{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:42:23Z","timestamp":1793367743548,"version":"4.5.0"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>ABSTRACT:  Objective: To analyze the characteristics and the factors associated with mortality of cases hospitalized for severe acute respiratory syndrome in a health region, in pre-pandemic and pandemic periods.  Methods: A retrospective documentary study of epidemiological surveillance carried out with secondary data from the Influenza Epidemiological Surveillance Information System, regarding the cases of patients belonging to a health region of Minas Gerais, Brazil.  Results: During the pandemic period, there was an increase in the number of hospitalizations and deaths due to severe acute respiratory syndrome, in addition to differences between sociodemographic and clinical-epidemiological characteristics. In both periods, the age and the use of invasive ventilatory support were the predictors of hospital mortality. The mortality in the pandemic period was also associated with male gender, presence of risk factors, admission to an intensive care unit, use of non-invasive ventilatory support, and infection by COVID-19.  Conclusions: In 2020, the detection rate of severe acute respiratory syndrome was 21 times higher than in 2019 and new symptoms, such as anosmia and ageusia, were included in their investigation. In both periods evaluated, elderly patients and patients on invasive mechanical ventilation had a higher risk of mortality. With the pandemic, there was a greater number of hospitalizations and factors associated with mortality.<\/jats:p>","DOI":"10.1590\/1980-549720210052","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T14:57:47Z","timestamp":1629471467000},"source":"Crossref","is-referenced-by-count":7,"title":["Hospitalizations and mortality by severe acute respiratory syndrome: comparison between the pre-pandemic and pandemic periods"],"prefix":"10.1590","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-644X","authenticated-orcid":false,"given":"Ana Cristina Dias","family":"Cust\u00f3dio","sequence":"first","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-0096","authenticated-orcid":false,"given":"F\u00e1bio Vieira","family":"Ribas","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9527-7325","authenticated-orcid":false,"given":"Luana Vieira","family":"Toledo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-6669","authenticated-orcid":false,"given":"Cristiane Junqueira de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-1577","authenticated-orcid":false,"given":"Luciana Moreira","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-0681","authenticated-orcid":false,"given":"Brunnella Alcantara Chagas de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","series-title":"Coronavirus Disease (COVID-19) situation reports [Internet]","year":"2020"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.jiph.2020.07.011","article-title":"The outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review of the current global status","volume":"13","author":"Bchetnia M","year":"2020","journal-title":"J Infect Public Health"},{"key":"ref3","series-title":"Folha informativa sobre COVID-19 \u2013 OPAS\/OMS|Organiza\u00e7\u00e3o Pan-Americana da Sa\u00fade","year":"2020"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.idc.2019.07.001","article-title":"Severe acute respiratory syndrome: historical, epidemiologic, and clinical features","volume":"33","author":"Hui DSC","year":"2019","journal-title":"Infect Dis Clin North Am"},{"key":"ref5","series-title":"Guia de vigil\u00e2ncia epidemiol\u00f3gica: emerg\u00eancia de sa\u00fade p\u00fablica de import\u00e2ncia nacional pela doen\u00e7a pelo Coronav\u00edrus 2019 \u2013 COVID-19","volume-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade","year":"2021"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S1473-3099(20)30484-9","article-title":"Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics","volume":"20","author":"Petersen E","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"552909","DOI":"10.3389\/fimmu.2020.552909","article-title":"Comparative review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza a respiratory viruses","volume":"11","author":"Abdelrahman Z","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3390\/v12111226","article-title":"COVID-19: look to the future, learn from the past","volume":"12","author":"Cheng ZJ","year":"2020","journal-title":"Viruses"},{"key":"ref9","series-title":"Macrorregi\u00e3o Sudeste","year":"2021"},{"issue":"5","key":"ref10","article-title":"Severe Acute Respiratory Syndrome due to COVID-19 among children and adolescents in Brazil: profile of deaths and hospital lethality as at epidemiological week 38","volume":"29","author":"Hillesheim D","year":"2020","journal-title":"Epidemiol Serv Saude"},{"key":"ref11","series-title":"Nota T\u00e9cnica n\u00b0 5 de 20 de maio de 2020","volume-title":"Monitora Covid-19 \u2013 FIOCRUZ. 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