{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:20:32Z","timestamp":1779247232229,"version":"3.51.4"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>RESUMO:  Objetivo:  Analisar a evolu\u00e7\u00e3o, de 2011 a 2017, das taxas de detec\u00e7\u00e3o de s\u00edfilis notificada por sexo, faixa et\u00e1ria e regi\u00e3o de resid\u00eancia no estado de S\u00e3o Paulo (ESP).  M\u00e9todos:  Foi organizada s\u00e9rie hist\u00f3rica com dados do Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7\u00e3o (SINAN). Foram descritas as taxas de detec\u00e7\u00e3o de s\u00edfilis adquirida (TDSA) e de s\u00edfilis adquirida incluindo as gestantes com s\u00edfilis (TDSAG), por 100.000 hab. Para an\u00e1lise de tend\u00eancia da evolu\u00e7\u00e3o das taxas no per\u00edodo estudado, foi empregado o modelo Jointpoint (ponto de inflex\u00e3o), bem como foram estimadas a varia\u00e7\u00e3o percentual anual (VPA) por segmento e a m\u00e9dia da varia\u00e7\u00e3o percentual anual (MVPA), com os respectivos intervalos de confian\u00e7a de 95% (IC95%).  Resultados:  Foram notificados 205.424 casos de s\u00edfilis adquirida e s\u00edfilis em gestantes no per\u00edodo. Entre 2011 e 2017, a TDSA por 100 mil habitantes variou de 26,0 a 84,6 e a TDSAG por 100 mil habitantes, de 33,7 a 108,9; a tend\u00eancia foi crescente em ambas as curvas e identificou-se um ponto de inflex\u00e3o dividindo a curva de TDSA e de TDSAG em dois per\u00edodos: de 2011 a 2013 e de 2013 a 2017. A MVPA encontrada da TDSA foi de 21,0% (IC95% 15,7 \u2012 26,4) e da TDSAG, de 21,2% (IC95% 16,4 \u2012 -26,1). Nas faixas et\u00e1rias at\u00e9 24 anos ocorreu crescimento expressivo em ambos os sexos. Observou-se heterogeneidade na evolu\u00e7\u00e3o das taxas segundo regi\u00e3o do Estado.  Conclus\u00f5es:  A tend\u00eancia crescente das taxas de detec\u00e7\u00e3o de s\u00edfilis adquirida pode ser atribu\u00edda a melhor ades\u00e3o \u00e0 notifica\u00e7\u00e3o e ao acometimento desproporcional dos jovens.<\/jats:p>","DOI":"10.1590\/1980-549720200103","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T20:11:47Z","timestamp":1602533507000},"source":"Crossref","is-referenced-by-count":10,"title":["S\u00edfilis no estado de S\u00e3o Paulo, Brasil, 2011\u20122017"],"prefix":"10.1590","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-8594","authenticated-orcid":false,"given":"Carla Gianna","family":"Luppi","sequence":"first","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-1165","authenticated-orcid":false,"given":"Angela","family":"Tayra","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-9592","authenticated-orcid":false,"given":"Carmen Silvia Bruniera","family":"Domingues","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-0488","authenticated-orcid":false,"given":"Solange Eduardo Chabu","family":"Gomes","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6880-7607","authenticated-orcid":false,"given":"Valdir Monteiro","family":"Pinto","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-3075","authenticated-orcid":false,"given":"Maria Aparecida da","family":"Silva","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-0206","authenticated-orcid":false,"given":"Roberto Jos\u00e9 Carvalho da","family":"Silva","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-6283","authenticated-orcid":false,"given":"Mariza Vono","family":"Tancredi","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"6","key":"ref1","first-page":"1087","article-title":"Benzathine penicillin G in the treatment of syphilis","volume":"15","author":"Smith CA","year":"1956","journal-title":"Bull World Health Organ"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/CMR.19.1.29-49.2006","article-title":"Biological Basis for Syphilis","volume":"19","author":"LaFond RA","year":"2006","journal-title":"Clin Microbiol Rev"},{"issue":"10078","key":"ref3","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(16)32411-4","article-title":"Syphilis","volume":"389","author":"Hook 3rd EW","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1071\/SH14174","article-title":"Syphilis transmission: a review of the current evidence","volume":"12","author":"Stoltey JE","year":"2015","journal-title":"Sex Health"},{"issue":"3","key":"ref5","first-page":"34","article-title":"Sexually Transmitted Diseases Treatment Guidelines, 2015","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S1473-3099(04)01061-8","article-title":"Syphilis and HIV: a dangerous combination","volume":"4","author":"Lynn WA","year":"2004","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143304","article-title":"Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012","volume":"10","author":"Newman LM","year":"2015","journal-title":"PLos One"},{"key":"ref8","series-title":"Global Health Sector Strategy on sexually transmitted infections 2016-2021 towards ending STIs","year":"2016"},{"key":"ref9","series-title":"Portaria de Consolida\u00e7\u00e3o n\u00ba 4, de 28 de setembro de 2017. 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