{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:27:46Z","timestamp":1781602066784,"version":"3.54.5"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>RESUMO:  Introdu\u00e7\u00e3o:  Os benzodiazep\u00ednicos s\u00e3o os psicof\u00e1rmacos mais utilizados globalmente, apesar dos riscos associados ao seu uso prolongado, especialmente entre os idosos.  Objetivo:  O estudo teve como objetivo investigar a tend\u00eancia do uso de benzodiazep\u00ednicos entre idosos mais velhos (75 anos ou mais) residentes em comunidade.  M\u00e9todos:  Trata-se de um estudo realizado com idosos com idades entre 75 e 89 anos, integrantes da linha base (em 1997) e sobreviventes (em 2012) da coorte idosa do Projeto Bambu\u00ed. A preval\u00eancia do uso de benzodiazep\u00ednicos foi estimada separadamente para cada ano, e a compara\u00e7\u00e3o entre elas foi realizada por meio de regress\u00e3o de Poisson com vari\u00e2ncia robusta.  Resultados:  A preval\u00eancia do uso de benzodiazep\u00ednicos foi maior em 2012 (33,9%) em compara\u00e7\u00e3o a 1997 (24,9%). Ap\u00f3s o ajuste m\u00faltiplo, a diferen\u00e7a de preval\u00eancias n\u00e3o permaneceu significativa na popula\u00e7\u00e3o total de estudo (raz\u00e3o de preval\u00eancia (RP) = 1,25; intervalo de confian\u00e7a de 95% (IC95%) 0,99 - 1,60), diferentemente do observado no estrato feminino (RP = 1,38; IC95% 1,04 - 1,84). O clonazepam foi o medicamento que apresentou o mais forte crescimento (RP = 4,94; IC95% 2,54 - 9,62) entre os dois anos.  Conclus\u00e3o:  O presente estudo evidenciou um importante aumento no uso de benzodiazep\u00ednicos em uma popula\u00e7\u00e3o idosa mais velha. Esses resultados preocupam, pois s\u00e3o medicamentos contraindicados para idosos, especialmente se utilizados cronicamente, e est\u00e3o dispon\u00edveis na rela\u00e7\u00e3o nacional de medicamentos essenciais. Os profissionais de sa\u00fade devem estar atentos para os riscos envolvidos no seu uso por essa popula\u00e7\u00e3o.<\/jats:p>","DOI":"10.1590\/1980-549720200029","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:58:16Z","timestamp":1589245096000},"source":"Crossref","is-referenced-by-count":12,"title":["Aumento da utiliza\u00e7\u00e3o de benzodiazep\u00ednicos entre idosos mais velhos: Projeto Bambu\u00ed"],"prefix":"10.1590","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-727X","authenticated-orcid":false,"given":"Aline Luiza Marcondes Lopes","family":"Oliveira","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-4365","authenticated-orcid":false,"given":"Mariana Martins Gonzaga do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-5439","authenticated-orcid":false,"given":"\u00c9rico","family":"Castro-Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-9627","authenticated-orcid":false,"given":"Jos\u00e9lia Oliveira Ara\u00fajo","family":"Firmo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-2980","authenticated-orcid":false,"given":"Maria Fernanda","family":"Lima-Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-3477","authenticated-orcid":false,"given":"Ant\u00f4nio Ign\u00e1cio de","family":"Loyola Filho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11920-016-0727-9","article-title":"Benzodiazepine Misuse in the Elderly: Risk Factors, Consequences, and Management","volume":"18","author":"Airagnes G","year":"2016","journal-title":"Curr Psychiatry Rep"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.janxdis.2011.01.002","article-title":"The discovery of chlordiazepoxide and the clinical introduction of benzodiazepines: half a century of anxiolytic drugs","volume":"25","author":"Lopez-Mu\u00f1oz F","year":"2011","journal-title":"J Anxiety 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