{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:50:27Z","timestamp":1792515027425,"version":"4.5.0"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY The increase in bilirubin levels in newborns can cause toxic effects on the auditory system, which can lead to hearing loss. This review aimed to verify the impact of hyperbilirubinemia in the hearing of newborns, relating audiological findings to serum levels of bilirubin. A literature review was conducted during October 2017, using the terms \u201chyperbilirubinemia\u201d, \u201cjaundice\u201d, \u201cinfant\u201d, \u201cnewborn\u201d and \u201chearing loss\u201d, on databases CAPES journals, MEDLINE and BIREME (SciELO, BBO). 827 studies were identified and 59 were selected for full-text reading, resulting in the selection of seven articles that met the inclusion criteria and were considered relevant to the sample of this study. All the reviewed studies performed brainstem auditory evoked potential as the main test for audiological evaluation. Changes in the audiological findings of neonates with hyperbilirubinemia were observed in all studies. There was no consensus on the serum bilirubin levels that may cause auditory changes; however, the relationship between hearing disorders and blood levels of bilirubin was positive. We identify the need to establish reference values for bilirubin levels considered critical for the occurrence of hearing disorders as well as the audiological follow-up of neonates with hyperbilirubinemia.<\/jats:p>","DOI":"10.1590\/1806-9282.66.7.1002","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T20:39:58Z","timestamp":1598301598000},"page":"1002-1008","source":"Crossref","is-referenced-by-count":9,"title":["Hyperbilirubinemia impact on newborn hearing: a literature review"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-384X","authenticated-orcid":false,"given":"Marcela Hammes","family":"Teixeira","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-753X","authenticated-orcid":false,"given":"Viviann Magalh\u00e3es Silva","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-7532","authenticated-orcid":false,"given":"Rudimar dos Santos","family":"Riesgo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-407X","authenticated-orcid":false,"given":"Pricila","family":"Sleifer","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,7]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.siny.2014.12.006","article-title":"Audiologic impairment associated with bilirubin-induced neurologic damage","volume":"20","author":"Olds C","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.otoeng.2014.10.012","article-title":"The relationship between neonatal hyperbilirubinemia and sensorineural hearing loss","volume":"66","author":"Corujo-Santana C","year":"2015","journal-title":"Acta Otorrinolaringol Esp"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","DOI":"10.5812\/ircmj.18288","article-title":"Evaluation of auditory brain stems evoked response in newborns with pathologic hyperbilirubinemia in Mashhad, Iran","volume":"17","author":"Okhravi T","year":"2015","journal-title":"Iran Red Crescent Med J"},{"issue":"72","key":"ref4","first-page":"127","article-title":"The Relationship between the behavioral hearing thresholds and maximum bilirubin levels at birth in children with a history of neonatal hyperbilirubinemia","volume":"25","author":"Panahi R","year":"2013","journal-title":"Iran J Otorhinolaryngol"},{"key":"ref5","first-page":"5","article-title":"The relationship between severe hyperbilirubinemia and abnormal Auditory Brainstem Response in children","volume":"2","author":"Peyvandi AA","year":"2014","journal-title":"Int J Pediatr"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ijporl.2013.03.029","article-title":"Auditory risk of hyperbilirubinemia in term newborns: a systematic review","volume":"77","author":"Akinpelu OV","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.braindev.2013.03.003","article-title":"Impaired function of the auditory brainstem in term neonates with hyperbilirubinemia","volume":"36","author":"Jiang ZD","year":"2014","journal-title":"Brain Dev"},{"key":"ref8","article-title":"Hearing and neurological impairment in children with history of exchange transfusion for neonatal hyperbilirubinemia","volume":"2014","author":"Mart\u00ednez-Cruz CF","year":"2014","journal-title":"Int J Pediatr"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062858","article-title":"Evaluation of treatment thresholds for unconjugated hyperbilirubinemia in preterm infants: effects on serum bilirubin and on hearing loss?","volume":"8","author":"Hulzebos CV","year":"2013","journal-title":"PLoS One"},{"key":"ref10","series-title":"Cochrane handbook for systematic reviews of interventions Version 5.1.0. 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