{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:09:47Z","timestamp":1762506587359},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends Psychiatry Psychother."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Objective: To report the rare development of manic symptoms in a patient with schizophrenia and discuss its differential diagnosis.Case description: Diagnostic criteria were based on the International Classification of Diseases, 10th edition (ICD-10). A 63-year-old female (diagnosed with schizophrenia since she was 28) was brought to the emergency room with symptoms consistent with manic episode and physical examination suggestive of thyrotoxicosis. Graves' disease was confirmed by subsequent laboratory tests. She was treated successfully with radioiodine ablation, leading to full remission of manic symptoms.Comments: Schizophrenia is a chronic disease that affects about 1% of the population worldwide. The main symptoms of the disorder are altered affection, delusions, and hallucinations. Graves' disease is an autoimmune condition in which antibodies increase the production and release of thyroid hormones. There are reports about the development of mood symptoms in patients with Graves' disease that remit with adequate treatment.<\/jats:p>","DOI":"10.1590\/2237-6089-2014-0053","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T23:30:17Z","timestamp":1437867017000},"page":"100-103","source":"Crossref","is-referenced-by-count":2,"title":["Where does her mood come from? An organic approach to a once functional patient"],"prefix":"10.1590","volume":"37","author":[{"given":"Pablo Eduardo Pereira","family":"Dutra","sequence":"first","affiliation":[{"name":"Centro Psiqui\u00e1trico do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner de Sousa","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Centro Psiqui\u00e1trico do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Alves","family":"Higa","sequence":"additional","affiliation":[{"name":"Centro Psiqui\u00e1trico do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Costa","sequence":"additional","affiliation":[{"name":"C\u00edrculo Psicanal\u00edtico do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1756-0500-5-169","article-title":"Inter-relationship of plasma markers of oxidative stress and thyroid hormones in schizophrenics","volume":"5","author":"Akiibinu MO","year":"2012","journal-title":"BMC Res Notes"},{"key":"ref2","first-page":"516","article-title":"Newly observed affection of the thyroid gland in females","volume":"7","author":"Graves RJ","year":"1835","journal-title":"Lond Med Surg J"},{"key":"ref3","first-page":"897","article-title":"Psychiatric manifestations of Graves' hyperthyroidism, pathophysiology and treatment options","volume":"20","author":"Bunevicius R","year":"2006","journal-title":"CNS Drugs"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/SMJ.0b013e3180f62916","article-title":"Psychiatric manifestations of thyroid disease","volume":"100","author":"Peiris AN","year":"2007","journal-title":"South Med J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"183.e1","DOI":"10.1016\/j.amjmed.2009.06.030","article-title":"Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease","volume":"123","author":"Boelaert K","year":"2010","journal-title":"Am J Med"},{"key":"ref6","series-title":"Stahl's essential psychopharmacology: neuroscientific basis and practical applications","first-page":"168","volume-title":"Psychosis and schizophrenia","author":"Stahl SM","year":"2010","edition":"3"},{"key":"ref7","series-title":"Stahl's essential psychopharmacology: neuroscientific basis and practical applications","first-page":"218","volume-title":"Antipsychotic drugs","author":"Stahl SM","year":"2010","edition":"3"},{"key":"ref8","series-title":"The American psychiatric publishing textbook of psychiatry","first-page":"431","volume-title":"Schizophrenia","author":"Minzenberg MJ","year":"2012","edition":"5th"},{"key":"ref9","first-page":"411","article-title":"Optimal iodine-131 dose for eliminating hyperthyroidism in Graves' disease","volume":"32","author":"Nordyke RA","year":"1991","journal-title":"J Nucl Med"},{"key":"ref10","series-title":"Endocrinology: adult and pediatric. 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