{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:20Z","timestamp":1759336280155,"version":"3.37.3"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: CT perfusion (CTP) is an imaging technique that can be used to evaluate the changes in the microcirculation of tumor tissues. Our study aimed to investigate the role of CTP in predicting mediastinal lymph node metastasis.  METHODS: Clinical data of 58 patients who received surgical resection of lung cancer and lymph node dissection in our hospital from June 2012 to December 2014 were collected. Patients were divided into a positive lymph node metastasis group and a negative lymph node metastasis group. Parameters of CTP, including peak enhancement intensity (PEI), perfusion value (PV), as well as blood volume (BV), were compared between the two groups. The receiver-operating characteristic (ROC) curve was used to predict mediastinal lymph node metastasis.  RESULTS: The PV of the positive lymph node metastasis group was significantly higher than that of the negative group (p &lt; 0.001). The ROC curve analysis showed that PV can be used as an index to predict mediastinal lymph node metastasis of lung cancer. The sensitivity and specificity of a PV greater than 7.5ml\u00b7min-1\u00b7ml-1 in predicting lymph node metastasis of lung cancer were 78.3 % and 91.4 %, respectively.  CONCLUSION: The PV of low dose CT perfusion can be used as an index for predicting mediastinal lymph node metastasis of lung cancer.<\/jats:p>","DOI":"10.1590\/1806-9282.65.6.761","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T15:06:53Z","timestamp":1563635213000},"page":"761-766","source":"Crossref","is-referenced-by-count":2,"title":["Role of low dose 256-slice CT perfusion imaging in predicting mediastinal lymph node metastasis of lung cancer"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-8994","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Shandong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-0553","authenticated-orcid":false,"given":"Lu","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-7386","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":",  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-2697","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,6]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel RL","year":"2016","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/annonc\/mdx033","article-title":"European cancer mortality predictions for the year 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survival after resection of non-small cell lung cancer","volume":"102","author":"Smeltzer MP","year":"2016","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1245\/s10434-011-2210-5","article-title":"Diagnostic accuracy of MRI for assessment of T category, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer: a systematic review and meta-analysis","volume":"19","author":"Al-Sukhni E","year":"2012","journal-title":"Ann Surg Oncol"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v65n6\/1806-9282-ramb-65-06-0761.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T15:42:15Z","timestamp":1581090135000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302019000600761&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["S0104-42302019000600761"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.65.6.761","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}