{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:31Z","timestamp":1790172571987,"version":"4.1.0"},"reference-count":54,"publisher":"Archives of Endocrinology and Metabolism","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Endocrinol. Metab."],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1590\/2359-3997000000284","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T19:45:42Z","timestamp":1499629542000},"page":"391-397","source":"Crossref","is-referenced-by-count":15,"title":["The use of aromatase inhibitors in boys with short stature: what to know before prescribing?"],"prefix":"10.20945","volume":"61","author":[{"given":"Alessandra","family":"Linardi","sequence":"first","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durval","family":"Damiani","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Longui","sequence":"additional","affiliation":[{"name":"FCMSCSP,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8510","reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1021\/jm058042r","article-title":"Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach","volume":"48","author":"Cavalli A","year":"2005","journal-title":"J Med Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.mce.2006.04.031","article-title":"Use of aromatase inhibitors to increase final height","volume":"254-255","author":"Dunkel L","year":"2006","journal-title":"Mol Cell Endocrinol"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1210\/jcem.82.8.4161","article-title":"Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology","volume":"82","author":"Labrie F","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"23","key":"ref4","doi-asserted-by":"crossref","first-page":"8948","DOI":"10.1073\/pnas.85.23.8948","article-title":"Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells","volume":"85","author":"Corbin CJ","year":"1988","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4274\/jcrpe.v1i6.256","article-title":"Aromatase inhibitors to augment height: continued caution and study required","volume":"1","author":"Geffner ME","year":"2009","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"12","key":"ref6","first-page":"4677","article-title":"Estrogen: consequences and implications of human mutations in synthesis and action","volume":"84","author":"Grumbach MM","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"ref7","first-page":"3689","article-title":"Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens","volume":"80","author":"Morishima A","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1056\/NEJM199707103370204","article-title":"Effect of testosterone and estradiol in a man with aromatase deficiency","volume":"337","author":"Carani C","year":"1997","journal-title":"N Engl J Med"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/MOP.0b013e32833ab888","article-title":"Use of aromatase inhibitors in children and adolescents: what\u2019s new?","volume":"22","author":"Diaz-Thomas A","year":"2010","journal-title":"Curr Opin Pediatr"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1586\/17446651.2014.926810","article-title":"Understanding the pathological manifestations of aromatase excess syndrome: lessons for clinical diagnosis","volume":"9","author":"Shozu M","year":"2014","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1210\/jc.2009-1743","article-title":"Tall stature without growth hormone: four male patients with aromatase deficiency","volume":"95","author":"Rochira V","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"ref12","article-title":"Aromatase inhibitors for short stature in male children and adolescents","author":"Grath N","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1210\/jc.2016-2891","article-title":"Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature","volume":"101","author":"Mauras N","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref14","first-page":"744","article-title":"Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index","volume":"78","author":"Juul A","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.6065\/apem.2015.20.1.8","article-title":"Pubertal growth and epiphyseal fusion","volume":"20","author":"Shim KS","year":"2015","journal-title":"Ann Pediatr Endocrinol Metab"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrendo.2011.161","article-title":"Aromatase inhibitors in pediatrics","author":"Wit JM","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"1-5","key":"ref17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0960-0760(01)00126-1","article-title":"Comparative clinical pharmacology and pharmacokinetic interactions of aromatase inhibitors","volume":"79","author":"Boeddinghaus IM","year":"2001","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.pcl.2011.07.007","article-title":"Strategies for maximizing growth in puberty in children with short stature","volume":"58","author":"Mauras N","year":"2011","journal-title":"Pediatr Clin North Am"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/cncr.10908","article-title":"An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane","volume":"95","author":"Buzdar AU","year":"2002","journal-title":"Cancer"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1210\/jc.2008-2527","article-title":"Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia","volume":"94","author":"Mauras N","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/j.1552-4604.1998.tb04813.x","article-title":"Plasma protein binding of letrozole, a new nonsteroidal aromatase enzyme inhibitor","volume":"38","author":"Colussi DM","year":"1998","journal-title":"J Clin Pharmacol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0009-2797(84)90036-X","article-title":"Interactions of nitrogen heterocycles with cytochrome P-450 and monooxygenase activity","volume":"50","author":"Murray M","year":"1984","journal-title":"Chem Biol Interact"},{"issue":"5","key":"ref23","first-page":"598","article-title":"Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase","volume":"25","author":"Grimm S","year":"1997","journal-title":"Drug Metab Dispos"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1365-2125.2010.03791.x","article-title":"In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole","volume":"70","author":"Kamdem LK","year":"2010","journal-title":"Br J Clin Pharmacol"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1517\/14656566.2012.687721","article-title":"Pharmacogenomics of third-generation aromatase inhibitors","volume":"13","author":"Turkistani A","year":"2012","journal-title":"Expert Opin Pharmacother"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3109\/00498250903171395","article-title":"Deactivation of anticancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes","volume":"39","author":"Murai K","year":"2009","journal-title":"Xenobiotica"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1124\/dmd.113.053405","article-title":"The letrozole phase 1 metabolite carbinol as a novel probe drug for UGT2B7","volume":"41","author":"Precht JC","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/bdd.273","article-title":"Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients","volume":"22","author":"Pfister CU","year":"2001","journal-title":"Biopharm Drug Dispos"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0093-7754(03)00305-1","article-title":"Pharmacokinetics of third-generation aromatase inhibitors","volume":"30","author":"L\u00f8nning P","year":"2003","journal-title":"Semin Oncol"},{"issue":"1-3","key":"ref30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2005.10.020","article-title":"Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS\/MS method for the analysis of estradiol product formation","volume":"219","author":"Tr\u00f6sken ER","year":"2006","journal-title":"Toxicology"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2174\/1389200215666141125121511","article-title":"Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450","volume":"15","author":"Niwa T","year":"2014","journal-title":"Curr Drug Metab"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tiv.2007.09.004","article-title":"Inhibition of human aromatase complex (CYP19) by antiepileptic drugs","volume":"22","author":"Jacobsen NW","year":"2008","journal-title":"Toxicol In Vitro"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.tox.2004.08.005","article-title":"Marijuana extracts possess the effects like the endocrine disrupting chemicals","volume":"206","author":"Watanabe K","year":"2005","journal-title":"Toxicology"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.nut.2009.01.001","article-title":"Red wine increases adipose tissue aromatase expression and regulates body weight and adipocyte size","volume":"25","author":"Monteiro R","year":"2009","journal-title":"Nutrition"},{"issue":"1-2","key":"ref35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jsbmb.2008.02.013","article-title":"Red wine interferes with oestrogen signalling in rat hippocampus","volume":"111","author":"Monteiro R","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"ref36","first-page":"149","article-title":"Ethanol stimulates proliferation, ERalpha and aromatase expression in MCF-7 human breast cancer cells","volume":"13","author":"Etique N","year":"2004","journal-title":"Int J Mol Med"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/jwh.2011.3001","article-title":"Red versus white wine as a nutritional aromatase inhibitor in premenopausal women: a pilot study","volume":"21","author":"Shufelt C","year":"2012","journal-title":"Womens Health (Larchmt)"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/clpt.2011.174","article-title":"Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age","volume":"90","author":"Desta Z","year":"2011","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1081\/DMR-120015696","article-title":"Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6","volume":"34","author":"Nakajima M","year":"2002","journal-title":"Drug Metab Rev"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mcp.2000.104391","article-title":"CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity","volume":"67","author":"Sata F","year":"2000","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/hep.20131","article-title":"Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4","volume":"39","author":"Ehmer U","year":"2004","journal-title":"Hepatology"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1389200053586064","article-title":"Polymorphism of UDP-glucuronosyltransferase and drug metabolism","volume":"6","author":"Maruo Y","year":"2005","journal-title":"Curr Drug Metab"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2133\/dmpk.20.227","article-title":"Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation","volume":"2","author":"Nakajima M","year":"2005","journal-title":"Drug Metab Pharmacokinet"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1124\/dmd.112.048157","article-title":"Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics","volume":"41","author":"Edavana VK","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2125.2001.01358.x","article-title":"The effect of anastrozole on the single-dose pharmacokinetics and anticoagulant activity of warfarin in healthy volunteers","volume":"51","author":"Yates RA","year":"2001","journal-title":"Br J Clin Pharmacol"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1054\/bjoc.2001.1925","article-title":"Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the \u2018Arimidex and tamoxifen alone or in combination\u2019 (ATAC) trial","volume":"85","author":"Dowsett M","year":"2001","journal-title":"Br J Cancer"},{"issue":"9","key":"ref47","first-page":"2338","article-title":"Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer","volume":"5","author":"Dowsett M","year":"1999","journal-title":"Clin Cancer Res"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00280-009-0935-7","article-title":"Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4\u2019-methanol-bisbenzonitrile in vitro","volume":"64","author":"Jeong S","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.cnur.2013.09.004","article-title":"Cytochrome p450 Part 3: drug interactions","volume":"48","author":"Krau SD","year":"2013","journal-title":"Nurs Clin N Am"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger UM","year":"2013","journal-title":"Pharmacol Ther"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1586\/17512433.2014.910111","article-title":"Understanding and preventing drug-drug and drug-gene interactions","volume":"7","author":"Tannenbaum C","year":"2014","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2174\/138920009789895507","article-title":"Structure, function, regulation and polymorphism of human cytochrome P450 2A6","volume":"10","author":"Di YM","year":"2009","journal-title":"Curr Drug Metab"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.bcp.2003.10.022","article-title":"Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6","volume":"67","author":"Denton TT","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2125.2009.03568.x","article-title":"Effects of nicotine on cytochrome P450 2A6 and 2E1 activities","volume":"69","author":"Hukkanen J","year":"2010","journal-title":"Br J Clin Pharmacol"}],"container-title":["Archives of Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/aem\/v61n4\/0004-2730-aem-61-4-0391.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T16:20:17Z","timestamp":1527697217000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S2359-39972017000400391&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S2359-39972017000400391"],"URL":"https:\/\/doi.org\/10.1590\/2359-3997000000284","relation":{},"ISSN":["2359-3997"],"issn-type":[{"value":"2359-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}