{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T19:06:47Z","timestamp":1744139207157,"version":"3.37.3"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE  To discuss the role of the benzodiazepine class in delirium patient management.  METHODS  Using the PubMed database, articles were reviewed after the year 2000 containing in their title the words \u2018delirium\u2019 and \u2018benzodiazepines\u2019.  DISCUSSION  Delirium is an acute confusional state that leads to altered attention, awareness, and cognition. It presents with some well-established risk factors, especially older individuals with cognitive decline. There is currently no definite consensus regarding its pathophysiology, nor regarding pharmacological measures, especially concerning the benzodiazepine class.  CONCLUSION  Evidence suggests that there may be a role for the use of pharmacological class in the treatment of this condition, indicating a change in the previously paradigmatic pattern of treatment.<\/jats:p>","DOI":"10.1590\/1806-9282.66.7.998","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T20:35:47Z","timestamp":1598301347000},"page":"998-1001","source":"Crossref","is-referenced-by-count":2,"title":["Benzodiazepinics and the treatment of delirium: a literature review"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-6361","authenticated-orcid":false,"given":"Ot\u00e1vio Henrique Polles","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Centro Universit\u00e1rio Inga,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-6822","authenticated-orcid":false,"given":"Gabriela Manfron","family":"Pellissari","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Inga,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-7906","authenticated-orcid":false,"given":"Henrique Soares","family":"Paiva","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil; USP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,7]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/CCM.0000000000002558","article-title":"Benzodiazepines and delirium in the young and old: truth be told or still not sold?","volume":"45","author":"Kudchadkar SR","year":"2017","journal-title":"Crit Care Med"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006379.pub3","article-title":"Benzodiazepines for delirium","author":"Lonergan E","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","series-title":"Comp\u00eandio de psiquiatria: ci\u00eancia do comportamento e psiquiatria cl\u00ednica","author":"Sadock BJ","year":"2016","edition":"11a"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1097\/CCM.0000000000003194","article-title":"Benzodiazepines and development of delirium in critically ill children: estimating the causal effect","volume":"46","author":"Mody K","year":"2018","journal-title":"Crit Care Med"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/CCM.0000000000002515","article-title":"Delirium and benzodiazepines associated with prolonged ICU stay in critically ill infants and young children","volume":"45","author":"Smith HAB","year":"2017","journal-title":"Crit Care Med"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/jamapsychiatry.2018.4365","article-title":"Association of delirium response and safety of pharmacological interventions for the management and prevention of delirium: a network meta-analysis","volume":"76","author":"Wu YC","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ebn1155","article-title":"Avoid benzodiazepines and opioids in people at risk of delirium","volume":"14","author":"Alldred DP","year":"2011","journal-title":"Evid Based Nurs"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"JC6","DOI":"10.7326\/0003-4819-154-12-201106210-02010","article-title":"Insufficient evidence exists about which drugs are associated with delirium; benzodiazepines may increase risk","volume":"154","author":"Carpenter CR","year":"2011","journal-title":"Ann Intern Med"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/SPC.0000000000000395","article-title":"Benzodiazepines for agitation in patients with delirium: selecting the right patient, right time, and right indication","volume":"12","author":"Hui D","year":"2018","journal-title":"Curr Opin Support Palliat Care"},{"key":"ref10","article-title":"ITU patients with delirium did not benefit from electronic and pharmacist support encouraging the deprescribing of benzodiazepines and anticholinergics","author":"Donaghy J","year":"2019","journal-title":"Evid Based Nurs"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.21037\/apm.2019.03.06","article-title":"Benzodiazepines and\/or neuroleptics for the treatment of delirium in palliative care? A critical appraisal of recent randomized controlled trials","volume":"8","author":"Gaertner J","year":"2019","journal-title":"Ann Palliat Med"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/EDE.0000000000000346","article-title":"An application of inverse probability weighting estimation of marginal structural models of a continuous exposure: benzodiazepines and delirium","volume":"26","author":"Hazelbag CM","year":"2015","journal-title":"Epidemiology"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1097\/CCM.0b013e31829824f0","article-title":"Benzodiazepines and delirium: the best option for the right patient","volume":"41","author":"Gusmao-Flores D","year":"2013","journal-title":"Crit Care Med"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1097\/CCM.0000000000003231","article-title":"On benzodiazepines, paradoxical agitation, hyperactive delirium, and chloride homeostasis","volume":"46","author":"Schieveld JNM","year":"2018","journal-title":"Crit Care Med"},{"edition":"50th","year":"2013","series-title":"Diagnostic and statistical manual of mental disorders (DSM\u20135)","key":"ref15"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ramb\/v66n7\/1806-9282-ramb-66-7-0998.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:45:45Z","timestamp":1611449145000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302020000700998&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":15,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["S0104-42302020000700998"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.66.7.998","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}