{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:10:26Z","timestamp":1780729826362,"version":"3.54.1"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>ABSTRACT:  Introduction:  Brazil has registered more than 62,000 confirmed cases of leptospirosis between 2001 and 2017, with more than 2,000 cases confirmed in the State of Par\u00e1. Despite a large number of cases, no study has been conducted to trace the spatio-temporal profile of the disease.  Methodology:  Confirmed cases of leptospirosis from 2001 to 2017 from the state of Par\u00e1 were the basis for this space-time study. The database of the Department of Informatics of the Ministry of Health was used to access data on leptospirosis. The spatio-temporal analysis was performed in the SaTScan software for the detection of clusters, and maps were generated in the QGIS software.  Results:  The municipalities of Bel\u00e9m and Santar\u00e9m were among the ones with the highest incidence rates of leptospirosis for the whole study period. Increased number of cases in Soure, Inhangapi, S\u00e3o Jo\u00e3o da Ponta and Magalh\u00e3es Barata, Ponta de Pedras, Breves, Bragan\u00e7a, Castanhal, and S\u00e3o Domingos do Capim were identified in different time periods. Santar\u00e9m and Bel\u00e9m are the main foci of leptospirosis because they are the most urbanized and densely populated municipalities in the State. The cases found in smaller municipalities may be associated with periods of more frequent rainfall and circulation of Leptospira sp. in marsupials and cattle, in the northeastern part of the State.  Conclusion:  Further studies are needed to help identify the risk factors that contribute to the occurrence of leptospirosis in the State of Par\u00e1, particularly in areas with lower population density.<\/jats:p>","DOI":"10.1590\/1980-549720200041","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T12:39:27Z","timestamp":1591015167000},"source":"Crossref","is-referenced-by-count":3,"title":["Spatio-temporal analysis of leptospirosis in Eastern Amazon, State of Par\u00e1, Brazil"],"prefix":"10.1590","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-2534","authenticated-orcid":false,"given":"Rodrigo Arcoverde","family":"Cerveira","sequence":"first","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-0168","authenticated-orcid":false,"given":"Luan Oliveira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-1455","authenticated-orcid":false,"given":"Edwiges de F\u00e1tima de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-1832","authenticated-orcid":false,"given":"Hanna Katharine dos Santos","family":"Felipe","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-6608","authenticated-orcid":false,"given":"Marcelli Carolini Alves","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-7770","authenticated-orcid":false,"given":"Sandra Souza","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-5215","authenticated-orcid":false,"given":"Karla Tereza Silva","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5123\/S1679-49742011000400016","article-title":"Revis\u00e3o sistem\u00e1tica dos fatores associados \u00e0 leptospirose no Brasil, 2000-2009","volume":"20","author":"Pelissari DM","year":"2011","journal-title":"Epidemiol Serv Sa\u00fade"},{"issue":"1","key":"ref2","first-page":"49","article-title":"Fatores ambientais e socioecon\u00f4micos relacionados \u00e0 distribui\u00e7\u00e3o de casos de leptospirose no Estado de Pernambuco, Brasil, 2001-2009","volume":"20","author":"Vasconcelos CH","year":"2012","journal-title":"Cad Sa\u00fade Coletiva"},{"key":"ref3","series-title":"Esgotamento sanit\u00e1rio inadequado e impactos na sa\u00fade da Popula\u00e7\u00e3o","author":"Kronemberger D","year":"2010"},{"key":"ref4","first-page":"65","article-title":"Leptospirosis in humans","volume":"387","author":"Haake DA","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"issue":"1","key":"ref5","first-page":"59","article-title":"Probable areas of infection and ambience of occurrence of human leptospirosis in Brazil","volume":"57","author":"Arsky Mde L","year":"2005","journal-title":"Rev Cuba Med Trop"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"Costa F","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","series-title":". Censo Demogr\u00e1fico 2010: Aglomerados Subnormais 2011","year":"2010"},{"key":"ref8","series-title":"Guia de Vigil\u00e2ncia Epidemiol\u00f3gica: Normas e Manuais T\u00e9cnicos 2009","year":"2009"},{"key":"ref9","first-page":"3","article-title":"Estimativas preliminares da popula\u00e7\u00e3o urbana e rural segundo as unidades da federa\u00e7\u00e3o de 1960\/1980 por uma nova metodologia","volume":"33","author":"Madeira JL","year":"1972","journal-title":"Rev Bras Estat"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1757-1707.2012.01196.x","article-title":"Soil carbon stocks and changes after oil palm introduction in the Brazilian Amazon","volume":"5","author":"Fraz\u00e3o LA","year":"2013","journal-title":"Glob Change Biol Bioenergy"},{"key":"ref11","series-title":"SaTScan v9.6 Software for the spatial and space-time scan statistics","author":"Kulldorff M","year":"2009"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2105\/AJPH.88.9.1377","article-title":"Evaluating cluster alarms: A space-time scan statistic and brain cancer in Los Alamos, New Mexico","volume":"88","author":"Kulldorff M","year":"1998","journal-title":"Am J Public Health"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1080\/03610929708831995","article-title":"A spatial scan statistic","volume":"26","author":"Kulldorff M","year":"1997","journal-title":"Commun Stat Theory Methods"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/07474940902816601","article-title":"Power of the sequential Monte Carlo test","volume":"28","author":"Silva I","year":"2009","journal-title":"Seq Anal"},{"key":"ref15","series-title":"QGIS Geographic Information System","year":"2009"},{"key":"ref16","series-title":"Organiza\u00e7\u00e3o do Territ\u00f3rio","year":"2015"},{"issue":"4","key":"ref17","article-title":"Impact of environment and social gradient on Leptospira infection in urban slums","volume":"2","author":"Reis RB","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003338","article-title":"Influence of Household Rat Infestation on Leptospira Transmission in the Urban Slum Environment","volume":"8","author":"Costa F","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5894\/rgci122","article-title":"Efeitos da Expans\u00e3o Urbana nas Ilhas do Baixo Estu\u00e1rio do Amazonas: O Caso de Soure, Arquip\u00e9lago do Maraj\u00f3","volume":"9","author":"Menezes MOB","year":"2009","journal-title":"Rev Gest\u00e3o Costeira Integr"},{"key":"ref20","first-page":"2163","author":"Negr\u00e3o AMGN","year":"2015"},{"key":"ref21","first-page":"2184","author":"Negr\u00e3o AMGN","year":"2015"},{"key":"ref22","series-title":"BDMEP - Banco de Dados Meteorol\u00f3gicos Par\u00e1 Ensino e Pesquisa"},{"key":"ref23","series-title":"Perfil dos Munic\u00edpios Brasileiros","year":"2013"},{"key":"ref24","series-title":"Not\u00edcia Virtual InhInhangapi sedia 2\u00aa Feira de Vigil\u00e2ncia em Sa\u00fade","year":"2013"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1590\/0037-8682-0236-2017","article-title":"Detection of antibodies against Leptospira spp in free-living marsupials caught in the eastern Amazon","volume":"51","author":"Mesquita GS de S","year":"2018","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref26","series-title":"Fala periferia! Uma reflex\u00e3o sobre a produ\u00e7\u00e3o do espa\u00e7o perif\u00e9rico metropolitano","author":"Serpa A","year":"2001"}],"container-title":["Revista Brasileira de Epidemiologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rbepid\/v23\/1980-5497-rbepid-23-e200041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T19:47:41Z","timestamp":1611431261000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1415-790X2020000100438&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":26,"alternative-id":["S1415-790X2020000100438"],"URL":"https:\/\/doi.org\/10.1590\/1980-549720200041","relation":{},"ISSN":["1980-5497","1415-790X"],"issn-type":[{"value":"1980-5497","type":"electronic"},{"value":"1415-790X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e200041"}}