{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:03:54Z","timestamp":1787241834707,"version":"build-2736575974"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY This study aimed to evaluate the efficacy of the action of the Lactobacillus Plantarum probiotic as a immunomodulatory and hypolipidemic agent in dyslipidemic nephrotic children and adolescents.  METHODS: This is a randomized, double-blind, placebo-controlled clinical trial in pediatric, compensated or partially compensated nephrotic syndrome and dyslipidemic subjects undergoing regular outpatient follow-up. Serum lipid and TNF-\u03b1 (proinflammatory) and IL-10 (anti-inflammatory) cytokine variations were evaluated. Cytokines were analyzed by enzyme-linked immunosorbent assay (ELISA).  RESULTS: In the probiotic group there was a tendency to reduce TNF-\u03b1 levels and increase IL-10 levels when compared to controls. Regarding the lipid profile, there was a decrease in serum triglyceride (6.0 mg \/ dL) and total cholesterol (41.5 mg \/ dL) levels in the probiotic group when compared to baseline levels, while in the control group there was an increase in serum triglyceride (49.5 mg \/ dL) and total cholesterol (8.0 mg \/ dL) levels, respectively.  CONCLUSION: Preliminary results suggest that L. Plantarum showed an immunomodulatory and hypolipidemic effect in nephrotic and dyslipidemic pediatric subjects.<\/jats:p>","DOI":"10.1590\/1806-9282.66.11.1487","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T17:37:45Z","timestamp":1606930665000},"page":"1487-1492","source":"Crossref","is-referenced-by-count":8,"title":["Inflammatory cytokines and lipid profile in children and adolescents with nephrotic syndrome receiving L. Plantarum: a randomized, controlled feasibility trial"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9578-210X","authenticated-orcid":false,"given":"Patr\u00edcia Marques","family":"Fortes","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4822-1526","authenticated-orcid":false,"given":"Ricardo Vieira","family":"Teles Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-492X","authenticated-orcid":false,"given":"Lucas Henrique Souza de","family":"Azev\u00eado","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-2653","authenticated-orcid":false,"given":"Vict\u00f3ria Coelho J\u00e1come","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-9139","authenticated-orcid":false,"given":"Paulo S\u00e9rgio Sucasas da","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"ref1","series-title":"Princ\u00edpios de nefrologia e dist\u00farbios hidroeletrol\u00edticos","first-page":"402","volume-title":"Glomerulonefrites prim\u00e1rias","author":"Carvalho M","year":"2003","edition":"4a ed."},{"key":"ref2","series-title":"Pediatric 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