{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:10:47Z","timestamp":1790881847185,"version":"4.1.0"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  BACKGROUND: There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence.  OBJECTIVE: This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment.  METHODS: The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Subclinical atherosclerosis markers were evaluated using ultrasonography, tomography, and exercise stress test. Plasma concentrations of TNF\u03b1, IL-1\u03b2, IL-6, and BDNF were measured using Luminex100\u2122. The usCRP concentration was measured using turbidimetric immunoassay. IL1B, IL6, and TNFA expression were determined using TaqMan\u00ae. For the statistical analysis, the significance level was established at p&lt;0.05.  RESULTS: Concerning subclinical atherosclerosis markers, only O2 consumption was reduced in the BAD group (p = 0.001). Although no differences were found in gene expression, BDNF and IL-1\u03b2 plasma concentration was increased in the RD group (p = 0.002 and p = 0.005, respectively) even with an antidepressant treatment, which suggests that these drugs have no effect in IL-1\u03b2 secretion and that the inflammasome may play a role in therapy response.  CONCLUSION: Taken together, both BDNF and IL-1\u03b2 plasma concentrations could be used to the early identification of RD patients.<\/jats:p>","DOI":"10.1590\/1806-9282.65.3.361","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T20:45:23Z","timestamp":1554929123000},"page":"361-369","source":"Crossref","is-referenced-by-count":33,"title":["Increased levels of plasma IL-1b and BDNF can predict resistant depression patients"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-9881","authenticated-orcid":false,"given":"Luciana","family":"Uint","sequence":"first","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-9811","authenticated-orcid":false,"given":"Gisele Medeiros","family":"Bastos","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-3647","authenticated-orcid":false,"given":"Helena Strelow","family":"Thurow","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-0132","authenticated-orcid":false,"given":"Jessica Bassani","family":"Borges","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology,  Brasil; University of S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-8121","authenticated-orcid":false,"given":"Thiago Dominguez Crespo","family":"Hirata","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  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