year":"2015","journal-title":"Can Fam Physician"},{"issue":"6","key":"ref2","article-title":"Microcephaly","volume":"4","author":"Hanzlik 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two-center study and review of the literature","volume":"56","author":"von der Hagen M","year":"2014","journal-title":"Dev Med Child Neurol"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3201\/eid2211.160956","article-title":"Early growth and neurologic outcomes of infants with probable congenital Zika virus syndrome","volume":"22","author":"Moura da Silva AA","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1590\/1806-9304201600s100003","article-title":"Epileptic seizures in children with congenital Zika virus syndrome","volume":"16","author":"Alves LV","year":"2016","journal-title":"Rev Bras Sa\u00fade Mater Infant"},{"issue":"3","key":"ref9","article-title":"Cardiac findings in infants with in utero exposure to Zika virus: a cross sectional study","volume":"12","author":"Orofino DHG","year":"2018","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Revista da 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