{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:11:00Z","timestamp":1767651060272,"version":"3.37.3"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  Describe the clinical and demographic characteristics of pediatric patients with non-Hodgkin\u2019s lymphoma (NHL) enrolled in a tertiary unit of Pediatric Hematology between 1982-2015.  PATIENTS AND METHODS  A retrospective cohort study of 140 patients aged 16 years or less with NHL. Demographic characteristics, data on diagnosis, and outcomes were analyzed. The overall survival (OS) analysis and stratification by the most frequent histological subtypes were performed using the Kaplan-Meier method.  RESULTS  One hundred and thirty-six patients with de novo NHL and four with NHL as a second malignancy were analyzed. The median age at diagnosis was 6.4 years (interquartile range, 4.2 to 11.1 years); 101 patients were males. Four patients had primary immunodeficiency, four had human immunodeficiency virus, two post-liver transplantation, and one had autoimmune lymphoproliferative syndrome. The most frequent histological type was NHL of mature B- cell (B-NHL-B; 67.1%), with Burkitt\u2019s lymphoma being the most frequent subtype, and lymphoblastic lymphoma (LBL, 21.4%). The main clinical manifestation at the diagnosis was abdominal tumors (41.4%). During the follow-up time, 13 patients relapsed, but five of them reached a second remission. Thirty-five patients died, and 103 remained alive in clinical remission. No contact was possible for two patients. The OS at 5 years was 74.5% (\u00b1 3.8%). The OS estimated for patients with LBL, NHL-B, and the remaining was 80.4%\u00b17.9%, 72.8%\u00b14.7%, and 74.5%\u00b111%, respectively (P = 0.58).  CONCLUSION  Our results are comparable with cohorts from other middle-income countries.<\/jats:p>","DOI":"10.1590\/1806-9282.66.1.25","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T15:29:38Z","timestamp":1582644578000},"page":"25-30","source":"Crossref","is-referenced-by-count":5,"title":["30 Years of Experience with Non-Hodgkin Lymphoma in Children and Adolescents: a retrospective cohort study"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-6769","authenticated-orcid":false,"given":"Maria Christina L.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-4645","authenticated-orcid":false,"given":"Keyla C.","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-938X","authenticated-orcid":false,"given":"Andrea C.","family":"Brito","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3377-0613","authenticated-orcid":false,"given":"Marcia K.","family":"Campos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0249-963X","authenticated-orcid":false,"given":"Mitiko","family":"Murao","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-2972","authenticated-orcid":false,"given":"Rebeca","family":"Gusm\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-1948","authenticated-orcid":false,"given":"Ana Ang\u00e9lica L.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9665-2115","authenticated-orcid":false,"given":"Marcos B.","family":"Viana","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,1]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1016\/j.canep.2012.03.006","article-title":"Lymphoma subtype incidence rates in children and adolescents: first report from Brasil","volume":"36","author":"Ferreira JM","year":"2012","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5581\/1516-8484.20120093","article-title":"Clinical course and prognostic factors of children with Burkitt\u2019s lymphoma in a developing country: the experience of a single centre in Brasil","volume":"34","author":"Cunha KC","year":"2012","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/1806-9282.62.01.59","article-title":"Outcome of children and adolescents with lymphoblastic 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How to treat children and adolescents with relapsed non-Hodgkin lymphoma?","volume":"31","author":"Woessmann W","year":"2013","journal-title":"Hematol Oncol"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v66n1\/1806-9282-ramb-66-1-0025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T13:34:50Z","timestamp":1611408890000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302020000100025&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["S0104-42302020000100025"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.66.1.25","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}