{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:58:15Z","timestamp":1740142695464,"version":"3.37.3"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  INTRODUCTION The possibility that hypothermia has a therapeutic role during or after resuscitation from severe perinatal asphyxia has been a longstanding focus of research. Studies designed around this fact have shown that moderate cerebral hypothermia, initiated as early as possible, has been associated with potent, long-lasting neuroprotection in perinatal patients.  OBJECTIVES To review the benefits of hypothermia in improving cellular function, based on the cellular characteristics of hypoxic-ischemic cerebral injury and compare the results of two different methods of cooling the brain parenchyma.  METHODS Medline, Lilacs, Scielo, and PubMed were searched for articles registered between 1990 and 2019 in Portuguese and English, focused on trials comparing the safety and effectiveness of total body cooling with selective head cooling with HIE.  RESULTS We found that full-body cooling provides homogenous cooling to all brain structures, including the peripheral and central regions of the brain. Selective head cooling provides a more extensive cooling to the cortical region of the brain than to the central structures.  CONCLUSIONS Both methods demonstrated to have neuroprotective properties, although full-body cooling provides a broader area of protection. Recently, head cooling combined with some body cooling has been applied, which is the most promising approach. The challenge for the future is to find ways of improving the effectiveness of the treatment.<\/jats:p>","DOI":"10.1590\/1806-9282.65.8.1116","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T19:27:48Z","timestamp":1568230068000},"page":"1116-1121","source":"Crossref","is-referenced-by-count":4,"title":["Selective head cooling and whole body cooling as neuroprotective agents in severe perinatal asphyxia"],"prefix":"10.1590","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5069-9871","authenticated-orcid":false,"given":"Mahara","family":"Nonato","sequence":"first","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-2286","authenticated-orcid":false,"given":"Larissa","family":"Gheler","sequence":"additional","affiliation":[{"name":"Unifai,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-3440","authenticated-orcid":false,"given":"Jo\u00e3o Vitor","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Universidade dos Grandes Lagos,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-6857","authenticated-orcid":false,"given":"Marise","family":"Audi","sequence":"additional","affiliation":[{"name":"Hospital Benefic\u00eancia Portuguesa,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-3794","authenticated-orcid":false,"given":"Mirto","family":"Prandini","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,8]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0095-5108(18)30395-6","article-title":"Pathophysiology of perinatal asphyxia","volume":"20","author":"Williams CE","year":"1993","journal-title":"Clin Perinatol"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/jpme.1994.22.2.129","article-title":"Diagnosis of severe birth asphyxia and early prediction of neonatal neurological outcome in term asphyxiated newborns","volume":"22","author":"Wayenberg JL","year":"1994","journal-title":"J. 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