{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:58:58Z","timestamp":1785506338606,"version":"3.56.0"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"crossref","award":["400943\/2013-1"],"award-info":[{"award-number":["400943\/2013-1"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Science and Technology of the Brazilian Ministry of Health\/National Council for Scientific and Technological Development","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Department of Science and Technology of the Brazilian Ministry of Health\/National Council for Scientific and Technological Development","award":["400943\/2013-1"],"award-info":[{"award-number":["400943\/2013-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. bras. epidemiol."],"abstract":"<jats:p>ABSTRACT  Objective:  To investigate the association between age at menarche and blood pressure in adolescence, and to examine the role of body adiposity in this relationship.  Methods:  This was a cross-sectional analysis nested within a population-based birth cohort conducted in S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil. The study included 885 female adolescents aged 18-19 years. Age at menarche was self-reported. Systolic and diastolic blood pressure were measured using a validated digital device, and body adiposity was assessed by air displacement plethysmography. Pearson correlation coefficients were estimated, and linear regression models were used to evaluate the association between age at menarche and blood pressure, with sequential adjustment for socioeconomic, behavioral, family, and perinatal factors, followed by additional adjustment for body adiposity.  Results:  Age at menarche showed weak inverse correlations with systolic and diastolic blood pressure and a negative correlation with body adiposity. Body adiposity, in turn, was positively correlated with both systolic and diastolic blood pressure. In adjusted models, age at menarche remained significantly associated with blood pressure after controlling for socioeconomic, behavioral, family, and perinatal factors; however, these associations were attenuated and lost statistical significance after additional adjustment for body adiposity.  Conclusion:  The association between age at menarche and blood pressure in adolescence appears to be largely influenced by body adiposity, highlighting the importance of considering body composition when evaluating cardiovascular risk related to pubertal timing.<\/jats:p>","DOI":"10.1590\/1980-549720260038","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:03:04Z","timestamp":1785502984000},"source":"Crossref","is-referenced-by-count":0,"title":["Age at menarche and blood pressure in late adolescence: the role of body adiposity in a Brazilian birth cohort"],"prefix":"10.1590","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0924-9031","authenticated-orcid":false,"given":"Juliana Jansen","family":"Santos","sequence":"first","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-2763","authenticated-orcid":false,"given":"Janielle Ferreira de Brito","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-0959","authenticated-orcid":false,"given":"Maria Luziene de Sousa","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-7222","authenticated-orcid":false,"given":"Kayo Elmano Costa da Ponte","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8399-2868","authenticated-orcid":false,"given":"Dannyel Rogger Almeida","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8222-4430","authenticated-orcid":false,"given":"Lua Beatriz Nascimento","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-5156","authenticated-orcid":false,"given":"Rita da Gra\u00e7a Carvalhal Fraz\u00e3o","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil; Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-0165","authenticated-orcid":false,"given":"Ros\u00e2ngela Fernandes Lucena","family":"Batista","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","series-title":"Problems of adolescent health: report of a WHO expert committee","year":"1965"},{"issue":"3","key":"ref2","first-page":"195","article-title":"Secular trend of age at menarche evaluated in relation to body mass index","volume":"56","author":"Castilho SD","year":"2012","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref3","series-title":"Idade de menarca, excesso de peso e obesidade: estilos de vida na adolesc\u00eancia","author":"Madeira TAB","year":"2017"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jpag.2018.05.004","article-title":"Puberty, menarche, and the menstrual cycle: what do we know, and what do we teach?","volume":"31","author":"Hillard PJA","year":"2018","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/nbu.12544","article-title":"Age at menarche and its association with overweight including obesity and socioeconomic conditions of Brazilian schoolgirls: a time-trend analysis","volume":"47","author":"Matsuo LH","year":"2022","journal-title":"Nutr Bull"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/ijerph17051703","article-title":"A systematic literature review of factors affecting the timing of menarche: the potential for climate change to impact women\u2019s health","volume":"17","author":"Canel\u00f3n SP","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2020-003689","article-title":"Timing and determinants of age at menarche in low-income and middle-income countries","volume":"5","author":"Leone T","year":"2020","journal-title":"BMJ Glob Health"},{"issue":"35","key":"ref8","first-page":"53","article-title":"Influ\u00eancia da Classe socioecon\u00f4mica, tamanho da fam\u00edlia e antropometria na idade da menarca","volume":"10","author":"Farias ES","year":"2020","journal-title":"Perspectivas Online: Biol\u00f3gicas & Sa\u00fade"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1475-2840-13-22","article-title":"Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)","volume":"13","author":"Mueller NT","year":"2014","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/GME.0000000000001289","article-title":"Age at menarche and risk of all-cause and cardiovascular mortality: a systematic review and dose-response meta-analysis","volume":"26","author":"Chen X","year":"2018","journal-title":"Menopause"},{"issue":"12","key":"ref11","article-title":"Age at menarche and risk of cardiovascular disease outcomes: findings from the National Heart Lung and Blood Institute-Sponsored Women\u2019s Ischemia Syndrome Evaluation","volume":"8","author":"Lee JJ","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/GME.0000000000001653","article-title":"Age at menarche and cardiovascular health: results from NHANES 1999-2016","volume":"28","author":"Zheng Y","year":"2020","journal-title":"Menopause"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/qjmed\/hcac187","article-title":"Long-term health outcomes of early menarche in women: an umbrella review","volume":"115","author":"Lee JS","year":"2022","journal-title":"QJM"},{"key":"ref14","series-title":"DATASUS. 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