{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:13:02Z","timestamp":1787926382880,"version":"build-2784847793"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>ABSTRACT  Objective: To analyze the spatial distribution and the temporal trend of the hepatitis mortality rate in Brazil from 2001 to 2020.  Methods: Ecological, temporal, and spatial study on mortality from hepatitis in Brazil with data from the Mortality Information System (Sistema de Informa\u00e7\u00f5es sobre Mortalidade \u2013 SIM\/DATASUS). Information was stratified by year of diagnosis, region of the country, municipalities (of residence). Standardized mortality rates (SMR) were calculated. The temporal trend was estimated by Prais-Winsten regression and the spatial distribution by the Global Moran Index (GMI).  Results: The highest SMR means in Brazil were for Chronic viral hepatitis with 0.88 deaths per 100,000 inhabitants (SD=0.16), followed by Other viral hepatitis with 0.22\/100,000 (SD=0.11). In Brazil, the temporal trend of mortality from Hepatitis A was \u22128.11% per year (95%CI \u22129.38; \u22126.82), while for Hepatitis B it was \u22124.13% (95%CI \u22126.03; \u22122.20), of Other viral hepatitis of \u22127.84% (95%CI \u221214.11; \u22121.11) and of Unspecified Hepatitis \u22125.67% per year (95%CI \u22126.22; \u22125.10). Mortality due to chronic viral hepatitis increased by 5.74% (95%CI 3.47; 8.06) in the North and 4.95% in the Northeast (95%CI 0.27; 9.85). The Moran Index (I) for Hepatitis A was 0.470 (p&lt;0.001), for Hepatitis B 0.846 (p&lt;0.001), Chronic viral hepatitis=0.666 (p&lt;0.001), other viral hepatitis=0.713 (p&lt;0.001), and Unspecified Hepatitis=0.712 (p&lt;0.001).  Conclusion: The temporal trend of hepatitis A, B, other viral, and unspecified hepatitis was decreasing in Brazil, while mortality from chronic hepatitis was increasing in the North and Northeast.<\/jats:p>","DOI":"10.1590\/1980-549720230029","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T09:18:09Z","timestamp":1688375889000},"source":"Crossref","is-referenced-by-count":3,"title":["Hepatitis mortality in Brazil and regions, 2001\u20132020: temporal trend and spatial analysis"],"prefix":"10.1590","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-4558","authenticated-orcid":false,"given":"Laryssa Fialho de Oliveira","family":"Sousa","sequence":"first","affiliation":[{"name":"Universidade Tiradentes,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-3443","authenticated-orcid":false,"given":"Evelen Rouse de Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Tiradentes,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5031-7204","authenticated-orcid":false,"given":"Rayssa Mendon\u00e7a","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Tiradentes,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-2311","authenticated-orcid":false,"given":"Renata Lima Batalha","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Tiradentes,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-7990","authenticated-orcid":false,"given":"Jefferson Felipe Calazans","family":"Batista","sequence":"additional","affiliation":[{"name":"Universidade Tiradentes,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3257-2412","authenticated-orcid":false,"given":"Sonia Oliveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Tiradentes,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","series-title":"Hepatologia","volume-title":"Guias de medicina ambulatorial e hospitalar","author":"Ferraz MLG","year":"2014"},{"issue":"3","key":"ref2","first-page":"206","article-title":"Hepatites virais: B, C e D: atualiza\u00e7\u00e3o","volume":"10","author":"Silva AL","year":"2012","journal-title":"Rev Bras Clin Med"},{"key":"ref3","series-title":"Global hepatitis report 2017","year":"2017"},{"issue":"2","key":"ref4","first-page":"81","article-title":"Tend\u00eancia temporal da incid\u00eancia de hepatite viral B e C no estado do Acre, no per\u00edodo de 2001 a 2013","volume":"3","author":"Fujimoto DE","year":"2019","journal-title":"D\u00eaCi\u00eancia em Foco"},{"key":"ref5","series-title":"Protocolo cl\u00ednico e diretrizes terap\u00eauticas para hepatite B e coinfec\u00e7\u00f5es","volume-title":"Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de DST, Aids e Hepatites Virais","year":"2019"},{"key":"ref6","series-title":"Boletim epidemiol\u00f3gico: hepatites virais [Internet]","volume-title":"Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade","year":"2021"},{"key":"ref7","series-title":"Programa Nacional de Hepatites Virais. Programa nacional de hepatites virais: avalia\u00e7\u00e3o da assist\u00eancia \u00e0s hepatites virais no Brasil","volume-title":"Minist\u00e9rio da Sa\u00fade. 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