{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:52:29Z","timestamp":1719237149395},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends Psychiatry Psychother."],"abstract":"<jats:p>Abstract  Introduction  Clozapine is a well-recognized effective treatment for some patients with treatment-resistant schizophrenia (TRS). Although it has potential benefits and approximately 30% of patients have a clinical indication for clozapine use, prescription rates are low.  Objective  To evaluate clozapine prescription trends over a 5-year period in a tertiary psychiatric hospital.  Methods  In this observational study, data prospectively collected by the Medical and Statistical File Service (Servi\u00e7o de Arquivo M\u00e9dico e Estat\u00edstico) and the Pharmacy Division of Instituto de Psiquiatria de Santa Catarina between January 2010 and December 2014 were summarized and analyzed by investigators blinded to data collection. The number of 100 mg clozapine pills dispensed by the Pharmacy Division to the inpatient units was the outcome and considered a proxy measure of clozapine prescriptions. The number of occupied inpatient unit beds and the number of patients admitted with F20-F29 (ICD-10) diagnoses during the study period were considered to be possible confounders.  Results  A multiple linear regression model showed that time in months was independently associated with an increase in the number of clozapine pills dispensed by the Pharmacy Division (\u03b2 coefficient = 15.82; 95% confidence interval 10.88-20.75).  Conclusion  Clozapine prescriptions were found to have increased during the 5-year period studied, a trend that is opposite to reports from several other countries.<\/jats:p>","DOI":"10.1590\/2237-6089-2016-0053","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T23:16:57Z","timestamp":1501370217000},"page":"158-164","source":"Crossref","is-referenced-by-count":2,"title":["Trends in the prescription of clozapine in a psychiatric hospital: a 5-year observational study"],"prefix":"10.1590","volume":"39","author":[{"given":"Gabriela Danielski","family":"Niehues","sequence":"first","affiliation":[{"name":"Instituto de Psiquiatria de Santa Catarina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Balestieri","family":"Balan","sequence":"additional","affiliation":[{"name":"Instituto de Psiquiatria de Santa Catarina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius Brum","family":"Pr\u00e1","sequence":"additional","affiliation":[{"name":"Instituto de Psiquiatria de Santa Catarina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaela Santos","family":"Pellizzaro","sequence":"additional","affiliation":[{"name":"Instituto de Psiquiatria de Santa Catarina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto Antunes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Danielski","family":"Niehues","sequence":"additional","affiliation":[{"name":"Universidade do Sul de Santa Catarina,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Costa","sequence":"additional","affiliation":[{"name":"UFSC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Liborio","family":"Schwarzbold","sequence":"additional","affiliation":[{"name":"UFSC,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Paim","family":"Diaz","sequence":"additional","affiliation":[{"name":"UNISUL,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1176\/ajp.2006.163.4.600","article-title":"Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment","volume":"163","author":"McEvoy JP","year":"2006","journal-title":"Am J Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(13)60733-3","article-title":"Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments 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