{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:16Z","timestamp":1787793856200,"version":"build-2784847793"},"reference-count":11,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY Eosinophilic fasciitis, or Shulman's disease, is a rare disease of unknown etiology. It is characterized by peripheral eosinophilia, hypergammaglobulinemia, and high erythrocyte sedimentation rate. The diagnosis is confirmed by a deep biopsy of the skin. The first line of treatment is corticotherapy. We present a rare case of eosinophilic fasciitis in a 27-year-old woman with an atypical presentation with symmetrical peripheral edema and a Groove sign. The patient responded well to treatment with corticosteroids at high doses and, in this context, was associated with hydroxychloroquine and azathioprine. After two and a half years, peripheral eosinophilia had increased, and more of her skin had hardened. At that time, the therapy was modified to include corticoids, methotrexate, and penicillamine. It is of great importance to publicize these cases that allow us to gather experience and better treat our patients.<\/jats:p>","DOI":"10.1590\/1806-9282.65.3.326","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:29:46Z","timestamp":1555003786000},"page":"326-329","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic fasciitis: an atypical presentation of a rare disease"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6186","authenticated-orcid":false,"given":"Catia","family":"Cabral","sequence":"first","affiliation":[{"name":"Centro Hospitalar Tondela-Viseu,  Portugal; Hospital de Braga,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3144-6630","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Novais","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Tondela-Viseu,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-2764","authenticated-orcid":false,"given":"David","family":"Araujo","sequence":"additional","affiliation":[{"name":"Hospital de Braga,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-0072","authenticated-orcid":false,"given":"Ana","family":"Mosca","sequence":"additional","affiliation":[{"name":"Hospital de Braga,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-4673","authenticated-orcid":false,"given":"Ana","family":"Lages","sequence":"additional","affiliation":[{"name":"Hospital de Braga,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-422X","authenticated-orcid":false,"given":"Anna","family":"Knock","sequence":"additional","affiliation":[{"name":"Hospital de Braga,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,3]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5021\/ad.2011.23.1.81","article-title":"Two cases of eosinophilic fasciitis","volume":"23","author":"Chun JH","year":"2011","journal-title":"Ann Dermatol"},{"issue":"2","key":"ref2","first-page":"107","article-title":"Fasci\u00edte eosinof\u00edlica: relato de caso","volume":"62","author":"Massarente VL","year":"2017","journal-title":"Arq Med Hosp Fac Cienc Med Santa Casa S\u00e3o Paulo"},{"issue":"1","key":"ref3","first-page":"120","article-title":"Fasce\u00edte eosinof\u00edlica e aplasia medular. Acta Reumatol","volume":"34","author":"Falc\u00e3o S","year":"2009","journal-title":"Port"},{"key":"ref4","first-page":"70","article-title":"Diffuse fasciitis with eosinophilia: a new syndrome?","volume":"88","author":"Shulman LE","year":"1975","journal-title":"Trans Assoc Am Physicians"},{"issue":"9 Suppl 2","key":"ref5","first-page":"36","article-title":"Atypical presentation of eosinophilic fasciitis with pitting edema","volume":"74","author":"Chang CW","year":"2015","journal-title":"Hawaii J Med Public Health"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-4632.2007.03544.x","article-title":"Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature","volume":"47","author":"Bischoff L","year":"2008","journal-title":"Int J Dermatol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/rheumatology\/ker366","article-title":"Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients","volume":"51","author":"Lebeaux D","year":"2012","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2214\/ajr.184.3.01840975","article-title":"Eosinophilic fasciitis: spectrum of MRI findings","volume":"184","author":"Moulton SJ","year":"2005","journal-title":"AJR Am J Roentgenol"},{"issue":"5 suppl 1","key":"ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1590\/abd1806-4841.20164683","article-title":"Eosinophilic fasciitis","volume":"91","author":"Lamback EB","year":"2016","journal-title":"An Bras Dermatol"},{"key":"ref10","first-page":"716935","article-title":"Eosinophilic fasciitis: a rare skin sclerosis","volume":"2011","author":"Servy A","year":"2011","journal-title":"Patholog Res Int"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10067-011-1866-3","article-title":"D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature","volume":"31","author":"Manzini CU","year":"2012","journal-title":"Clin Rheumatol"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v65n3\/1806-9282-ramb-65-03-0326.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T11:09:18Z","timestamp":1581419358000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302019000300326&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["S0104-42302019000300326"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.65.3.326","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}