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adults","volume":"70","author":"Littley MD","year":"1989","journal-title":"Q J Med"},{"issue":"5","key":"ref81","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0360-3016(96)00586-X","article-title":"Symptom resolution, tumor control, and side effects following postoperative radiotherapy for pituitary macroadenomas","volume":"37","author":"Rush S","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2265.2008.03464.x","article-title":"Neurocognitive consequences of surgery and radiotherapy for tumours of the pituitary","volume":"70","author":"Tooze A","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"ref83","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1210\/jc.2004-1152","article-title":"Risk of second brain tumor after conservative surgery and radiotherapy for pituitary adenoma: update after an additional 10 years","volume":"90","author":"Minniti G","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref84","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11102-007-0083-1","article-title":"Mortality following pituitary radiotherapy","volume":"12","author":"Ayuk J","year":"2009","journal-title":"Pituitary"},{"issue":"3","key":"ref85","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0360-3016(99)00159-5","article-title":"The incidence of cerebrovascular accidents in patients with pituitary adenoma","volume":"45","author":"Brada M","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"ref86","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1210\/jc.2002-020526","article-title":"Risk factors for cerebrovascular deaths in patients operated and irradiated for pituitary tumors","volume":"87","author":"Erfurth EM","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"9254","key":"ref87","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group","volume":"357","author":"Tomlinson JW","year":"2001","journal-title":"Lancet"},{"issue":"10","key":"ref88","doi-asserted-by":"crossref","first-page":"E1938","DOI":"10.1210\/jc.2012-2432","article-title":"Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma","volume":"97","author":"Zueger T","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref89","first-page":"996","article-title":"Radiosurgery for pituitary adenomas","volume":"50","author":"Castro DG","year":"2006","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"6","key":"ref90","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3171\/jns.2006.104.6.876","article-title":"Gamma surgery in the treatment of nonsecretory pituitary macroadenoma","volume":"104","author":"Mingione V","year":"2006","journal-title":"J Neurosurg"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11060-013-1262-8","article-title":"Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and radiation therapy","volume":"117","author":"Ding D","year":"2014","journal-title":"J Neurooncol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000056444","article-title":"A six year experience with the postoperative radiosurgical management of pituitary adenomas","volume":"72","author":"Mokry M","year":"1999","journal-title":"Stereotact Funct Neurosurg"},{"issue":"3","key":"ref93","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11060-009-9832-5","article-title":"Stereotactic radiosurgery for pituitary adenomas: a comprehensive review of indications, techniques and long-term results using the Gamma Knife","volume":"92","author":"Jagannathan J","year":"2009","journal-title":"J Neurooncol"},{"issue":"2","key":"ref94","first-page":"284","article-title":"Adrenocorticotropic hormone-producing pituitary tumors: 12- to 22-year follow-up after treatment with stereotactic radiosurgery","volume":"49","author":"Hoybye C","year":"2001","journal-title":"Neurosurgery"},{"issue":"4","key":"ref95","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1677\/ERC-08-0181","article-title":"Medical therapy for clinically non-functioning pituitary adenomas","volume":"15","author":"Colao A","year":"2008","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"ref96","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1210\/jc.2008-1826","article-title":"Expression analysis of dopamine receptor subtypes in normal human pituitaries, nonfunctioning pituitary adenomas and somatotropinomas, and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acromegaly","volume":"94","author":"Neto LV","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref97","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1385\/ENDO:14:3:329","article-title":"Dopamine D2 receptor gene expression in human adenohypophysial adenomas","volume":"14","author":"Stefaneanu L","year":"2001","journal-title":"Endocrine"},{"issue":"4","key":"ref98","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1210\/jc.2003-030859","article-title":"Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors: comparison with the effectiveness of cabergoline treatment","volume":"89","author":"Pivonello R","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref99","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/cen.12684","article-title":"Dopamine receptor subtype 2 expression profile in nonfunctioning pituitary adenomas and in vivo response to cabergoline therapy","volume":"82","author":"Vieira Neto L","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"ref100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2265.2005.02295.x","article-title":"Postoperative treatment of clinically nonfunctioning pituitary adenomas with dopamine agonists decreases tumour remnant growth","volume":"63","author":"Greenman Y","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1210\/edrv-13-2-220","article-title":"Dopamine agonists and pituitary tumor shrinkage","volume":"13","author":"Bevan JS","year":"1992","journal-title":"Endocr Rev"},{"issue":"3","key":"ref102","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1210\/jcem-64-3-536","article-title":"Luteinizing hormone-secreting pituitary tumor: biosynthetic characterization and clinical studies","volume":"64","author":"Klibanski A","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref103","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1210\/jcem-61-3-580","article-title":"Follicle-stimulating hormone- and alpha-subunit-secreting pituitary tumor treated with bromocriptine","volume":"61","author":"Vance ML","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"ref104","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1210\/jcem.84.7.5810","article-title":"Cabergoline in the treatment of hyperprolactinemia: a study in 455 patients","volume":"84","author":"Verhelst J","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref105","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000184630","article-title":"Comparison among different dopamine-agonists of new formulation in the clinical management of macroprolactinomas","volume":"44","author":"Colao A","year":"1995","journal-title":"Horm Res"},{"issue":"1","key":"ref106","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1056\/NEJMoa062222","article-title":"Dopamine agonists and the risk of cardiac-valve regurgitation","volume":"356","author":"Schade R","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"ref107","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11102-011-0339-7","article-title":"A comparison of cabergoline and bromocriptine on the risk of valvular heart disease in patients with prolactinomas","volume":"15","author":"Boguszewski CL","year":"2012","journal-title":"Pituitary"},{"issue":"2","key":"ref108","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/S0004-27302011000200001","article-title":"Recommendations of Neuroendocrinology Department from Brazilian Society of Endocrinology and Metabolism for diagnosis and treatment of acromegaly in Brazil","volume":"55","author":"Vieira Neto L","year":"2011","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"1","key":"ref109","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/eje.1.02313","article-title":"Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas","volume":"156","author":"Taboada GF","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"ref110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1530\/EJE-07-0562","article-title":"Quantitative analysis of somatostatin receptor subtypes (1-5) gene expression levels in somatotropinomas and correlation to in vivo hormonal and tumor volume responses to treatment with octreotide LAR","volume":"158","author":"Taboada GF","year":"2008","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"ref111","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1590\/S0004-27302008000800014","article-title":"Somatostatin receptors subtypes 2 and 5, dopamine receptor type 2 expression and gsp status as predictors of octreotide LAR responsiveness in acromegaly","volume":"52","author":"Vieira Neto L","year":"2008","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"6","key":"ref112","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0026-895X(25)13664-X","article-title":"Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides","volume":"43","author":"Raynor K","year":"1993","journal-title":"Mol Pharmacol"},{"issue":"2","key":"ref113","first-page":"398","article-title":"Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors","volume":"78","author":"Greenman Y","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"ref114","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/c55f4d48-d393-4ff5-b363-c9fc85bfbd93","article-title":"ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas","volume":"8","author":"Vieira Neto L","year":"2013","journal-title":"PloS one"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000079048","article-title":"Somatostatin receptors in pituitary function, diagnosis and therapy","volume":"32","author":"Hofland LJ","year":"2004","journal-title":"Front Horm Res"},{"issue":"6","key":"ref116","doi-asserted-by":"crossref","first-page":"472","DOI":"10.7326\/0003-4819-129-6-199809150-00009","article-title":"Management of pituitary tumors","volume":"129","author":"Shimon I","year":"1998","journal-title":"Ann Intern Med"},{"issue":"5","key":"ref117","first-page":"1363","article-title":"New technique for quantitation of pituitary adenoma size: use in evaluating treatment of gonadotroph adenomas with a gonadotropin-releasing hormone antagonist","volume":"76","author":"McGrath GA","year":"1993","journal-title":"J Clin Endocrinol 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