{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:42:39Z","timestamp":1790858559683,"version":"4.1.0"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  Evaluate the expression of KI-67 in uterine leiomyomas and adjacent myometrial tissue and verify the existence of a correlation between clinical parameters and KI-67 expression in tumors.  METHODS  This is a cross-sectional, controlled, analytical study. Samples of leiomyomas and myometrium were obtained from patients who underwent hysterectomy. The samples were processed by immunohistochemistry using KI-67 antibody, and the expression was evaluated by two blinded observers. Student\u203as T-test was used for comparison of means, and Pearson\u203as P test for correlation with clinical parameters.  RESULTS  A total of 9 patients were included in the study. The mean age was 40.7 years, ranging from 35 to 44 years. The mean expression of KI-67 in myometrium was 1.63%, and, in leiomyomas, 5.96% (p &lt;0.001). The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level.  CONCLUSION  The expression of KI-67 in normal myometrium was significantly lower than in leiomyomas. The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level in the patients of this study.<\/jats:p>","DOI":"10.1590\/1806-9282.65.12.1459","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T12:56:32Z","timestamp":1579870592000},"page":"1459-1463","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of KI-67 expression in uterine leiomyoma and in healthy myometrium: a pilot study"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-4123","authenticated-orcid":false,"given":"Walberto Monteiro Neiva","family":"Eul\u00e1lio Filho","sequence":"first","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil; Universidade Federal do Piau\u00ed,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-9607","authenticated-orcid":false,"given":"Eduardo Augusto Sousa","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil; Universidade Federal do Piau\u00ed,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-6683","authenticated-orcid":false,"given":"Maria Simone Oliveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-8220","authenticated-orcid":false,"given":"Emerson Davi do Nascimento","family":"Brazil","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-7846","authenticated-orcid":false,"given":"Rodolfo Myronn de Melo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-9655","authenticated-orcid":false,"given":"Rubens Moura Campos","family":"Zeron","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Santos,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-7538","authenticated-orcid":false,"given":"Benedito Borges","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil; Hospital Get\u00falio Vargas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-4352","authenticated-orcid":false,"given":"Pedro Vitor Lopes","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brasil; Universidade Federal do Piau\u00ed,  Brasil; Hospital Get\u00falio Vargas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,12]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humupd\/dmv030","article-title":"Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth","volume":"21","author":"Commandeur AE","year":"2015","journal-title":"Hum Reprod Update"},{"issue":"3","key":"ref2","first-page":"173","article-title":"Leiomiomatosis uterina. Aspectos epidemiol\u00f3gicos, fisiopatog\u00e9nicos, reproductivos, cl\u00ednicos y terap\u00eauticos","volume":"80","author":"Vargas-Hern\u00e1ndez VM","year":"2013","journal-title":"Rev Hosp Jua Mex"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1590\/S1415-790X2013000200007","article-title":"Preval\u00eancia de diagn\u00f3stico m\u00e9dico auto-relatado de miomas uterinos em popula\u00e7\u00e3o brasileira: padr\u00f5es demogr\u00e1ficos e socioecon\u00f4micos no Estudo Pr\u00f3-Sa\u00fade","volume":"16","author":"Boclin KLS","year":"2013","journal-title":"Rev Bras Epidemiol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/GRF.0000000000000164","article-title":"Epidemiology of uterine fibroids: from menarche to menopause","volume":"59","author":"Wise LA","year":"2016","journal-title":"Clin Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2015.11.018","article-title":"The epidemiology and genetics of uterine leiomyoma","volume":"34","author":"Styer AK","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"24","key":"ref6","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1093\/jnci\/djt306","article-title":"An international Ki67 reproducibility study","volume":"105","author":"Polley MY","year":"2013","journal-title":"J Natl Cancer Inst"},{"issue":"22","key":"ref7","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/jnci\/djr393","article-title":"Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer Working Group","volume":"103","author":"Dowsett M","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"ref8","first-page":"93","article-title":"Expression of Ki-67, P53 and progesterone receptors in uterine smooth muscle tumors. Diagnostic value","volume":"34","author":"Petrovi\u0107 D","year":"2010","journal-title":"Coll Antropol"},{"issue":"3","key":"ref9","first-page":"1129","article-title":"Immunohistochemical analysis in the diagnosis of uterine myometrial smooth muscle tumors","volume":"55","author":"St\u0103nescu AD","year":"2014","journal-title":"Rom J Morphol Embryol"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/PAS.0b013e318287779c","article-title":"Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up","volume":"37","author":"Mills AM","year":"2013","journal-title":"Am J Surg Pathol"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v65n12\/1806-9282-ramb-65-12-1459.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T08:57:17Z","timestamp":1611392237000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302019001201459&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["S0104-42302019001201459"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.65.12.1459","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}