{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:49:10Z","timestamp":1792190950825,"version":"4.4.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The relationship between the clinicopathological and sociodemographics characteristics of acral melanomas diagnosed at BACKGROUND: This study aimed to investigate the frequency of VEGF gene insertion (I) \/ deletion (D) polymorphism (rs35569394) in patients with Polycystic Ovarian Syndrome (PCOS) and to compare with a control population to verify its association with the pathology.  METHODS: 206 women participated in this study, 103 with PCOS (group of patients) and 103 without the disease (control group). After extraction of genomic DNA from the samples, molecular analysis was performed by Polymerase Chain Reaction (PCR) and electrophoresis in polycrylamide. Descriptive analysis, univariate analysis and logistic regression model were used. Results were presented in odds ratio (OR) and 95% confidence interval (95% CI), considering the significance of p &lt;0.05.  RESULTS: There were no statistical differences between patients and controls for allele frequencies (\u03c72 = 1.16, p = 0.56). The genotypic frequency distribution was in Hardy Weinberg equilibrium for the patients (\u03c72 = 2.42; p &lt;0.05), but not for the control group (\u03c72 = 7.26; p &lt;0.05). Regarding risk factors for the syndrome, a history of familial PCOS is more frequent among women with the syndrome.  CONCLUSIONS: In the present study, there is no association between VEGF gene I \/ D polymorphism and PCOS.<\/jats:p>","DOI":"10.1590\/1806-9282.66.10.1396","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T19:27:20Z","timestamp":1604690840000},"page":"1396-1401","source":"Crossref","is-referenced-by-count":4,"title":["VEGF gene rs35569394 polymorphism in patients with Polycystic Ovary Syndrome"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5870-6987","authenticated-orcid":false,"given":"Sheila Silveira","family":"Fernandes","sequence":"first","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-5174","authenticated-orcid":false,"given":"Alessandra Bernadete Trov\u00f3 de","family":"Marqui","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-3609","authenticated-orcid":false,"given":"Daniela Reis Fernandes","family":"Teles","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-1103","authenticated-orcid":false,"given":"Elisabete Aparecida Montovani Rodrigues","family":"Resende","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-6620","authenticated-orcid":false,"given":"Marco F\u00e1bio Prata","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-5242","authenticated-orcid":false,"given":"Mariana Kefalas Oliveira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-805X","authenticated-orcid":false,"given":"Mariangela Torreglosa Ruiz","family":"Cintra","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,10]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1530\/REP-17-0597","article-title":"Ovarian angiogenesis in polycystic ovary syndrome","volume":"155","author":"Di Pietro M","year":"2018","journal-title":"Reproduction"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz R","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4274\/jtgga.galenos.2019.2018.0142","article-title":"Polycystic ovarian syndrome: environmental\/occupational, lifestyle factors - 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