{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:49:04Z","timestamp":1789501744986,"version":"build-2803163510"},"reference-count":69,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends Psychiatry Psychother."],"abstract":"<jats:p>Objective: To compile data on Tourette's syndrome (TS), tics and associated disorders.Methods: A systematic review of the literature was conducted using the 5S levels of organization of healthcare research evidence (systems, summaries, synopses, syntheses, studies), based on the model described by Haynes. The search keywords were Tourette, tics and comorbidity, which were cross-referenced. Studies provided by publishers and articles being processed on July 31, 2013, were also included.Results: Of all studies retrieved during the search, 64 were selected because they analyzed the epidemiology, clinical features and etiopathogenesis of TS and its comorbidities. TS is classified as a hyperkinetic movement disorder, and at least 90% of the patients have neuropsychiatric comorbidities, of which attention deficit hyperactivity and obsessive-compulsive disorders are the most common. The syndrome is clinically heterogeneous and has been associated with a dysfunction of cortico-striatal-thalamic-cortical circuits involving various neurotransmitters. Although its genetic etiology has been widely studied, other factors may be important to understand this syndrome and its associated disorders.Conclusions: TS is a neurodevelopmental disorder that results from the impact of stress factors on a vulnerable biological substrate during the critical periods of neurodevelopment. The study of TS and its comorbidities may contribute, at different levels, to the understanding of several neuropsychiatric disorders of clinical and therapeutic relevance.<\/jats:p>","DOI":"10.1590\/2237-6089-2014-1003","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T04:18:31Z","timestamp":1407644311000},"page":"123-133","source":"Crossref","is-referenced-by-count":13,"title":["Tourette's syndrome and associated disorders: a systematic review"],"prefix":"10.1590","volume":"36","author":[{"given":"B\u00e1rbara R.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Coimbra Hospital and University Centre,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Pio-Abreu","sequence":"additional","affiliation":[{"name":"Coimbra Hospital and University Centre,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Janu\u00e1rio","sequence":"additional","affiliation":[{"name":"Coimbra Hospital and University Centre,  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1176\/jnp.2009.21.1.13","article-title":"The behavioral spectrum of Gilles de la Tourette syndrome","volume":"21","author":"Cavanna AE","year":"2009","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1875-9572(10)60050-2","article-title":"Tourette syndrome in children: an updated review","volume":"51","author":"Du JC","year":"2010","journal-title":"Pediatr Neonatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1056\/NEJMra010032","article-title":"Tourette's syndrome","volume":"345","author":"Jankovic J","year":"2001","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00004583-200301000-00016","article-title":"Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment","volume":"42","author":"Sukhodolsky DG","year":"2003","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jpsychores.2008.03.006","article-title":"The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies","volume":"65","author":"Robertson MM","year":"2008","journal-title":"J Psychosom Res"},{"key":"ref6","first-page":"473","article-title":"The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes","volume":"65","author":"Robertson MM","year":"2008","journal-title":"J Psychosom Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0006-3223(95)00221-9","article-title":"Elevated cerebrospinal fluid corticotropin-releasing factor in Tourette's syndrome: comparison to obsessive compulsive disorder and normal controls","volume":"39","author":"Chappell P","year":"1996","journal-title":"Biol Psychiatry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/archpsyc.1994.03950100030003","article-title":"Elevated cerebrospinal fluid levels of oxytocin in obsessive-compulsive disorder. Comparison with Tourette's syndrome and healthy controls","volume":"51","author":"Leckman JF","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1017\/S095457940404458X","article-title":"Testing the prenatal hormone hypothesis of tic-related disorders: gender identity and gender role behavior","volume":"16","author":"Alexander GM","year":"2004","journal-title":"Dev Psychopathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ajmg.b.30550","article-title":"A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary report","volume":"144B","author":"Lit L","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00787-007-0671-7","article-title":"Locus of control, perceived parenting style, and symptoms of anxiety and depression in children with Tourette's syndrome","volume":"17","author":"Cohen E","year":"2008","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jpsychores.2006.07.019","article-title":"Mood disorders and Gilles de la Tourette's syndrome: An update on prevalence, etiology, comorbidity, clinical associations, and implications","volume":"61","author":"Robertson MM","year":"2006","journal-title":"J Psychosom Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/ebm.11.6.162-a","article-title":"Of studies, syntheses, synopses, summaries, and systems: the \"5S\" evolution of information services for evidence-based healthcare decisions","volume":"11","author":"Haynes RB","year":"2006","journal-title":"Evid Based Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1600-0404.2007.00879.x","article-title":"Schizotypal personality traits in Gilles de la Tourette syndrome","volume":"116","author":"Cavanna AE","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00004583-200005000-00009","article-title":"Anxiety disorders and tic severity in juveniles with Tourette's disorder","volume":"39","author":"Coffey BJ","year":"2000","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.2001.tb05773.x","article-title":"Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders","volume":"931","author":"Comings DE","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"ref17","first-page":"S122","article-title":"Comorbid disorders associated with tics.","volume":"34","author":"Fern\u00e1ndez-Alvarez E","year":"2002","journal-title":"Rev Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.braindev.2009.01.005","article-title":"Association between Tourette syndrome and comorbidities in Japan","volume":"32","author":"Kano Y","year":"2010","journal-title":"Brain Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00787-007-1007-3","article-title":"The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit\/hyperactivity disorder","volume":"16","author":"Sukhodolsky DG","year":"2007","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref20","first-page":"11","article-title":"Comorbid disorders of the attention deficit with hyperactivity disorder.","volume":"35","author":"Pascual-Castroviejo I","year":"2002","journal-title":"Rev Neurol"},{"key":"ref21","first-page":"331","article-title":"Tourette's syndrome and attention-deficit hyperactivity disorder: evidence for a genetic relationship","volume":"54","author":"Knell ER","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1097\/01.chi.0000251211.36868.fe","article-title":"A controlled family study of attention-deficit\/hyperactivity disorder and Tourette's disorder","volume":"45","author":"Stewart SE","year":"2006","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuroimage.2006.03.056","article-title":"Increased event-related theta activity as a psychophysiological marker of comorbidity in children with tics and attention-deficit\/hyperactivity disorders","volume":"32","author":"Yordanova J","year":"2006","journal-title":"Neuroimage"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1469-8749.2008.03014.x","article-title":"Are amygdalar volume alterations in children with Tourette syndrome due to ADHD comorbidity","volume":"50","author":"Ludolph AG","year":"2008","journal-title":"Dev Med Child Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/sj.mp.4001144","article-title":"A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry","volume":"7","author":"Nordstrom EJ","year":"2002","journal-title":"Mol Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archpsyc.57.4.364","article-title":"Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit\/hyperactivity disorders","volume":"57","author":"Peterson BS","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1176\/ajp.2006.163.6.1066","article-title":"Association between maternal smoking and increased symptom severity in Tourette's syndrome","volume":"163","author":"Mathews CA","year":"2006","journal-title":"Am J Psychiatry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/CHI.0b013e3181af825a","article-title":"Sleep and tics: problems associated with ADHD","volume":"48","author":"Taylor E","year":"2009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4088\/JCP.v59n1103","article-title":"Rage attacks in children and adolescents with Tourette's disorder: a pilot study","volume":"59","author":"Budman CL","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"ref30","first-page":"94","article-title":"Prevalence and comorbidity of tic disorder in Israeli adolescents: results from a national mental health survey","volume":"15","author":"Steinberg T","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"ref31","first-page":"259","article-title":"Disruptive behaviour, hyperactivity, and learning disabilities in children with Tourette's syndrome","volume":"65","author":"Walkup JT","year":"1995","journal-title":"Adv Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2431-5-34","article-title":"Tourette Syndrome and learning disabilities","volume":"5","author":"Burd L","year":"2005","journal-title":"BMC Pediatr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1001\/archpsyc.61.12.1259","article-title":"Habit learning in Tourette syndrome: a translational neuroscience approach to a developmental psychopathology","volume":"61","author":"Marsh R","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-8993(00)02646-9","article-title":"Glutamatergic drugs exacerbate symptomatic behavior in a transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder","volume":"15;877","author":"McGrath MJ","year":"2000","journal-title":"Brain Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1017\/S1092852900023014","article-title":"Early onset obsessive-compulsive disorder with and without tics","volume":"14","author":"de Mathis MA","year":"2009","journal-title":"CNS Spectr"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1017\/S1092852900013791","article-title":"Obsessive-compulsive disorder with and without tic disorder: a comparative study from India","volume":"13","author":"Jaisoorya TS","year":"2008","journal-title":"CNS Spectr"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4088\/JCP.v61n0213","article-title":"Sensory phenomena in obsessive-compulsive disorder and Tourette's disorder","volume":"61","author":"Miguel EC","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1017\/S1092852912000491","article-title":"Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study","volume":"17","author":"Gomes de Alvarenga P","year":"2012","journal-title":"CNS Spectr"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.psychres.2004.05.007","article-title":"Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates","volume":"128","author":"Hemmings SM","year":"2004","journal-title":"Psychiatry Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/ajmg.b.30699","article-title":"Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review","volume":"147B","author":"Bloch MH","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2005.05.031","article-title":"Serotonin transporter binding in Tourette Syndrome","volume":"385","author":"M\u00fcller-Vahl KR","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/da.20597","article-title":"Early onset of obsessive-compulsive disorder and associated comorbidity","volume":"26","author":"Janowitz D","year":"2009","journal-title":"Depress Anxiety"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00787-003-0342-2","article-title":"Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder: --Findings from an Indian study","volume":"12","author":"Jaisoorya TS","year":"2003","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S0033291706008816","article-title":"Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins","volume":"37","author":"Bolton D","year":"2007","journal-title":"Psychol Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0888-7543(03)00097-1","article-title":"CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder","volume":"82","author":"Verkerk AJ","year":"2003","journal-title":"Genomics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ajmg.a.30066","article-title":"Candidate locus for Gilles de la Tourette syndrome\/obsessive compulsive disorder\/chronic tic disorder at 18q22","volume":"130A","author":"Cuker A","year":"2004","journal-title":"Am J Med Genet A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/archpsyc.60.4.415","article-title":"Basal Ganglia volumes in patients with Gilles de la Tourette syndrome","volume":"60","author":"Peterson BS","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1177\/070674379904401010","article-title":"Aggressive behaviour in children with Tourette syndrome and comorbid attention-deficit hyperactivity disorder and obsessive-compulsive disorder","volume":"44","author":"Stephens RJ","year":"1999","journal-title":"Can J Psychiatry"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00787-002-0301-3","article-title":"Obsessive compulsive behaviour and depressive symptoms in young people with Tourette syndrome. A controlled study","volume":"11","author":"Robertson MM","year":"2002","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1607-551X(09)70564-9","article-title":"Diagnosis and treatment of comorbidities of Tourette's syndrome and bipolar disorder in a 10-year-old boy","volume":"25","author":"Wang PW","year":"2009","journal-title":"Kaohsiung J Med Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1176\/ajp.152.11.1646","article-title":"Comorbid Tourette's disorder and bipolar disorder: an etiologic perspective","volume":"152","author":"Kerbeshian J","year":"1995","journal-title":"Am J Psychiatry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0006-3223(97)00025-5","article-title":"Bipolar disorder in adult patients with Tourette's syndrome: a clinical study","volume":"43","author":"Berthier ML","year":"1998","journal-title":"Biol Psychiatry"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1469-7610.2007.01729.x","article-title":"Sleep patterns in children with attention-deficit\/hyperactivity disorder, tic disorder, and comorbidity","volume":"48","author":"Kirov R","year":"2007","journal-title":"J Child Psychol Psychiatry"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ajmg.b.30047","article-title":"Variants of the orexin2\/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity","volume":"129B","author":"Thompson MD","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/08830738050200060301","article-title":"Clinical significance of tics and attention-deficit hyperactivity disorder (ADHD) in children with pervasive developmental disorder","volume":"20","author":"Gadow KD","year":"2005","journal-title":"J Child Neurol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1017\/S003329179900896X","article-title":"The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study","volume":"29","author":"Baron-Cohen S","year":"1999","journal-title":"Psychol Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1469-7610.00434","article-title":"The prevalence of Gilles de la Tourette's syndrome in children and adolescents with autism","volume":"40","author":"Baron-Cohen S","year":"1999","journal-title":"J Child Psychol Psychiatry"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s007870200003","article-title":"Early-onset Tourette syndrome with reversible autistic behaviour: a dysmaturational disorder","volume":"11","author":"Zappella M","year":"2002","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.janxdis.2007.10.003","article-title":"Autism spectrum traits in children and adolescents with obsessive-compulsive disorder (OCD)","volume":"22","author":"Ivarsson T","year":"2008","journal-title":"J Anxiety Disord"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jpsychores.2009.08.002","article-title":"Tourette syndrome and comorbid early-onset schizophrenia","volume":"67","author":"Kerbeshian J","year":"2009","journal-title":"J Psychosom Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0278-5846(02)00260-9","article-title":"Comorbidity of Tourette's syndrome and schizophrenia-biological and physiological parallels","volume":"26","author":"M\u00fcller N","year":"2002","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archneur.61.4.606-b","article-title":"Migraine and Tourette syndrome","volume":"61","author":"Barbanti P","year":"2004","journal-title":"Arch Neurol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1007\/s10072-012-1042-9","article-title":"Migraine and movement disorders","volume":"33","author":"d'Onofrio F","year":"2012","journal-title":"Neurol Sci"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0891-4222(94)00018-5","article-title":"Tardive or atypical Tourette's disorder in a population with Down syndrome","volume":"16","author":"Myers B","year":"1995","journal-title":"Res Dev Disabil"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/mds.21995","article-title":"Fragile X syndrome associated with tic disorders","volume":"23","author":"Schneider SA","year":"2008","journal-title":"Mov Disord"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.genhosppsych.2007.10.001","article-title":"Diogenes syndrome in a patient with obsessive-compulsive disorder without hoarding","volume":"30","author":"Fontenelle LF","year":"2008","journal-title":"Gen Hosp Psychiatry"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/appi.ajp.160.7.1356","article-title":"Tourette's-like syndrome and dementia","volume":"160","author":"Stewart JT","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1176\/appi.ajp.157.3.481-a","article-title":"Tourette's syndrome and mycoplasma pneumoniae infection","volume":"157","author":"M\u00fcller N","year":"2000","journal-title":"Am J Psychiatry"},{"key":"ref69","series-title":"Elementos de psicopatologia explicativa","author":"Pio-Abreu JL","year":"2012","edition":"1"}],"container-title":["Trends in Psychiatry and Psychotherapy"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/trends\/v36n3\/2237-6089-trends-2237-6089-2014-1003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T23:57:48Z","timestamp":1520294268000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S2237-60892014000300123&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,12]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,9]]}},"alternative-id":["S2237-60892014000300123"],"URL":"https:\/\/doi.org\/10.1590\/2237-6089-2014-1003","relation":{},"ISSN":["2238-0019","2237-6089"],"issn-type":[{"value":"2238-0019","type":"electronic"},{"value":"2237-6089","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,12]]}}}