{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:52:43Z","timestamp":1760100763781},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement. neuropsychol."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases. He described Senile dementia, a highly heterogeneous condition, and was able not only to distinguish it from syphilitic brain disease, but also to discriminate two clinicopathological subtypes, that may be labeled a \"arteriosclerotic subtype\", comparable to the present clinicopathological continuum of \"Vascular cognitive impairment\", and another as a \"neurodegenerative subtype\", characterized by primary [cortical] ganglion cell [nerve cells] degeneration, possibly foreshadowing a peculiar presenile disease that he was to describe some years later and would carry his name. He also considered the possibility of a senile presentation of this disease subtype, which was described by Oskar Fischer a short time later. Considering the clinicopathological overlapping features of the \"arteriosclerotic subtype\" of Senile dementia with Arteriosclerotic atrophy of the brain, it might be possible to consider that both represent a single condition.<\/jats:p>","DOI":"10.1590\/1980-57642015dn92000013","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T22:07:59Z","timestamp":1436047679000},"page":"184-188","source":"Crossref","is-referenced-by-count":5,"title":["Alzheimer and vascular brain disease: Senile dementia"],"prefix":"10.1590","volume":"9","author":[{"given":"Eliasz","family":"Engelhardt","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[{"name":"University of California, USA; Universidade de Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"146","article-title":"Uber eine eigenartige Erkrankung derHirnrinde","volume":"64","author":"Alzheimer A","year":"1907","journal-title":"Allg Z Psychiat phychish-gerichtliche"},{"key":"ref2","series-title":"Psychiatrie: ein Lehrbuch f\u00fcr Studierende und \u00c4rzte","volume":"II","author":"Kraepelin E"},{"key":"ref3","first-page":"627","year":"1910"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1590\/S1980-57642015DN91000013","article-title":"Alzheimer and vascular brain disease: the Arteriosclerotic atrophy of the brain","volume":"9","author":"Engelhardt E","year":"2015","journal-title":"Dement Neuropsychol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-510X(98)00128-2","article-title":"History of dementia and dementia in history: an overview","volume":"158","author":"Boller 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