{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T05:52:29Z","timestamp":1743832349078,"version":"3.37.3"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  Acne vulgaris in female adolescents, when severe or accompanied by other signs of androgenization, may represent a sign of hyperandrogenemia often underdiagnosed, which will have harmful consequences for adult life. The objective of this cross-sectional and retrospective study was to demonstrate the incidence of hormonal changes in the cases of female adolescents with severe or extensive acne, with or without other signs of hyperandrogenism, and propose a hormonal research pattern which should be indicated in order to detect early hyperandrogenemia.  METHODS  The medical records of 38 female patients aged between 9 and 15 years old with grade II and\/or III acne were analyzed. The dehydroepiandrosterone sulfate, dehydroepiandrostenedione, and androstenedione, total testosterone, and dihydrotestosterone sulfate hormones were required prior to initiation of treatment. The hormonal dosages were performed in the serum after at least 3 hours of fasting by means of radioimmunoassay tests.  RESULTS  Of the 38 patients included, 44.7% presented changes in androgen levels (hyperandrogenemia), and the two most frequently altered hormones were DHEA and androstenedione, with the same incidence (23.6%).  CONCLUSIONS  The correct and early diagnosis provides an effective and agile approach, including antiandrogen therapy, with the purpose of avoiding the reproductive and metabolic repercussions, besides controlling the inflammatory picture and avoid aesthetic complications.<\/jats:p>","DOI":"10.1590\/1806-9282.66.1.36","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T15:29:27Z","timestamp":1582644567000},"page":"36-41","source":"Crossref","is-referenced-by-count":1,"title":["Dosages of androgenic hormones in adolescent patients with severe acne"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-1318","authenticated-orcid":false,"given":"Marisa Gonzaga da","family":"Cunha","sequence":"first","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-3806","authenticated-orcid":false,"given":"Caio","family":"Moraes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana","family":"Cebrian","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-2028","authenticated-orcid":false,"given":"Rafaela Ferreira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f4nia Isabel Friedlaender","family":"Reple","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-1563","authenticated-orcid":false,"given":"Carlos D\u2019Apparecida","family":"Machado Filho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-1589","authenticated-orcid":false,"given":"Fernando Luiz Affonso","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas,  Brasil; Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,1]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2007-961807","article-title":"Sexual hormones in human skin","volume":"39","author":"Zouboulis CC","year":"2007","journal-title":"Horm Metab 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