{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:31:28Z","timestamp":1789594288577,"version":"build-2803163510"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  To evaluate the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with HIV\/AIDS.  METHODS  The systematic review included articles indexed in MEDLINE (by PubMed), Web of Science, IBECS, and LILACS. Studies eligible included the year of publication, diagnose criteria of NAFLD and HIV, and were published in English, Portuguese, or Spanish from 2006 to 2018. The exclusion criteria were studies with HIV-infection patients and other liver diseases. Two reviewers were involved in the study and applied the same methodology, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).  RESULTS  One hundred and sixteen papers were selected, including full articles, editorial letters, and reviews. Twenty-seven articles were excluded because they did meet the inclusion criteria. A total of 89 articles were read, and 13 were considered eligible for this review. Four case series used imaging methods to identify NAFLD, and nine included histology. The prevalence of NAFLD in HIV-patients ranged from 30%-100% and, in nonalcoholic steatohepatitis (NASH), from 20% to 89%. A positive association between dyslipidemia, insulin resistance, and body mass index was observed. There was no agreement between the studies that evaluated the relationship between antiretroviral drugs and NAFLD.  CONCLUSION  This systematic review showed a high prevalence of NAFLD in HIV-patients, which was associated with metabolic risk factors. The possible association between antiretroviral therapy and NAFLD needs further studies.<\/jats:p>","DOI":"10.1590\/1806-9282.66.1.81","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T15:30:05Z","timestamp":1582644605000},"page":"81-86","source":"Crossref","is-referenced-by-count":7,"title":["Non-alcoholic fatty liver disease in patients infected with human immunodeficiency virus: a systematic review"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-8222","authenticated-orcid":false,"given":"Leonardo Bispo","family":"Pires","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-2080","authenticated-orcid":false,"given":"Raquel","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-1199","authenticated-orcid":false,"given":"Daniel","family":"Vargas","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-688X","authenticated-orcid":false,"given":"Carla","family":"Daltro","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-6919","authenticated-orcid":false,"given":"Helma P","family":"Cotrim","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,1]]},"reference":[{"key":"ref1","series-title":"Get on the fast-track: the life-cycle approach to HIV, 2016"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/apt.13052","article-title":"Clinical, biochemical and histological differences between HIV- associated NAFLD and primary NAFLD: a case-control study","volume":"41","author":"Vodkin I","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2007.02.009","article-title":"Epidemiology and natural history of NAFLD and NASH","volume":"11","author":"Ong JP","year":"2007","journal-title":"Clin Liver Dis"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/flgastro-2013-100403","article-title":"Non-alcoholic fatty liver disease: a practical approach 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