{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T21:17:22Z","timestamp":1774300642559,"version":"3.50.1"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends Psychiatry Psychother."],"abstract":"<jats:p>Abstract  Introduction  The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote neurogenesis. Hippocampal atrophy has been related to bipolar disorder (BD) in preclinical, imaging and postmortem studies. Therefore, the development of new strategies to stimulate the neurogenesis process in BD is crucial.  Objectives  To investigate the behavioral and neurochemical changes induced by transplantation of MSCs in a model of mania-like behavior induced by lisdexamfetamine dimesylate (LDX).  Methods  Wistar rats (n=65) received one oral daily dose of LDX (10 mg\/kg) or saline for 14 days. On the 8th day of treatment, the animals additionally received intrahippocampal saline or MSC (1 \u00b5L containing 25,000 cells) or lithium (47.5 mg\/kg) as an internal experimental control. Two hours after the last administration, behavioral and neurochemical analyses were performed.  Results  LDX-treated rats had increased locomotor activity compared to saline-saline rats (p=0.004), and lithium reversed LDX-related hyperactive behavior (p&lt;0.001). In contrast, the administration of MSCs did not change hyperlocomotion, indicating no effects of this treatment on LDX-treated rats (p=0.979). We did not find differences between groups in BDNF levels (p&gt;0.05) in the hippocampus of rats.  Conclusion  Even though these results suggest that a single intrahippocampal injection of MSCs was not helpful to treat hyperactivity induced by LDX and neither influenced BDNF secretion, we cannot rule out the possible therapeutic effects of MSCs. Further research is required to determine direct effects of LDX on brain structures as well as in other pathophysiological targets related to BD.<\/jats:p>","DOI":"10.1590\/2237-6089-2016-0074","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T15:50:25Z","timestamp":1494949825000},"page":"196-201","source":"Crossref","is-referenced-by-count":3,"title":["Cell therapy in the treatment of bipolar mania in an animal model: a proof of concept study"],"prefix":"10.1590","volume":"39","author":[{"given":"Bruna M.","family":"Ascoli","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil; Universidade Federal do Rio Grande do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Colombo","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil; Universidade de Caxias do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza P.","family":"G\u00e9a","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil; UFRGS,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula B.","family":"Terraciano","sequence":"additional","affiliation":[{"name":"HCPA,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina B.","family":"Pizzato","sequence":"additional","affiliation":[{"name":"HCPA,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda S.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"HCPA,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Cirne-Lima","sequence":"additional","affiliation":[{"name":"HCPA,  Brazil; UFRGS,  Brazil; UFRGS,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio","family":"Kapczinski","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil; Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane R.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil; Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil; UFRGS,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jpsychires.2012.02.004","article-title":"Neurobiological correlates of illness progression in the recurrent affective disorders","volume":"46","author":"Post RM","year":"2012","journal-title":"J Psychiatr 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