{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:59:37Z","timestamp":1785556777799,"version":"3.56.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  Acute pancreatitis (AP) is an important clinical event with an increased frequency due to increased life expectancy, obesity, and alcohol use. There are some data about the elevation of carbohydrate antigen (CA) 19-9 levels in benign and malignant pancreaticobiliary events in the literature, but in AP they are limited. The aim of this study was to evaluate the CA 19-9 level in patients with AP and determine its relationship according to the cause.  METHODS  Between 2010-2018, 173 patients evaluated with CA 19-9 levels as well as by standard laboratory tests were included in the study. CA 1 9-9 levels and laboratory findings were compared in patients with pancreatitis due to gallstone (group 1) and metabolic\/toxic reasons such as hyperlipidemia, alcohol, or drug use (group 2).  RESULTS  There were 114 (66%) patients in the group 1 and 59 (34%) patients in the group 2. The majority of patients with high CA 19-9 level were in group 1 (92.1% vs 6.8%). CA 19-9 level, as well as amylase, lipase, AST, ALT and bilirubin levels were found to be statistically higher in patients with AP due to gallstone compared to patients with metabolic\/toxic AP.  CONCLUSIONS  Patients with AP due to gallstone, were found to have a high level of CA 19-9 at admission. Early stage CA 19-9 levels may contribute to standard laboratory tests in the etiology of the disease in patients diagnosed with AP.<\/jats:p>","DOI":"10.1590\/1806-9282.65.7.965","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T15:35:37Z","timestamp":1564846537000},"page":"965-970","source":"Crossref","is-referenced-by-count":8,"title":["CA 19-9 levels in patients with acute pancreatitis due to gallstone and metabolic\/toxic reasons"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-1982","authenticated-orcid":false,"given":"Omer Burcak","family":"Binicier","sequence":"first","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-6178","authenticated-orcid":false,"given":"Zehra Betul","family":"Pakoz","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,7]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pan.2017.01.005","article-title":"The incidence and aetiology of acute pancreatitis across Europe","volume":"17","author":"Roberts SE","year":"2017","journal-title":"Pancreatology"},{"issue":"6","key":"ref2","first-page":"620","article-title":"CA19-9 antigen levels can distinguish between benign and malignant pancreaticobiliary disease","volume":"8","author":"Morris-Stiff G","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"3","key":"ref3","first-page":"PC06","article-title":"The role of CA19-9 in predicting tumour resectability in carcinoma head of pancreas","volume":"10","author":"Pandiaraja J","year":"2016","journal-title":"J Clin Diagn Res"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejso.2006.10.004","article-title":"Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer","volume":"33","author":"Goonetilleke KS","year":"2007","journal-title":"Eur J Surg Oncol"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"12745","DOI":"10.18632\/oncotarget.23993","article-title":"Significant increased CA199 levels in acute pancreatitis patients predicts the presence of pancreatic cancer","volume":"9","author":"Teng D","year":"2018","journal-title":"Oncotarget"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1007\/s00268-018-4605-y","article-title":"Surgical indication for advanced intrahepatic cholangiocarcinoma according to the optimal preoperative carbohydrate antigen 19-9 cutoff value","volume":"42","author":"Yamamoto Y","year":"2018","journal-title":"World J Surg"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/MPA.0000000000001181","article-title":"The levels of tumor markers in pancreatic neuroendocrine carcinoma and their values in differentiation between pancreatic neuroendocrine carcinoma and pancreatic ductal adenocarcinoma","volume":"47","author":"Zhuge X","year":"2018","journal-title":"Pancreas"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1007\/s10620-008-0289-8","article-title":"Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration","volume":"53","author":"Ong SL","year":"2008","journal-title":"Dig Dis Sci"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1007\/s10620-006-9164-7","article-title":"Extremely elevated CA19-9 in acute cholangitis","volume":"52","author":"Sheen-Chen SM","year":"2007","journal-title":"Dig Dis Sci"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/531640","article-title":"Carbohydrate 19.9 antigen serum levels in liver disease","volume":"2013","author":"Bertino G","year":"2013","journal-title":"Biomed Res Int"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0953-6205(02)00002-X","article-title":"High CA 19-9 levels in benign biliary tract diseases. 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