{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:41:52Z","timestamp":1763988112399,"version":"3.37.3"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: To describe the temporal trend, clinical profile, and the prevalence of risk factors and associated comorbidities in new cases of tuberculosis in the Northeast (2001-2016).  METHODS: A prevalence study involving all tuberculosis cases registered in Northeast Brasil, 2001-2016. Data were obtained from the National System of Notification of Disorders. For statistical analysis, the inflection point regression model and descriptive statistics were used.  RESULTS: 331,245 cases of tuberculosis were reported. The overall incidence rate decreased from 44.84\/100,000 inhabitants (2001) to 30.92\/100,000 inhabitants (2016), with a decreasing trend (AAPC: \u22122.3; p&lt;0.001). The profile was characterized by men (73.53%), age 20-59 years (73.56%), pulmonary tuberculosis (86.37%), positive smear microscopy (54.78%). The main risk factors and comorbidities were: AIDS (4.64%), HIV (12.10%), Diabetes mellitus (5.46%), alcohol (11.63%), institutionalized, (4.31%) and deprived of liberty (2.30%). The cure rate was 70.66% and the abandonment rate was 9.11%.  CONCLUSIONS: Even with a reduced incidence, tuberculosis represents a real public health problem in the Northeast region. The profile was characterized by a male population, in economically-active age, lung smear-positive pulmonary presentation, and the risk factors and comorbidities of Aids, TB\/HIV co-infection, diabetes mellitus, alcohol consumption, institutionalized and deprived of freedom reflect the complexity of the challenges in facing the disease.<\/jats:p>","DOI":"10.1590\/1806-9282.66.9.1196","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T18:52:28Z","timestamp":1601578348000},"page":"1196-1202","source":"Crossref","is-referenced-by-count":7,"title":["Tuberculosis in Northeastern Brasil (2001-2016): trend, clinical profile, and prevalence of risk factors and associated comorbidities"],"prefix":"10.1590","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4144-2361","authenticated-orcid":false,"given":"Alyne Barbosa","family":"Brito","sequence":"first","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-9845","authenticated-orcid":false,"given":"Williany Barbosa de","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-8920","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Silva de","family":"Paiva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-0866","authenticated-orcid":false,"given":"Thiago Cavalcanti","family":"Leal","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-6584","authenticated-orcid":false,"given":"Leonardo Feitosa da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-9594","authenticated-orcid":false,"given":"Lucas Gomes","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-8623","authenticated-orcid":false,"given":"Gibson Barros de Almeida","family":"Santana","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-2825","authenticated-orcid":false,"given":"T\u00e2nia Rita Moreno de Oliveira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-8254","authenticated-orcid":false,"given":"Carlos Dornels Freire de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,9]]},"reference":[{"year":"2017","series-title":"Guia de vigil\u00e2ncia em sa\u00fade","key":"ref1"},{"year":"2018","series-title":"Global tuberculosis report 2018","key":"ref2"},{"year":"2019","series-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade. 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