{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:52:48Z","timestamp":1790751168345,"version":"4.1.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  AIM  To describe the prevalence of dyslipidemia in children and adolescents with autoimmune rheumatic diseases (ARDs), particularly juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (jSLE), and juvenile dermatomyositis (JDM).  METHODS  Retrospective cross-sectional study conducted in the pediatric rheumatology outpatient clinic. We evaluated 186 children and adolescents between the ages of 5 and 19 years. The medical records were reviewed for the following data: demographic and clinical features, disease activity, and lipid profile (triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and very low density lipoprotein (VLDL-C)). In addition, non-HDL cholesterol was calculated as TC minus HDL-C. The cut-off points proposed by the American Academy of Pediatrics were used to classify the lipid profile.  RESULTS  Dyslipidemia was observed in 128 patients (68.8%), the most common being decreased HDL-C (74 patients, 39.8%). In the JIA group there was an association between the systemic subtype and altered LDL-C and NHDL-C, which demonstrated a more atherogenic profile in this subtype (p=0.027 and p=0.017, respectively). Among patients with jSLE, the cumulative corticosteroid dose was associated with an increase in LDL-C (p=0.013) and with a decrease in HDL-C (p=0.022).  CONCLUSION  Dyslipidemia is common in children and adolescents with ARDs, especially JIA, jSLE, and JDM, and the main alteration in the lipid profile of these patients was decreased HDL-C.<\/jats:p>","DOI":"10.1590\/1806-9282.66.8.1093","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T17:05:10Z","timestamp":1599843910000},"page":"1093-1099","source":"Crossref","is-referenced-by-count":11,"title":["Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3000-0314","authenticated-orcid":false,"given":"Wellington Douglas Rocha","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-0871","authenticated-orcid":false,"given":"Roseli Oselka Saccardo","family":"Sarni","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-9677","authenticated-orcid":false,"given":"Thais Tobaruela Ortiz","family":"Abad","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-0122","authenticated-orcid":false,"given":"Simone Guerra Lopes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-4752","authenticated-orcid":false,"given":"Fabiola Isabel Suano de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-1744","authenticated-orcid":false,"given":"Claudio Arnaldo","family":"Len","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-4296","authenticated-orcid":false,"given":"Maria Teresa","family":"Terreri","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/abc.20170121","article-title":"Atualiza\u00e7\u00e3o da Diretriz Brasileira de Dislipidemias e Preven\u00e7\u00e3o da Aterosclerose \u2013 2017","volume":"109","author":"Faludi AA","year":"2017","journal-title":"Arq Bras Cardiol"},{"key":"ref2","first-page":"658","article-title":"Avalia\u00e7\u00e3o do risco coronariano em mulheres com l\u00fapus eritematoso sist\u00eamico","volume":"49","author":"Cadaval RAM","year":"2009","journal-title":"Rev Bras Reumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/art.24091","article-title":"Differences in Long-Term Disease Activity and Treatment of Adult Patients With Childhood- and Adult-Onset Systemic Lupus Erythematosus","volume":"61","author":"Hersh AO","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref4","first-page":"10 67","article-title":"Metabolic syndrome in adults with a history of juvenile arthritis","author":"Sule S","year":"2018","journal-title":"Open Access Rheumatology: Research and Reviews"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jpeds.2011.05.015","article-title":"Clinical Status and Cardiovascular Risk Profile of Adults with a History of Juvenile Dermatomyositis","volume":"159","author":"Eimer MJ","year":"2011","journal-title":"J Pediatr"},{"key":"ref6","first-page":"509","article-title":"Inadequate dietary intake of children and adolescents with juvenile idiopathic arthritis and systemic lupus erythematosus","volume":"85","author":"Caetano MC","year":"2009","journal-title":"J Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000351076","article-title":"Dyslipidemia in pediatric systemic lupus erythematosus: The relationship with disease activity and plasma homocysteine and cysteine concentrations","volume":"63","author":"Ortiz TT","year":"2013","journal-title":"Ann Nutr Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00296-015-3393-z","article-title":"Lipid profile among girls with systemic lupus erythematosus","volume":"37","author":"Machado D","year":"2017","journal-title":"Rheumatol Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1177\/0961203317751851","article-title":"The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial","volume":"27","author":"Silva SGL","year":"2018","journal-title":"Lupus"},{"key":"ref10","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg MC","year":"1997","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymiositis and dermatomyositis","volume":"292","author":"Bohan A","year":"1975","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1542\/peds.2009-2107C","article-title":"Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary Report","volume":"128","author":"Articles S","year":"2011","journal-title":"Pediatrics"},{"key":"ref14","first-page":"2290","article-title":"Childhood Arthritis and Rheumatology Research Alliance, Pediatric Rheumatology International Trials Organization, Pediatric Rheumatology Collaborative Study Group. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis","volume":"31","author":"Wallace CA","year":"2004","journal-title":"J Rheumatol"},{"key":"ref15","first-page":"288","article-title":"Systemic lupus erythematosus disease activity index 2000","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/art.1780390303","article-title":"The development and initial validation of systemic lupus international collaborating clinics\/American College of Rheumatology Damage Index for systemic lupus erythematosus","volume":"39","author":"Gladman DD","year":"1996","journal-title":"Arthritis Rheum"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10067-015-3125-5","article-title":"Juvenile idiopathic arthritis activity and function ability: deleterious effects in periodontal disease?","volume":"35","author":"Pugliese 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serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis","volume":"37","author":"Cheng Y","year":"2014","journal-title":"Inflammation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1590\/S1807-59322011000900007","article-title":"Decreased high-density lipoprotein cholesterol levels in polyarticular juvenile idiopathic arthritis","volume":"66","author":"Marangoni RG","year":"2011","journal-title":"Clinics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2174\/1874192401105010064","article-title":"Dyslipidaemia in rheumatological autoimune diseases","volume":"5","author":"Toms TE","year":"2011","journal-title":"Open Cardiovascular Med J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1177\/0961203307079566","article-title":"Management of dyslipidemia in children and adolescents with systemic lupus erythematosus","volume":"16","author":"Ardoin 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