{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:03:58Z","timestamp":1767650638183},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends Psychiatry Psychother."],"abstract":"<jats:p>Introduction: Malariotherapy was a treatment to cure neurosyphilis developed in 1917 by Wagner-Jauregg, by inoculating blood infected with malaria in patients with neurosyphilis. The patient had febrile episodes that often cured him of the syphilitic infection. This treatment won the Nobel Prize in Medicine in 1927 and it was introduced in Hospital Psiqui\u00e1trico S\u00e3o Pedro (HPSP) in 1929.Methods: This is a descriptive retrospective cross-sectional study with collection of historical secondary data. Data were collected from a sample of 19 medical records of patients treated with malariotherapy in HPSP, in 1929 and 1930.Results: Most patients were white men aged from 25 to 40 years. The mean length of hospital stay was 1.4 year and the outcomes at this early application of malariotherapy were mostly negative (63.2% died).Discussion: The 19 cases evaluated in this study refer to the first year of application of malariotherapy in HPSP. The statistics available on the total number of dead and cured people over the 10 years this therapy was deployed suggest that the outcomes were better in the subsequent years, possibly due to improvement of technique. As a consequence of this innovative research, which had as its principle reorganizing the central nervous system by using the seizure triggered by malaria fever, other forms of shock therapies were developed, such as insulin therapy, cardiazol shock therapy, and electroconvulsive therapy.<\/jats:p>","DOI":"10.1590\/2237-6089-2013-0063","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T16:34:26Z","timestamp":1410194066000},"page":"169-172","source":"Crossref","is-referenced-by-count":1,"title":["Profile of patients treated with malariotherapy in a psychiatric hospital in Porto Alegre, Brazil: a historical note"],"prefix":"10.1590","volume":"36","author":[{"given":"Guilherme Astor","family":"Torres","sequence":"first","affiliation":[{"name":"PUCRS,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena Itaqui","family":"Lopes","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Ga\u00facha de Hist\u00f3ria da Medicina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson Medeiros","family":"Cheuiche","sequence":"additional","affiliation":[{"name":"Hospital Psiqui\u00e1trico S\u00e3o Pedro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Gustavo","family":"Guilhermano","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade do Rio Grande do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2014,9,9]]},"reference":[{"key":"ref1","first-page":"151","article-title":"A malarioterapia no tratamento da neuross\u00edfilis","author":"Mattos SG","year":"2010","journal-title":"P\u00e1ginas da hist\u00f3ria da medicina"},{"key":"ref2","first-page":"7","article-title":"Um tratamento de choque: a aplica\u00e7\u00e3o da malarioterapia no Hospital do Juquery (1925-1940)","volume":"5","author":"Tarelow GQ","year":"2009","journal-title":"Cad Hist Cienc Inst Butantan"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1176\/appi.ajp.2008.08081271","article-title":"Julius Wagner-Jauregg, 1857-1940","volume":"166","author":"Howes OD","year":"2009","journal-title":"Am J Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0957154X09338085","article-title":"Malaria fever therapy for general paralysis of the insane in Denmark","volume":"21","author":"Kragh JV","year":"2010","journal-title":"Hist Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/10398560903295717","article-title":"Syphilis, sex and psychiatry, 1789-1925: Part 2","volume":"18","author":"Kaplan RM","year":"2010","journal-title":"Australas Psychiatry"},{"key":"ref6","first-page":"516","article-title":"The history of malariotherapy for neurosyphilis","volume":"268","author":"Austin SC","year":"1992","journal-title":"Modern parallels"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S1516-44461999000100007","article-title":"Tratamento etiol\u00f3gico em psiquiatria: o modelo da neuross\u00edfilis","volume":"21","author":"Gastal FL","year":"1999","journal-title":"Rev Bras Psiquiatr"},{"key":"ref8","series-title":"S\u00edfilis e paralisis general progresiva. Tratado de Neurologia","first-page":"773","author":"Litter M","year":"1952","edition":"5\u00aa"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005053-192205000-00001","article-title":"The treatment of general paresis by inoculation of malaria","volume":"55","author":"Wagner-Jauregg J","year":"1922","journal-title":"J Nerv Ment Dis"},{"key":"ref10","series-title":"Estudo estat\u00edstico da malarioterapia","author":"Louzada P","year":"1939"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1590\/S0037-86822000000500007","article-title":"Gonorr\u00e9ia","volume":"33","author":"Penna GO","year":"2000","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref12","first-page":"7","article-title":"Um tratamento de choque: a aplica\u00e7\u00e3o da malarioterpia no Hospital do Juquery (1925-1940)","volume":"5","author":"Tarelow GQ","year":"2009","journal-title":"Cad Hist Cienc Inst Butantan"},{"key":"ref13","first-page":"335","article-title":"Sistemas de medicina","author":"Gottschall CAM","year":"2013","journal-title":"Encontros com a hist\u00f3ria da medicina"}],"container-title":["Trends in Psychiatry and Psychotherapy"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/trends\/v36n3\/2237-6089-trends-2237-6089-2013-0063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T23:57:48Z","timestamp":1520294268000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S2237-60892014000300169&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,9]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,9]]}},"alternative-id":["S2237-60892014000300169"],"URL":"https:\/\/doi.org\/10.1590\/2237-6089-2013-0063","relation":{},"ISSN":["2238-0019","2237-6089"],"issn-type":[{"value":"2238-0019","type":"electronic"},{"value":"2237-6089","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,9]]}}}