{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:34:56Z","timestamp":1770741296550,"version":"3.49.0"},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  INTRODUCTION  A covid-19 pandemic decreed by WHO has raised greater awareness of it.  EPIDEMIOLOGY  The infection reached the mark of 350,000 patients in 33 countries and affected as comorbidities the presence of comorbidities and advanced age.  TRANSMISSIBILITY  The transmissibility calculated so far is similar to the H1N1 epidemic, but with lower mortality rates.  PHYSIOPATHOLOGY  The SARS-CoV-2 virus, of the Coronaviridae family, has the capacity for cellular invasion through the angiotensin-converting enzyme 2 does not have a lower respiratory epithelium and in the cells of the small intestine mucosa.  CLINICAL MANIFESTATIONS  a presentation can be divided into mild (fever, fatigue, cough, myalgia, and sputum) and severe (cyanosis, dyspnoea, tachypnea, chest pain, hypoxemia and need for clinical measurement) and has an estimated estimate of 2%.  DIAGNOSIS  allows the detection of viral load in CRP-TR of patients with high clinical suspicion.  TREATMENT  based on supportive measures and infection control. In severe cases, the use of medications such as hydroxychloroquine and azithromycin or medication can be promising. Take care to avoid the use of corticosteroids. There are no restrictions on the use of resources and ACEIs \/ ARBs.<\/jats:p>","DOI":"10.1590\/1806-9282.66.2.116","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T23:13:53Z","timestamp":1589930033000},"page":"116-123","source":"Crossref","is-referenced-by-count":12,"title":["Coronavirus: a clinical update of Covid-19"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-5917","authenticated-orcid":false,"given":"Mateus da Silveira","family":"Cespedes","sequence":"first","affiliation":[{"name":"Universidade Estadual de Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-4286","authenticated-orcid":false,"given":"Jos\u00e9 Carlos Rosa Pires de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,2]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.micinf.2020.01.004","article-title":"Pathogenicity and transmissibility of 2019-nCoV - A quick overview and comparison with other emerging viruses","volume":"22","author":"Chen J","year":"2020","journal-title":"Microbes and Infection"},{"key":"ref2","series-title":"Preven\u00e7\u00e3o e controle de infec\u00e7\u00e3o durante os cuidados de sa\u00fade quando houver suspeita de nova infec\u00e7\u00e3o por coronav\u00edrus (nCoV)","year":"2020"},{"issue":"20","key":"ref3","first-page":"30079","article-title":"Curso cl\u00ednico e resultados de pacientes cr\u00edticos com pneumonia por SARS-CoV-2 em Wuhan, China","author":"Yang X","year":"2020","journal-title":"Lancet Respir Med"},{"key":"ref4","article-title":"Caracter\u00edsticas cl\u00ednicas de 138 pacientes hospitalizados com 2019 nova pneumonia infectada por coronav\u00edrus em Wuhan, China","author":"Wang D","journal-title":"JAMA"},{"key":"ref5","article-title":"Monitoramento ativo de pessoas expostas a pacientes com COVID-19 confirmado - Estados Unidos, janeiro-fevereiro de 2020","volume":"69","author":"Burke RM","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref6","article-title":"Detec\u00e7\u00e3o de novo coronav\u00edrus por RT-PCR em amostras de fezes de Crian\u00e7a Assintom\u00e1tica, China","volume":"26","author":"Tang A","year":"2020","journal-title":"Emerg Infect Dis"},{"issue":"20","key":"ref7","first-page":"30040","article-title":"Estado portador assintom\u00e1tico, doen\u00e7a respirat\u00f3ria aguda e pneumonia devido a coronav\u00edrus 2 da s\u00edndrome respirat\u00f3ria aguda grave (SARS-CoV-2): fatos e mitos","author":"Lai CC","year":"2020","journal-title":"J Microbiol Immunol Infect"},{"key":"ref8","article-title":"Atividade antiviral in vitro e proje\u00e7\u00e3o de projeto de dosagem otimizada de hidroxicloroquina para o tratamento do coronav\u00edrus 2 da s\u00edndrome respirat\u00f3ria aguda grave (SARS-CoV-2)","author":"Yao X","year":"2020","journal-title":"Clin Infect Dis"},{"key":"ref9","article-title":"COVID-19: uma recomenda\u00e7\u00e3o para examinar o efeito da hidroxicloroquina na preven\u00e7\u00e3o de infec\u00e7\u00e3o e progress\u00e3o","author":"Dan Z","year":"2020","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"ref10","series-title":"Protocolo de Manejo Cl\u00ednico para o Novo Coronav\u00edrus (2019-nCoV)","year":"2020"},{"key":"ref11","series-title":"Cecil Medicina Interna","author":"Goldman L","year":"2012","edition":"24"},{"key":"ref12","series-title":"Tratado de Pediatria","author":"Behrman Richard E.","year":"2013","edition":"19a"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v66n2\/1806-9282-ramb-66-2-0116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T18:54:40Z","timestamp":1611428080000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302020000200116&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["S0104-42302020000200116"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.66.2.116","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}