{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:59:27Z","timestamp":1778885967471,"version":"3.51.4"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  INTRODUCTION  A covid-19 pandemic decreed by WHO has raised greater awareness of it.  EPIDEMIOLOGY  The infection, reached the mark of 2,000,000 patients in 33 countries and caused the risk of the presence of comorbidities and advanced age.  TRANSMISSIBILITY  The transmissibility calculated so far is similar to the H1N1 epidemic, but with lower mortality rates.  PHYSIOPATHOLOGY  The SARS-CoV-2 virus, of the Coronaviridae family, has the capacity for cellular invasion through the angiotensin-converting enzyme 2 does not have a lower respiratory epithelium and in the cells of the small intestine mucosa.  CLINICAL MANIFESTATIONS  a presentation can be divided into mild (fever, fatigue, cough, myalgia, and sputum) and severe (cyanosis, dyspnoea, tachypnea, chest pain, hypoxemia and need for clinical measurement) and has an estimated estimate of 2%.  DIAGNOSIS  allows the detection of viral load in CRP-TR of patients with high clinical suspicion.  TREATMENT  based on supportive measures and infection control. In severe cases, the use of medications such as hydroxychloroquine and azithromycin or medication can be promising. Take care to avoid the use of corticosteroids. There are no restrictions on the use of resources and IECAs \/ BRAs.<\/jats:p>","DOI":"10.1590\/1806-9282.66.4.547","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T12:49:54Z","timestamp":1592225394000},"page":"547-557","source":"Crossref","is-referenced-by-count":18,"title":["Sars-CoV-2: A clinical update - II"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-5917","authenticated-orcid":false,"given":"Mateus da Silveira","family":"Cespedes","sequence":"first","affiliation":[{"name":"Universidade Estadual do Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-3770","authenticated-orcid":false,"given":"Jos\u00e9 Carlos Rosa Pires de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,4]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.micinf.2020.01.004","article-title":"Pathogenicity and transmissibility of 2019-nCoV: a quick overview and comparison with other emerging viruses","volume":"22","author":"Chen J","year":"2020","journal-title":"Microbes Infect"},{"key":"ref2","series-title":"Protocolo de manejo cl\u00ednico para o novo coronav\u00edrus (2019-nCoV)","year":"2020"},{"key":"ref3","series-title":"Morgan Stanley to Buy E-Trade, Linking Wall Street and Main Street"},{"key":"ref4","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","author":"Wang D","year":"2020","journal-title":"JAMA"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","DOI":"10.3201\/eid2606.200301","article-title":"Detection of novel coronavirus by RT-PCR in stool samples from an asymptomatic child, China","volume":"26","author":"Tang A","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"ref6","article-title":"COVID-19 and the digestive system","author":"Wong SH","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"ref7","article-title":"Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn","author":"Dong L","year":"2020","journal-title":"JAMA"},{"key":"ref8","series-title":"High temperature and high humidity reduce the transmission of COVID-19","author":"Wang J","year":"2020"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMsr2005760","article-title":"Renin-angiotensin-aldosterone system inhibitors in patients with COVID-19","author":"Vaduganathan M","year":"2020","journal-title":"N Engl J Med"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1681\/ASN.2006050423","article-title":"Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes","volume":"17","author":"Ye M","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref11","article-title":"COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression","author":"Zhou D","year":"2020","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrd.2015.37","article-title":"Coronaviruses: drug discovery and therapeutic options","volume":"15","author":"Zumla A","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"ref13","first-page":"1","article-title":"Should COVID-19 concern nephrologists? 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