{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:57:20Z","timestamp":1740142640733,"version":"3.37.3"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  INTRODUCTION  Celiac disease (CeD) is an autoimmune disease that can be delayed in diagnosis due to the presence of atypical and asymptomatic cases in adulthood. Herein we aimed to study the frequency of CeD and evaluate whether magnified endoscopy and magnified\/FICE (flexible spectral imaging color enhancement) techniques contribute to the diagnosis in patients with serum iron and vitamin B12 deficiency.  METHODS  We evaluated 50 adult patients (10 males and 40 females) who had serum iron and vitamin B12 deficiency, prospectively. All the patients had undergone upper gastrointestinal system endoscopy by the same endoscopist. The second part of the duodenum was evaluated with white light, magnified, and magnified\/FICE endoscopy. Biopsy specimens were evaluated by the same pathologist. The specimens diagnosed as CeD were classified according to the Modified Marsh-Oberhuber criteria.  RESULTS  10 of 50 patients (20%) were diagnosed as CeD. The average age was 41\u00b111 years (20-67 years). Thirty percent of CeD diagnosed patients had typical CeD symptoms. Six of 10 patients (60%) who were diagnosed as CeD had typical endoscopic images under white lighted endoscopy. All of these 10 patients (100%) showed villous irregularity, partial villous atrophy, or total villous atrophy consistent with CeD with magnified and magnified\/FICE endoscopy.  CONCLUSION  The practical use of magnified\/FICE endoscopy allows us to differentiate mucosal abnormalities of the duodenum and minimize false-negative results that indicate normal mucosal findings with conventional endoscopy.<\/jats:p>","DOI":"10.1590\/1806-9282.66.6.818","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T12:14:24Z","timestamp":1595247264000},"page":"818-823","source":"Crossref","is-referenced-by-count":4,"title":["Serum iron and vitamin B 12 deficiency could indicate celiac disease by flexible spectral imaging color enhancement"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-6739","authenticated-orcid":false,"given":"Seval","family":"Akay","sequence":"first","affiliation":[{"name":"Kutahya Health Sciences University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-1982","authenticated-orcid":false,"given":"Omer Burcak","family":"Binicier","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-3491","authenticated-orcid":false,"given":"Ebru","family":"Cakir","sequence":"additional","affiliation":[{"name":"Katip Celebi University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0936-8691","authenticated-orcid":false,"given":"Harun","family":"Akar","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,6]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0950-3528(95)90032-2","article-title":"Morphology of the mucosal lesion in gluten sensitivity","volume":"9","author":"Marsh MN","year":"1995","journal-title":"Bailleres Clin Gastroenterol"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0753-3322(01)80003-2","article-title":"Histopathology of celiac disease","volume":"54","author":"Oberhuber G","year":"2000","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1155\/2001\/367832","article-title":"The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment","volume":"15","author":"Stolte M","year":"2001","journal-title":"Can J Gastroenterol"},{"issue":"10115","key":"ref4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","article-title":"Coeliac disease","volume":"391","author":"Lebwohl B","year":"2018","journal-title":"Lancet"},{"issue":"25","key":"ref5","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMcp1113994","article-title":"Clinical practice. Celiac disease","volume":"367","author":"Fasano A","year":"2012","journal-title":"N Engl J Med"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MPG.0000000000000887","article-title":"Presenting pattern of pediatric celiac disease","volume":"62","author":"Khatib M","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/MCG.0000000000000285","article-title":"Celiac disease in women with infertility: a meta-analysis","volume":"50","author":"Singh P","year":"2016","journal-title":"J Clin Gastroenterol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1021956200382","article-title":"Changing presentation of adult celiac disease","volume":"48","author":"Lo W","year":"2003","journal-title":"Dig Dis Sci"},{"issue":"42","key":"ref9","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.3748\/wjg.v18.i42.6036","article-title":"Celiac disease: prevalence, diagnosis, pathogenesis and treatment","volume":"18","author":"Gujral N","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: systematic review and meta-analysis","volume":"16","author":"Singh P","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s10620-005-1291-z","article-title":"Celiac disease in the Turkish population","volume":"50","author":"Elsurer R","year":"2005","journal-title":"Dig Dis Sci"},{"issue":"9158","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(05)76459-X","article-title":"Iron-deficiency anaemia in premenopausal 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