{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:13:18Z","timestamp":1753888398172,"version":"3.41.2"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>ABSTRACT:  Introduction:  The mortality rate among tuberculosis patients (TB fatality) has been attributed to irregular chemotherapy, delay in diagnosis, multidrug resistance, and HIV coinfection.  Objective:  To analyze TB fatality rates by sex, clinical presentation and HIV coinfection in Campinas, S\u00e3o Paulo, Brazil.  Methods:  Cohorts of residents in the city of Campinas who either died during treatment for tuberculosis or had the disease confirmed after death were divided into three intervals: 2001-2003, 2004-2006, and 2007-2009. Data were obtained from the database of the Tuberculosis Surveillance System of the University of Campinas, and notifications were gathered through TB-WEB Health S\u00e3o Paulo Secretary. Statistical significance was determined using a chi-square test, considering p &lt; 0.05.  Results:  Between 2001 and 2009, 3,416 TB patients were diagnosed: 2,827 (82.8%) were new TB cases and 589 (17.2%) were retreatments. Between the first and second triennium, the number of new patients decreased by 18%, and 23% among retreatments. Between the second and third intervals, the reduction was 5% and 21%, respectively. General case fatality rate declined from 11.4% to 9.9% across intervals, and was most significant among patients that had previously abandoned treatment (17.3% to 5.1%). Fatality rates among patients coinfected with TB-AIDS were 2-3 times that of patients not infected with TB-AIDS throughout the intervals. Fatality between the first and third triennium among TB-AIDS co-infected patients declined (24.8% to 19.5%), while increasing slightly among non-AIDS TB patients (7.3% to 8%) during this period.  Conclusion:  Though mortality among TB-AIDS patients declined from 2001-2009, rates among non-AIDS TB remained stagnant. Improved TB diagnosis and treatment is needed to further decrease TB mortality in Campinas.<\/jats:p>","DOI":"10.1590\/1980-549720190043","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T20:02:32Z","timestamp":1566417752000},"source":"Crossref","is-referenced-by-count":0,"title":["Tuberculosis fatality rates in the city of Campinas - S\u00e3o Paulo, Brazil, from 2001 to 2009"],"prefix":"10.1590","volume":"22","author":[{"given":"Helenice Bosco de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-1173","authenticated-orcid":false,"given":"Let\u00edcia","family":"Marin-L\u00e9on","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-2765","authenticated-orcid":false,"given":"Nanci Michele","family":"Saita","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Eric","family":"Golub","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health,  United"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"year":"2012","series-title":"Global tuberculosis control: WHO report 2012","key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1164\/ajrccm\/144.4.745","article-title":"Resurgent tuberculosis in New York City: HIV, homelessness and the decline of TB control program","volume":"144","author":"Brudney K","year":"1991","journal-title":"Am Rev Resp 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P\u00fablica"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2334-11-1","article-title":"Factors associated with mortality in patients with drug-susceptible pulmonary tuberculosis","volume":"11","author":"Nahid P","year":"2011","journal-title":"BMC Infect Dis"},{"year":"2011","series-title":"Plano Nacional de Controle da Tuberculose 2011. Manual de recomenda\u00e7\u00f5es para o controle da tuberculose no Brasil","key":"ref23"}],"container-title":["Revista Brasileira de Epidemiologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rbepid\/v22\/1980-5497-rbepid-22-e190043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T21:06:35Z","timestamp":1581455195000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1415-790X2019000100443&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":23,"alternative-id":["S1415-790X2019000100443"],"URL":"https:\/\/doi.org\/10.1590\/1980-549720190043","relation":{},"ISSN":["1980-5497","1415-790X"],"issn-type":[{"type":"electronic","value":"1980-5497"},{"type":"print","value":"1415-790X"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e190043"}}