{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:02:17Z","timestamp":1784116937004,"version":"3.55.0"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>Resumo:   Objetivos:  Caracterizar a popula\u00e7\u00e3o do estudo, estimar a taxa de letalidade intra-hospitalar por estado e analisar fatores associados aos \u00f3bitos por COVID-19.   M\u00e9todos:  Foi realizado estudo de coorte retrospectiva de crian\u00e7as e adolescentes hospitalizados com diagn\u00f3stico de COVID-19 confirmado por transcri\u00e7\u00e3o reversa seguida de rea\u00e7\u00e3o em cadeia da polimerase (RT-PCR), tendo como desfecho \u00f3bito por COVID-19 ou recupera\u00e7\u00e3o, entre 1\u00ba de mar\u00e7o e 1\u00ba de agosto de 2020. A fonte de dados foi o Sistema de Informa\u00e7\u00e3o de Vigil\u00e2ncia Epidemiol\u00f3gica da Gripe (SIVEP-Gripe), ao qual s\u00e3o notificados pacientes internados com S\u00edndrome Respirat\u00f3ria Aguda Grave (SRAG). Consideraram-se crian\u00e7as os pacientes com idade entre 0 e 11 anos completos e adolescentes aqueles com idade entre 12 e 18 anos completos. Realizou-se an\u00e1lise bi e multivari\u00e1vel por meio de Regress\u00e3o de Poisson com vari\u00e2ncia robusta, utilizando-se como medida de associa\u00e7\u00e3o final o Risco Relativo ajustado (RRa).   Resultados:  Dos 4.930 casos analisados, 2.553 (51,8%) eram do sexo masculino. A ra\u00e7a\/cor autodeclarada parda foi a mais frequente, com 2.335 (47,4%). A unidade federativa de Roraima apresentou a maior taxa de letalidade intra-hospitalar, com 68,8% (n = 11\/16). A an\u00e1lise multivariada mostrou que pertencer ao grupo et\u00e1rio adolescente (RR = 1,59; IC95% 1,12 - 2,25; p = 0,009), ter sido classificado como SRAG-cr\u00edtico (RR = 4,56; IC95% 2,77 - 7,51; p &lt; 0,001) e apresentar imunopatia (RR = 2,24; IC95% 1,58 - 3,17; p &lt; 0,001) como comorbidade configuraram-se como fatores associados ao \u00f3bito pela COVID-19.   Conclus\u00e3o:  Observou-se que ser adolescente, ter classifica\u00e7\u00e3o de SRAG-cr\u00edtico e imunopatia como comorbidade foram importantes fatores associados ao \u00f3bito. Recomenda-se vigil\u00e2ncia ativa e cuidados diferenciados a portadores de doen\u00e7as cr\u00f4nicas e condi\u00e7\u00f5es imunol\u00f3gicas especiais.<\/jats:p>","DOI":"10.1590\/1980-549720200026","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:57:03Z","timestamp":1589245023000},"source":"Crossref","is-referenced-by-count":6,"title":["Coorte retrospectiva de crian\u00e7as e adolescentes hospitalizados por COVID-19 no Brasil do in\u00edcio da pandemia a 1\u00ba de agosto de 2020"],"prefix":"10.1590","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-164X","authenticated-orcid":false,"given":"Nivreanes Tcherno Nulle","family":"Gomes","sequence":"first","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-5491","authenticated-orcid":false,"given":"Maria Isabella Claudino","family":"Haslett","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-1060","authenticated-orcid":false,"given":"Ana Julia Silva e","family":"Alves","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-8105","authenticated-orcid":false,"given":"Jadher","family":"Percio","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-4406","authenticated-orcid":false,"given":"Magda Machado Saraiva","family":"Duarte","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-5081","authenticated-orcid":false,"given":"Juliane Maria Alves Siqueira","family":"Malta","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-3166","authenticated-orcid":false,"given":"Felipe Cotrim de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-6283","authenticated-orcid":false,"given":"Walquiria Aparecida Ferreira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-1715","authenticated-orcid":false,"given":"Caroline","family":"Gava","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-763X","authenticated-orcid":false,"given":"Libia Roberta de Oliveira","family":"Souza","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-2266","authenticated-orcid":false,"given":"Francieli Fontana Sutile Tardetti","family":"Fantinato","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-1590","authenticated-orcid":false,"given":"Elizabeth David dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","series-title":"COVID Reference","author":"Kamps BS","year":"2020"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu N","year":"2020","journal-title":"N Engl J Med"},{"key":"ref3","series-title":"Brasil. 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