{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:39:08Z","timestamp":1777563548413,"version":"3.51.4"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>ABSTRACT  Objective:  The aim of this study was to analyze the trends in incidence, mortality, and lethality rates due to meningitis in children and teenagers aged 0-19 years in Brazil and its regions by sex from 2002 to 2022.  Methods:  This is a time-series study of the cases and deaths due to meningitis with data from the Notifiable Diseases Information System. We estimated the average annual percent change (AAPC) and its 95% confidence interval (95%CI) via Joinpoint regression, in addition to comparing the Brazilian Federative Units\u2019 AAPCs by a pairwise coincidence test.  Results:  There were 274,500 cases and 17,162 deaths during the analyzed period, with downward trends both in Brazil and its regions regarding the incidence and mortality rates. In Brazil, the lowest AAPC in incidence was among males (AAPC=-5.7, 95%CI -7.1 to -4.2), whereas the lowest AAPC in mortality was among females (AAPC=-8.2, 95%CI -9.1 to -7.3). There were greater reductions in the incidence among males in all regions, except for the Central-West. Regarding the mortality rate, Northeast (AAPC=-9.6, 95%CI -10.6 to -8.5), South (AAPC=-8.1, 95%CI -9.8 to -6.3), and Central-West (AAPC=-8.5, 95%CI -10.7 to -6.3) showed their lowest AAPCs among females. There were significant differences in trends between males and females, mostly regarding incidence rates.  Conclusion:  Meningitis remains a concerning disease in Brazil, despite the downward trend in the country and its regions. It highlights the perpetuation of health inequalities, which reverberate in the levels of vaccination coverage and in the success of vaccination campaigns, impeding this disease\u2019s proper control.<\/jats:p>","DOI":"10.1590\/1980-549720250047","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T15:03:01Z","timestamp":1758294181000},"source":"Crossref","is-referenced-by-count":2,"title":["Trends in incidence, mortality, and lethality due to meningitis in children and teenagers in Brazil: a nationwide time-series study from 2002 to 2022"],"prefix":"10.1590","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1113-2167","authenticated-orcid":false,"given":"Alessandro Vidal de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade do Estado do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-3862","authenticated-orcid":false,"given":"Geovanna Barros","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1506-0236","authenticated-orcid":false,"given":"Ana Luiza Nepomuceno","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5221-4762","authenticated-orcid":false,"given":"Ana Lucy Peixoto","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","first-page":"33","article-title":"Perfil epidemiol\u00f3gico da meningite bacteriana no Munic\u00edpio de Vit\u00f3ria da Conquista - Bahia, no per\u00edodo de 2008 a 2015","volume":"17","author":"Magalh\u00e3es RS","year":"2018","journal-title":"Rev Ci\u00eanc M\u00e9d Biol"},{"issue":"6","key":"ref2","first-page":"530","article-title":"Meningites por Haemophilus influenzae b ap\u00f3s a implanta\u00e7\u00e3o da vacina espec\u00edfica","volume":"79","author":"Kmetzsch CI","year":"2003","journal-title":"J Pediatr (Rio J)"},{"issue":"2","key":"ref3","first-page":"25","article-title":"Incid\u00eancia de meningite na Regi\u00e3o Metropolitana de Goi\u00e2nia","volume":"3","author":"Fontaneli CR","year":"2006","journal-title":"Rev Eletr Farm [Internet]"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S1474-4422(18)30387-9","article-title":"Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref5","series-title":"Guia de Vigil\u00e2ncia em Sa\u00fade: volume 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Invest"},{"issue":"3","key":"ref9","first-page":"505","article-title":"Impacto da meningite entre os anos de 2010 a 2020 no Brasil: um estudo documental","volume":"21","author":"Moraes GFQ","year":"2022","journal-title":"Rev Ci\u00eanc M\u00e9d Biol"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/INF.0b013e3181e598ea","article-title":"Prospective cohort study of disabling sequelae and quality of life in children with bacterial meningitis in urban Senegal","volume":"29","author":"Edmond K","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"ref11","article-title":"The Brazilian national immunization program: 46 years of achievements and challenges","volume":"36","author":"Domingues CMAS","year":"2020","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"ref12","series-title":"Meningite (2001 a 2006): Casos confirmados notificados no Sistema de Informa\u00e7\u00e3o de Agravos de 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Gerais, Brazil: global space regressions","volume":"23","author":"Gusm\u00e3o JD","year":"2023","journal-title":"BMC Infect Dis"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3201\/eid2005.130948","article-title":"Carriage rate and effects of vaccination after outbreaks of serogroup C meningococcal disease, Brazil, 2010","volume":"20","author":"S\u00e1fadi MAP","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/14760584.2023.2211163","article-title":"Understanding barriers to vaccination against invasive meningococcal disease: a survey of the knowledge gap and potential solutions","volume":"22","author":"Ballalai I","year":"2023","journal-title":"Expert Rev Vaccines"},{"issue":"38","key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5712\/rbmfc11(38)1122","article-title":"Cobertura da vacina meningoc\u00f3cica C nos estados e regi\u00f5es do Brasil em 2012","volume":"11","author":"Neves RG","year":"2016","journal-title":"Rev Bras Med Fam Comunidade"},{"key":"ref26","article-title":"Meningitis in childhood: an analysis of hospital hospitalizations in Brazil","volume":"7","author":"Santos JC","year":"2021","journal-title":"Rev Cient Esc Estadual Sa\u00fade P\u00fablica Goi\u00e1s \u201cC\u00e2ndido Santiago\u201d"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"102158","DOI":"10.1016\/j.parint.2020.102158","article-title":"Eosinophilic meningitis outbreak related to religious practice","volume":"78","author":"Monteiro MD","year":"2020","journal-title":"Parasitol Int"},{"key":"ref28","series-title":"Vigil\u00e2ncia das pneumonias e meningites bacterianas em crian\u00e7as menores de 5 anos: Guia pr\u00e1tico","year":"2020"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1590\/S0034-89102004000500008","article-title":"Impacto da vacina\u00e7\u00e3o contra o Haemophilus 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J"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062390","article-title":"Sex bias in infectious disease epidemiology: patterns and processes","volume":"8","author":"Guerra-Silveira F","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.immuni.2023.10.008","article-title":"Sex hormone signaling and regulation of immune function","volume":"56","author":"Hoffmann JP","year":"2023","journal-title":"Immunity"}],"container-title":["Revista Brasileira de Epidemiologia"],"original-title":["Tend\u00eancia da incid\u00eancia, da mortalidade e da letalidade de meningite em crian\u00e7as e adolescentes no Brasil: um estudo nacional de s\u00e9ries temporais de 2002 a 2022"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1415-790X2025000100439&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T15:03:07Z","timestamp":1758294187000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1415-790X2025000100439&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"alternative-id":["S1415-790X2025000100439"],"URL":"https:\/\/doi.org\/10.1590\/1980-549720250047","relation":{},"ISSN":["1980-5497","1415-790X"],"issn-type":[{"value":"1980-5497","type":"electronic"},{"value":"1415-790X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e250047"}}