{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:58:13Z","timestamp":1740142693908,"version":"3.37.3"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  The objective of this study was to investigate the effects of low triiodothyronine syndrome (LT3S) on platelet function and clotting factors in patients with nephrotic syndrome(NS).  METHODS  Patients with primary nephrotic syndrome were divided into two groups, normal thyroid function (group A) and LT3S (group B), based on whether they had LT3S or not. Healthy subjects were selected as the control group (group C). Blood coagulation function was detected in each group. The platelet activation function (CD62P, CD63) was determined by flow cytometry. The platelet aggregation rate was detected by an optical method using adenosine diphosphate and arachidonic acid as inducers.  RESULTS  The proportion of primary nephrotic syndrome with LT3S was 23.2% (69\/298). Compared with group C, group A had higher CD62P and PAgTADP, and group B had higher CD62P, CD63, PAgTAA, and PAgTADP; the difference was statistically significant (all P &lt; 0.05). There was no significant difference in renal pathology between group A and group B (X2 = 4.957, P = 0.421). Compared with group A, the 24-hour urine protein, CD63, PAgTAA, and PAgTADP were higher in group B, and APTT and Alb were lower. The difference was statistically significant (P &lt; 0.05). Logistic regression analysis showed that LT3S was associated with CD36 (OR: 3.516; 95% CI: 1.742~8.186; P = 0.004) and PAgTAA (OR: 0.442; 95% CI: 1.001~1.251; P = 0.037).  CONCLUSION  NS patients are prone to LT3S. Patients with LT3S may have abnormal platelet activation and increase of platelet aggregation.<\/jats:p>","DOI":"10.1590\/1806-9282.65.7.988","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T15:35:30Z","timestamp":1564846530000},"page":"988-992","source":"Crossref","is-referenced-by-count":4,"title":["Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-3122","authenticated-orcid":false,"given":"Jianhua","family":"Wu","sequence":"first","affiliation":[{"name":"Nanjing Medical University,  China; Nantong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-2067","authenticated-orcid":false,"given":"Naifeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Nantong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-6096","authenticated-orcid":false,"given":"Xiaolan","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-1282","authenticated-orcid":false,"given":"ChangYing","family":"Xing","sequence":"additional","affiliation":[{"name":"Nanjing Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,7]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1055\/s-0033-1343887","article-title":"Thrombosis in Nephrotic Syndrome","volume":"39","author":"Barbano B","year":"2013","journal-title":"Semin Thromb 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Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis[J]","volume":"169","author":"Lamba N","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1111\/jth.12728","article-title":"Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid","volume":"12","author":"Undas A","year":"2015","journal-title":"J Thromb Haemos"},{"issue":"1","key":"ref18","first-page":"93","article-title":"Thyroid gland and pulmonary hypertension. What\u2019s the link","volume":"55","author":"Marvisi M","year":"2013","journal-title":"Panminerva Med"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v65n7\/1806-9282-ramb-65-7-0988.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T15:59:13Z","timestamp":1581091153000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302019000700988&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["S0104-42302019000700988"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.65.7.988","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}