{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:54:31Z","timestamp":1761630871856,"version":"3.37.3"},"reference-count":83,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY OBJECTIVE: The objective of this review was to investigate the epidemiology of Fulminant Acute Hepatitis in Latin America and the Caribbean and identify possible measures aimed at a better understanding and improvement of patient support. METHODS: We used 3 different researchers to investigate the topic of Fulminant Acute Hepatitis in pediatrics in papers published by Latin American and Caribbean authors in the PubMed and SciELO databases from 2000 to 2016. RESULTS: We found 2,879 articles in the databases searched. After selecting and excluding articles according to the study protocol, 68 remaining studies were obtained for analysis. A total of 1,265 cases of acute fulminant hepatitis were detected, with a predominance of females (42.9%), followed by males (39.4%), with no description of sex in 17.7% of the cases. The main cause was viral hepatitis, representing 45.1% of the cases. The hepatitis A virus was responsible for 34.7% of the total cases and 76.9% of the infectious causes. Of the total number of patients, 26.9% were described as idiopathic, and 11.5% had no cause. CONCLUSION: The preventable causes of Fulminant Acute Hepatitis include hepatitis viruses - primarily the hepatitis A virus - and poisoning. Active vaccination, basic sanitation, and public awareness can reduce the number of patients and, consequently, the costs of liver transplantation due to these causes.<\/jats:p>","DOI":"10.1590\/1806-9282.65.6.914","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T19:05:29Z","timestamp":1563649529000},"page":"914-921","source":"Crossref","is-referenced-by-count":9,"title":["Fulminant acute hepatitis in pediatrics in Latin America and the Caribbean"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6734-5765","authenticated-orcid":false,"given":"Jos\u00e9","family":"Colleti Junior","sequence":"first","affiliation":[{"name":"Santa Catarina Hospital, Brasil; Assun\u00e7\u00e3o Hospital, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2729-0602","authenticated-orcid":false,"given":"Felipe Rezende","family":"Caino","sequence":"additional","affiliation":[{"name":"Santa Catarina Hospital, Brasil; Institute of Pediatric Oncology, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-6837","authenticated-orcid":false,"given":"Rafael","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Oncology, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-616X","authenticated-orcid":false,"given":"Werther Brunow de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,6]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4037\/aacnacc2016324","article-title":"Acute liver failure","volume":"27","author":"Grek A","year":"2016","journal-title":"AACN Adv Crit Care"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.20703","article-title":"American Association for the Study of Liver Disease. AASLD position paper: the management of acute liver failure","volume":"41","author":"Polson J","year":"2005","journal-title":"Hepatology"},{"issue":"8866","key":"ref3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0140-6736(93)91818-7","article-title":"Acute liver failure: redefining the syndromes","volume":"342","author":"O'Grady JG","year":"1993","journal-title":"Lancet"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jpeds.2005.12.051","article-title":"Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group","volume":"148","author":"Squires Jr RH","year":"2006","journal-title":"J Pediatr"},{"issue":"6-7","key":"ref5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.clinre.2011.03.005","article-title":"Acute liver failure in children","volume":"35","author":"Devictor D","year":"2011","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"9736","key":"ref6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"Bernal W","year":"2010","journal-title":"Lancet"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1399-3046.2010.01356.x","article-title":"Improved outcomes in pediatric liver transplantation for acute liver failure","volume":"14","author":"Miloh T","year":"2010","journal-title":"Pediatr Transplant"},{"issue":"4","key":"ref8","first-page":"1401","article-title":"Acute liver failure: Summary of a workshop","volume":"47","author":"Lee WM","year":"2008","journal-title":"Hepatology"},{"year":"2016","series-title":"Human development report 2016: Human development for everyone","key":"ref9"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1590\/S0037-86822002000500010","article-title":"Acute liver failure in children: observations in Vit\u00f3ria, Esp\u00edrito Santo State, Brasil","volume":"35","author":"Moreira-Silva SF","year":"2002","journal-title":"Rev Soc Bras Med Trop"},{"issue":"4","key":"ref11","first-page":"245","article-title":"Autoimmune hepatitis in children. Initial presentation as fulminant hepatic failure","volume":"30","author":"Cuarterolo M","year":"2000","journal-title":"Acta Gastroenterol Latinoam"},{"issue":"1","key":"ref12","first-page":"72","article-title":"Isoniazid-induced hepatic failure. Report of a case","volume":"37","author":"Pereira RM","year":"2000","journal-title":"Arq Gastroenterol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.37757\/MR2015.V17.N1.10","article-title":"Acute liver failure in Cuban children","volume":"17","author":"Silverio CE","year":"2015","journal-title":"MEDICC Rev"},{"issue":"2","key":"ref14","first-page":"178","article-title":"Acute lymphatic leukemia presenting in fatal fulminant hepatitis","volume":"74","author":"Suso A","year":"2014","journal-title":"Medicina (B Aires)"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcv.2014.03.008","article-title":"Acute liver failure in an immunocompetent patient","volume":"60","author":"Paula VS","year":"2014","journal-title":"J Clin Virol"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1016\/j.transproceed.2013.08.078","article-title":"Pediatric liver transplant outcome using severe hypernatremic donors","volume":"45","author":"Uribe M","year":"2013","journal-title":"Transplant Proc"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1016\/j.transproceed.2013.08.090","article-title":"Pediatric liver transplantation experience and outcome in Chile","volume":"45","author":"Acu\u00f1a C","year":"2013","journal-title":"Transplant Proc"},{"issue":"7","key":"ref18","first-page":"463","article-title":"Acute liver failure due to diffuse large B-cell lymphoma","volume":"36","author":"Mu\u00f1oz O","year":"2013","journal-title":"Gastroenterol Hepatol"},{"issue":"3","key":"ref19","first-page":"e35","article-title":"Fulminant hepatic failure due to tuberculostatic drugs: case report","volume":"110","author":"Malla I","year":"2012","journal-title":"Arch Argent Pediatr"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MPG.0b013e3182349a04","article-title":"Pediatric end-stage liver disease score in acute liver failure to assess poor prognosis","volume":"54","author":"Sanchez MC","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.transproceed.2010.11.013","article-title":"Living related donor liver transplantation in children","volume":"43","author":"Tannuri AC","year":"2011","journal-title":"Transplant Proc"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1590\/S1413-86702009000500002","article-title":"Fulminant hepatitis failure in adults and children from a Public Hospital in Rio de Janeiro, Brasil","volume":"13","author":"Santos DC","year":"2009","journal-title":"Braz J Infect Dis"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/INF.0b013e3181d3ce4c","article-title":"Acute liver failure associated with rubella virus in a child","volume":"29","author":"Figueiredo CA","year":"2010","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.transproceed.2009.12.050","article-title":"Chilean experience in liver transplantation for acute liver failure in children","volume":"42","author":"Uribe M","year":"2010","journal-title":"Transplant Proc"},{"issue":"3","key":"ref25","first-page":"385","article-title":"Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina","volume":"11","author":"Sasb\u00f3n JS","year":"2010","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"ref26","first-page":"801","article-title":"Intravascular hypothermia for the management of intracranial hypertension in acute liver failure: case report","volume":"137","author":"Castillo L","year":"2009","journal-title":"Rev Med Chil"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1258\/td.2008.080369","article-title":"Severe adverse reactions to meglumine antimoniate in the treatment of visceral leishmaniasis: a report of 13 cases in the southwestern region of Brasil","volume":"39","author":"Oliveira AL","year":"2009","journal-title":"Trop Doct"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.transproceed.2009.02.007","article-title":"Living donor liver transplantation for acute liver failure: a single center experience","volume":"41","author":"Cari\u00fas LP","year":"2009","journal-title":"Transplant Proc"},{"issue":"3","key":"ref29","first-page":"134","article-title":"Intracranial pressure monitoring in children with fulminant hepatic failure","volume":"48","author":"Paiva WS","year":"2009","journal-title":"Rev Neurol"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1016\/j.transproceed.2008.03.128","article-title":"Living donor liver transplantation in pediatric patients with acute liver failure: safe and effective alternative","volume":"40","author":"Uribe M","year":"2008","journal-title":"Transplant Proc"},{"issue":"Suppl 2","key":"ref31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2893.2008.01033.x","article-title":"Hepatitis A acute liver failure: follow-up of paediatric patients in southern Brasil","volume":"15","author":"Ferreira CT","year":"2008","journal-title":"J Viral Hepat"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1478-3231.2007.01634.x","article-title":"Molecular characterization of hepatitis A virus in children with fulminant hepatic failure in Argentina","volume":"28","author":"Munn\u00e9 MS","year":"2008","journal-title":"Liver Int"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/adc.2006.115113","article-title":"Prognostic factors in paediatric acute liver failure","volume":"93","author":"Ciocca M","year":"2008","journal-title":"Arch Dis Child"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/INF.0b013e3180f60bed","article-title":"Hepatitis A as an etiologic agent of acute liver failure in Latin America","volume":"26","author":"Ciocca M","year":"2007","journal-title":"Pediatr Infect Dis J"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.trstmh.2006.10.007","article-title":"Fulminant hepatic failure in northern Brasil: morphological, immunohistochemical and pathogenic aspects of L\u00e1brea hepatitis and yellow fever","volume":"101","author":"Dias Jr LB","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"ref36","first-page":"125","article-title":"Molecular characterization of hepatitis E virus in three acute liver failure cases in children in Argentina","volume":"36","author":"Munn\u00e9 MS","year":"2006","journal-title":"Acta Gastroenterol Latinoam"},{"issue":"4","key":"ref37","first-page":"182","article-title":"Duration of viremia and fecal shedding of the virus in hepatitis A infected children","volume":"36","author":"Munn\u00e9 MS","year":"2006","journal-title":"Acta Gastroenterol Latinoam"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.transproceed.2005.09.097","article-title":"Living related liver transplantation. Why this option has been discarded in a pediatric liver transplant program in Chile","volume":"37","author":"Uribe M","year":"2005","journal-title":"Transplant Proc"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/j.transproceed.2005.09.096","article-title":"Pediatric liver transplantation: ten years of experience in a multicentric program in Chile","volume":"37","author":"Uribe M","year":"2005","journal-title":"Transplant Proc"},{"issue":"5","key":"ref40","first-page":"402","article-title":"Evolution of children one year post liver transplant","volume":"65","author":"Cuarterolo M","year":"2005","journal-title":"Medicina (B Aires)"},{"issue":"4","key":"ref41","first-page":"362","article-title":"Hepatotoxicity caused by antituberculosis drugs in pediatrics","volume":"25","author":"Reto Valiente LV","year":"2005","journal-title":"Rev Gastroenterol Peru"},{"issue":"2","key":"ref42","first-page":"113","article-title":"Liver dysfunction in recipients of hematopoietic stem cells. Impact on mortality","volume":"65","author":"Cocozzella D","year":"2005","journal-title":"Medicina (B Aires)"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.transproceed.2004.09.010","article-title":"ABO-incompatible liver transplantation: a new therapeutic option for patients with acute liver failure in Chile","volume":"37","author":"Uribe M","year":"2005","journal-title":"Transplant Proc"},{"issue":"2","key":"ref44","first-page":"180","article-title":"Acute liver failure complicating viral hepatitis A","volume":"8","author":"Diniz-Santos DR","year":"2004","journal-title":"Braz J Infect Dis"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/S0037-86822004000100019","article-title":"Fulminant hepatic failure in children and adolescents in Northern Brasil","volume":"37","author":"Fonseca JC","year":"2004","journal-title":"Rev Soc Bras Med Trop"},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.transproceed.2003.09.025","article-title":"Epidemiology and results of liver transplantation for acute liver failure in Chile","volume":"35","author":"Uribe M","year":"2003","journal-title":"Transplant Proc"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.transproceed.2003.09.024","article-title":"Outcomes of orthotopic liver transplantation in Chile","volume":"35","author":"Buckel E","year":"2003","journal-title":"Transplant Proc"},{"issue":"2","key":"ref48","first-page":"202","article-title":"Acetaminophen hepatotoxicity in an alcohol addicted student. Case report","volume":"127","author":"Fercovic A","year":"1999","journal-title":"Rev Med Chil"},{"issue":"1","key":"ref49","first-page":"11","article-title":"Wilson's disease (\u201chepatic form\u201d) in a region endemic for schistosomiasis mansoni: clinical presentation of 25 patients","volume":"35","author":"Galizzi-Filho J","year":"1998","journal-title":"Arq Gastroenterol"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcv.2014.06.016","article-title":"Fatal acute liver failure in a child due to acquired rubella infection","volume":"61","author":"Figueiredo CA","year":"2014","journal-title":"J Clin Virol"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1590\/S0103-05822014000100021","article-title":"Acute liver failure in a term neonate after repeated paracetamol administration","volume":"32","author":"Bucaretchi F","year":"2014","journal-title":"Rev Paul Pediatr"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/6082f3f8-2b92-42a2-8d6f-b9210d2f25bf","article-title":"Cellular senescence in livers from children with end stage liver disease","volume":"5","author":"Gutierrez-Reyes G","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1665-2681(19)31749-1","article-title":"Early treatment with N-acetylcysteine in children with acute liver failure secondary to hepatitis A","volume":"8","author":"Sotelo N","year":"2009","journal-title":"Ann Hepatol"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1665-2681(19)31799-5","article-title":"Acute liver failure due to white phosphorus ingestion","volume":"8","author":"Santos O","year":"2009","journal-title":"Ann Hepatol"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.gastrohep.2008.12.003","article-title":"Wilson's disease: pediatric experience in Costa Rica","volume":"32","author":"Jim\u00e9nez G","year":"2009","journal-title":"Gastroenterol Hepatol"},{"issue":"Suppl 2","key":"ref56","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-2893.2008.01023.x","article-title":"The need for an evidence-based decision-making process with regard to control of hepatitis A","volume":"15","author":"Gentile A","year":"2008","journal-title":"J Viral Hepat"},{"issue":"2","key":"ref57","first-page":"115","article-title":"Actualizaci\u00f3n de hepatitis autoinmune en pediatr\u00eda: reporte de un caso cl\u00ednico y revisi\u00f3n de la literatura","volume":"87","author":"Ospitaleche M","year":"2016","journal-title":"Arch Pediatr"},{"issue":"3","key":"ref58","first-page":"256","article-title":"Hemophagocytic lymphohistiocytosis presenting as acute liver failure in a patient with Hodgkin lymphoma: case report and review of the literature","volume":"35","author":"Bravo-Jaimes KM","year":"2015","journal-title":"Rev Gastroenterol Peru"},{"issue":"3","key":"ref59","first-page":"111","article-title":"Primer caso de falla hep\u00e1tica aguda por virus de la hepatitis E en Uruguay","volume":"36","author":"Mainardi V","year":"2014","journal-title":"Arch Med Interna"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4067\/S0370-41062013000300010","article-title":"Falla hep\u00e1tica fulminante por virus Epstein Barr: rol de los corticoides. Caso cl\u00ednico","volume":"84","author":"Viviani G","year":"2013","journal-title":"Rev Chil Pediatr"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4067\/S0370-41062009000200006","article-title":"Falla hep\u00e1tica fulminante en ni\u00f1os","volume":"80","author":"Roque JE","year":"2009","journal-title":"Rev Chil Pediatr"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1590\/S0004-28032008000300004","article-title":"Liver transplantation for acute liver failure: a 5 years experience","volume":"45","author":"Viana CF","year":"2008","journal-title":"Arq Gastroenterol"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4067\/S0370-41062005000400009","article-title":"Falla hep\u00e1tica fulminante por parvovirus B 19 y trasplante hep\u00e1tico, caso cl\u00ednico","volume":"76","author":"Roque JE","year":"2005","journal-title":"Rev Chil Pediatr"},{"issue":"1","key":"ref64","first-page":"65","article-title":"Falla hep\u00e1tica fulminante aguda: cuando el transplante hep\u00e1tico es la \u00fanica soluci\u00f3n","volume":"33","author":"Vidal CA","year":"2005","journal-title":"Rev Colomb Anestesiol"},{"issue":"1","key":"ref65","first-page":"8","article-title":"An experience of liver transplantation in Latin America: a medical center in Colombia","volume":"46","author":"Santos O","year":"2015","journal-title":"Colomb Med (Cali)"},{"issue":"7","key":"ref66","first-page":"918","article-title":"Small-for-size syndrome. Report of one case","volume":"137","author":"Yarur A","year":"2009","journal-title":"Rev Med Chil"},{"issue":"4","key":"ref67","first-page":"261","article-title":"Hepatotoxicidad detectada en un hospital de cuarto nivel en la ciudad de Medell\u00edn","volume":"33","author":"Restrepo JC","year":"2008","journal-title":"Acta Med Colomb"},{"issue":"6","key":"ref68","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1590\/S0036-46652004000600006","article-title":"Dapsone hypersensitivity syndrome in an adolescent during treatment during of leprosy","volume":"46","author":"Bucaretchi F","year":"2004","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"4","key":"ref69","first-page":"347","article-title":"Young infant with febrile syndrome, acute progressive encephalopathy and hepatic functional alteration","volume":"137","author":"Ridaura-Sanz C","year":"2001","journal-title":"Gac Med Mex"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00005176-199007000-00027","article-title":"Anti-liver-kidney microsome antibody-positive autoimmune hepatitis presenting as fulminant liver failure","volume":"11","author":"Porta G","year":"1990","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"7","key":"ref71","first-page":"753","article-title":"Fulminant hepatic failure in children","volume":"118","author":"Cordero J","year":"1990","journal-title":"Rev Med Chil"},{"issue":"2","key":"ref72","first-page":"113","article-title":"The Argentine experience with human immune deficiency virus positive patients in the waiting list for liver transplantation: preliminary analysis","volume":"43","author":"Villamil A","year":"2013","journal-title":"Acta Gastroenterol Latinoam"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1478-3231.2011.02654.x","article-title":"Activated lymphocytes and high liver expression of IFN-\u03b3 are associated with fulminant hepatic failure in patients","volume":"32","author":"Santos DC","year":"2012","journal-title":"Liver Int"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.transproceed.2010.12.003","article-title":"Results of retransplantation for primary nonfunction in a single center","volume":"43","author":"Coelho MP","year":"2011","journal-title":"Transplant Proc"},{"issue":"5","key":"ref75","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.transproceed.2010.01.077","article-title":"Multiple clinical presentations of lymphoproliferative disorders in pediatric liver transplant recipients: a single-center experience","volume":"42","author":"Pinho-Apezzato ML","year":"2010","journal-title":"Transplant Proc"},{"issue":"3","key":"ref76","first-page":"218","article-title":"Liver transplantation for neurologic Wilson's disease: reflections on two cases within a Mexican cohort","volume":"74","author":"Duarte-Rojo A","year":"2009","journal-title":"Rev Gastroenterol Mex"},{"issue":"7","key":"ref77","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/lt.24435","article-title":"Pediatric acute liver failure in Brasil: is living donor liver transplantation the best choice for treatment?","volume":"22","author":"Tannuri AC","year":"2016","journal-title":"Liver Transpl"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1093\/jpids\/piu068","article-title":"Single-dose universal hepatitis A immunization in Argentina: low viral circulation and high persistence of protective antibodies up to 4 years","volume":"4","author":"Vizzotti C","year":"2015","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"1","key":"ref79","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/INF.0000000000000042","article-title":"Impact of the single-dose immunization strategy against hepatitis A in Argentina","volume":"33","author":"Vizzotti C","year":"2014","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/hep.20006","article-title":"Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination","volume":"39","author":"Chen HL","year":"2004","journal-title":"Hepatology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/HMER.S22309","article-title":"Decline in HAV-associated fulminant hepatic failure and liver transplant in children in Argentina after the introduction of a universal hepatitis A vaccination program","volume":"3","author":"Cervio G","year":"2011","journal-title":"Hepat Med"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.20293","article-title":"Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure","volume":"40","author":"Lee WM","year":"2004","journal-title":"Hepatology"},{"issue":"2","key":"ref83","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-2008-1073115","article-title":"Acute liver failure in children","volume":"28","author":"Squires Jr RH","year":"2008","journal-title":"Semin Liver Dis"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v65n6\/1806-9282-ramb-65-06-0914.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T08:56:36Z","timestamp":1664009796000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302019000600914&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":83,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["S0104-42302019000600914"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.65.6.914","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}