{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T11:25:25Z","timestamp":1648985125752},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>RESUMO:  Objetivo:  Estimar o volume de v\u00edrus circulante de HIV na popula\u00e7\u00e3o brasileira e avaliar o potencial impacto da terapia antirretroviral (HAART) na redu\u00e7\u00e3o de novas infec\u00e7\u00f5es, com o prop\u00f3sito de construir evid\u00eancias e informa\u00e7\u00f5es para subsidiar a implementa\u00e7\u00e3o de pol\u00edticas de sa\u00fade.  M\u00e9todos :  Ferramentas de an\u00e1lise espacial foram utilizadas para descrever os padr\u00f5es existentes na densidade da carga viral utilizando o m\u00e9todo Kernel qu\u00e1rtico. As informa\u00e7\u00f5es da carga viral e tratamento s\u00e3o oriundas da base conjunta do Sistema de Controle de Exames Laboratoriais (Siscel), com informa\u00e7\u00f5es do hist\u00f3rico da carga viral do indiv\u00edduo e do Sistema de Controle Log\u00edstico de Medicamentos (Siclom), que controla a dispensa dos medicamentos para a terapia antirretroviral.  Resultados:  Observou-se que a carga viral comunit\u00e1ria (CVC) apresentou redu\u00e7\u00e3o progressiva no per\u00edodo de 2007 a 2011, acompanhada de uma redu\u00e7\u00e3o da carga viral m\u00e9dia (CVCM) superior a 32% (22.900 c\u00f3pias\/mL em 2007 versus 15.418 c\u00f3pias\/mL em 2011). Nesse per\u00edodo, houve redu\u00e7\u00e3o da CVCM em todas as grandes regi\u00f5es do Brasil, embora o Norte e Nordeste tenham apresentado, respectivamente, CVCM 1,7 e 1,5 vezes a registrada no Sudeste. Em uma compara\u00e7\u00e3o entre os indiv\u00edduos que faziam ou n\u00e3o uso da HAART, observou-se aumento persistente da carga viral naqueles que n\u00e3o faziam uso da terapia de at\u00e9 3,9 vezes em 2011.  Conclus\u00e3o:  A abordagem apresentada neste estudo aponta a exist\u00eancia de aglomerados no espa\u00e7o com altas concentra\u00e7\u00f5es. O uso do Kernel na identifica\u00e7\u00e3o de aglomerados no espa\u00e7o mostrou-se um bom instrumento para an\u00e1lise explorat\u00f3ria, possibilitando a visualiza\u00e7\u00e3o do risco em determinadas \u00e1reas geogr\u00e1ficas sem as usuais divis\u00f5es pol\u00edtico-administrativas.<\/jats:p>","DOI":"10.1590\/1980-5497201600030009","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T16:09:54Z","timestamp":1478707794000},"page":"582-593","source":"Crossref","is-referenced-by-count":5,"title":["Carga viral comunit\u00e1ria do HIV no Brasil, 2007 - 2011: potencial impacto da terapia antirretroviral (HAART) na redu\u00e7\u00e3o de novas infec\u00e7\u00f5es"],"prefix":"10.1590","volume":"19","author":[{"given":"Artur Iuri Alves de","family":"Sousa","sequence":"first","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor Laerte","family":"Pinto J\u00fanior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJM200106073442306","article-title":"AIDS - the first 20 years","volume":"344","author":"Sepkowitz KA","year":"2001","journal-title":"N Engl J Med"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1002\/eji.201142082","article-title":"HIV\/AIDS 30 years of progress and future challenges","volume":"41","author":"Killian MS","year":"2011","journal-title":"Eur J Immunol"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2105\/AJPH.90.7.1037","article-title":"Tracking the HIV epidemic current issues, future challenges","volume":"90","author":"Fleming PL","year":"2000","journal-title":"Am J Public Health"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001260","article-title":"HIV treatment as prevention the utility and limitations of ecological observation","volume":"9","author":"Smith MK","year":"2012","journal-title":"PLoS Med"},{"key":"ref5","series-title":"Crit\u00e9rios de defini\u00e7\u00e3o de casos de AIDS em adultos e crian\u00e7as","year":"2004"},{"key":"ref6","series-title":"Minist\u00e9rio da Sa\u00fade. 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