{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:14:50Z","timestamp":1791224090599,"version":"4.1.0"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  Inflammation-related markers provide diagnostic and prognostic information for coronary artery disease and acute coronary syndrome. We aimed to compare neutrophil count and neutrophil\/lymphocyte ratio (NLR) in acute coronary syndrome patients with coronary collateral development in our study.  METHODS  A total of 426 patients (102 unstable angina pectoris (USAP), 223 non-ST-elevation myocardial infarction (non-STEMI), 103 ST-elevation myocardial infarction (STEMI) were compared regarding hemoglobin, platelet, lymphocyte, neutrophil count, and NLR.  RESULTS  Neutrophil count and NLR were significantly lower in USAP patients and higher in STEMI patients; 5.14\u00b1 1.79 vs. 7.21\u00b1 3.05 vs. 9.93\u00b14.67 and 2.92\u00b12.39 vs. 5.19\u00b14.80 vs. 7.93\u00b16.38, p &lt;0.001. Other parameters, i.e., hemoglobin, platelet, and lymphocyte count, were not significantly different between the groups.  CONCLUSIONS  In our study, it was concluded that there may be a statistically significant difference in the number of neutrophil counts and NLR among the types of acute coronary syndromes with coronary collateral development.<\/jats:p>","DOI":"10.1590\/1806-9282.66.7.954","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T16:39:13Z","timestamp":1598287153000},"page":"954-959","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of neutrophil and neutrophil\/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-1697","authenticated-orcid":false,"given":"Asli Kurtar","family":"Mansiroglu","sequence":"first","affiliation":[{"name":"Abant Izzet Baysal University Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2399-9585","authenticated-orcid":false,"given":"Isa","family":"Sincer","sequence":"additional","affiliation":[{"name":"Abant Izzet Baysal University Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-851X","authenticated-orcid":false,"given":"Yilmaz","family":"Gunes","sequence":"additional","affiliation":[{"name":"Abant Izzet Baysal University Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,7]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.15511\/ejcm.17.00467","article-title":"Correlations between hematological indicators and other known markers in acute coronary syndromes","volume":"5","author":"Ert\u00fcrk M","year":"2017","journal-title":"EJCM"},{"issue":"2","key":"ref2","first-page":"129","article-title":"Neutrophil-to-lymphocyte ratio predicts functionally significant coronary artery stenosis in patients with stable coronary artery disease","volume":"46","author":"Y\u0131lmaz S","year":"2018","journal-title":"Turk Kardiyol Dern Ars"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00059-015-4399-8","article-title":"Predictive and prognostic value of admission neutrophil-to-lymphocyte ratio in patients with CHD","volume":"41","author":"Yu C","year":"2016","journal-title":"Herz"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/S0735-1097(84)80126-6","article-title":"Temporal evolution of the human coronary collateral circulation after myocardial infarction","volume":"4","author":"Schwartz H","year":"1984","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ccd.21063","article-title":"Incidence and angiographic predictors of collateral function in patients with stable coronary artery disease scheduled for percutaneous coronary intervention","volume":"70","author":"de Vries J","year":"2007","journal-title":"Catheter Cardiovasc Interv"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0002-8703(81)90318-5","article-title":"The coronary collateral circulation: determinants and functional significance in ischemic heart disease","volume":"102","author":"Newman PE","year":"1981","journal-title":"Am Heart J"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<338::AID-PATH594>3.0.CO;2-7","article-title":"The pathophysiology of the collateral circulation (arteriogenesis)","volume":"190","author":"Buschmann I","year":"2000","journal-title":"J Pathol"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/S0735-1097(01)01675-8","article-title":"Frequency distribution of collateral flow and factors influencing collateral channel development. Functional collateral channel measurement in 450 patients with coronary artery disease","volume":"38","author":"Pohl T","year":"2001","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.amjcard.2012.04.041","article-title":"Relation of neutrophil\/lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergoing primary coronary intervention","volume":"110","author":"Akpek M","year":"2012","journal-title":"Am J Cardiol"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.amjcard.2008.05.006","article-title":"Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome","volume":"102","author":"Tamhane UU","year":"2008","journal-title":"Am J Cardiol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2014.03.003","article-title":"Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies","volume":"234","author":"Wang X","year":"2014","journal-title":"Atherosclerosis"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1590\/1806-9282.63.12.1065","article-title":"Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto\u2019s thyroiditis","volume":"63","author":"Aktas G","year":"2017","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"7-8","key":"ref13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00508-014-0683-5","article-title":"Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis?","volume":"127","author":"Posul E","year":"2015","journal-title":"Wien Klin Wochenschr"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0002-9149(88)91048-X","article-title":"Determinants and protective potential of coronary arterial collaterals as assessed by an angioplasty model","volume":"61","author":"Rentrop KP","year":"1988","journal-title":"Am J Cardiol"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/eurheartj\/ehs411","article-title":"Update on acute coronary syndromes: the pathologists\u2019 view","volume":"34","author":"Falk E","year":"2012","journal-title":"Eur Heart J"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.amjcard.2005.10.034","article-title":"Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention","volume":"97","author":"Duffy BK","year":"2006","journal-title":"Am J Cardiol"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1161\/01.ATV.0000039169.47943.EE","article-title":"B-lymphocyte deficiency increases atherosclerosis in LDL receptor\u2013null mice","volume":"22","author":"Major AS","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1161\/CIRCHEARTFAILURE.112.970525","article-title":"Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial","volume":"5","author":"Vaduganathan M","year":"2012","journal-title":"Circ Heart Fail"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0002-9149(00)00963-2","article-title":"Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris","volume":"86","author":"Zouridakis EG","year":"2000","journal-title":"Am J Cardiol"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/CIRCRESAHA.116.304944","article-title":"Coronary neutrophil extracellular trap burden and deoxyribonuclease activity in ST-elevation acute coronary syndrome are predictors of ST-segment resolution and infarct size","volume":"116","author":"Mangold A","year":"2015","journal-title":"Circ Res"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/hrt.2006.094763","article-title":"Association of haematological indices with the degree of microvascular injury in patients with acute anterior wall myocardial infarction treated with primary percutaneous coronary intervention","volume":"93","author":"Sezer M","year":"2007","journal-title":"Heart"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1161\/01.ATV.20.12.2553","article-title":"Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries","volume":"20","author":"Welt FG","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0735-1097(95)00524-2","article-title":"Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia","volume":"27","author":"Biasucci LM","year":"1996","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.amjcard.2007.11.004","article-title":"Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction","volume":"101","author":"N\u00fa\u00f1ez J","year":"2008","journal-title":"Am J Cardiol"},{"key":"ref25","article-title":"The neutrophil-lymphocyte ratio is associated with coronary artery calcification in asymptomatic Korean males: a cross-sectional study","volume":"2017","author":"Nam SH","year":"2017","journal-title":"Biomed Res Int"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/MCA.0000000000000500","article-title":"Prognostic value of coronary collaterals in patients with acute coronary syndromes","volume":"28","author":"Kurtul A","year":"2017","journal-title":"Coron Artery Dis"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v66n7\/1806-9282-ramb-66-7-0954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T19:41:14Z","timestamp":1611430874000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302020000700954&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["S0104-42302020000700954"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.66.7.954","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}