{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:56:10Z","timestamp":1774353370641,"version":"3.50.1"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH. Specific antibodies such as antiendomysium, antireticulina, antigliadin and, recently identified, the epidermal and tissue transglutaminase subtypes, as well as increased zonulin production, are common to both conditions, along with gluten-sensitive enteropathy and DH. Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease. The chosen treatment is dapsone and a gluten-free diet.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20131775","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T22:00:20Z","timestamp":1380751220000},"page":"594-599","source":"Crossref","is-referenced-by-count":51,"title":["Review: dermatitis herpetiformis"],"prefix":"10.1590","volume":"88","author":[{"given":"Fernanda Berti Rocha","family":"Mendes","sequence":"first","affiliation":[{"name":"University of Oeste Paulista, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adaucto","family":"Hissa-Elian","sequence":"additional","affiliation":[{"name":"University of Serra dos \u00d3rg\u00e3os, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilda Aparecida Milanez Morgado de","family":"Abreu","sequence":"additional","affiliation":[{"name":"University of Oeste Paulista"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00ednica Scaff","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"University of Oeste Paulista, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Lever's Histopathology of the Skin","first-page":"209","volume-title":"Noninfectious Vesiculobullous and Vesiculopustular Diseases","author":"Cohen LM","year":"1997","edition":"8"},{"key":"ref2","series-title":"Dermatology in General Medicine","first-page":"500","volume-title":"Dermatitis Herpetiformis","author":"Katz SI","year":"2010","edition":"7"},{"key":"ref3","series-title":"Dermatologia","first-page":"128","volume-title":"Buloses","author":"Azulay-Abulafia L","year":"2006","edition":"4"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1242\/jcs.02888","article-title":"The desmosome: cell science lessons from human diseases","volume":"119","author":"Kottke MD","year":"2006","journal-title":"J Cell Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/03008200600584157","article-title":"Epidermal basement membrane: its molecular organization and blistering disorders","volume":"47","author":"Masunaga R","year":"2006","journal-title":"Connect Tissue Res"},{"key":"ref6","series-title":"Dermatologia","first-page":"301","volume-title":"Erup\u00e7\u00f5es v\u00e9sico-bolhosas","author":"Sampaio SAP","year":"2008","edition":"3"},{"key":"ref7","first-page":"523","article-title":"Dermatitis Herpetiformis: problems, progress and prospects","volume":"12","author":"Lionel FRY","year":"2002","journal-title":"Eur J Dermatol"},{"key":"ref8","series-title":"Atlas de dermatologia cl\u00ednica","first-page":"421","volume-title":"Dist\u00farbios bolhosos da pele","author":"du Vivier A","year":"2004","edition":"3"},{"key":"ref9","series-title":"Textbook of Dermatology","first-page":"1817","volume-title":"Bullous eruptions","author":"Wojnarouska F","year":"1998","edition":"6"},{"key":"ref10","first-page":"8","article-title":"Dermatitis herpetiformis","volume":"9","author":"Kosan MK","year":"2003","journal-title":"Dermatol Online J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1440-1754.2005.00614.x","article-title":"Coeliac disease presenting as dermatitis herpetiformis in infancy","volume":"41","author":"Lemberg D","year":"2005","journal-title":"J Paediatr Child Health"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1525-1470.2002.00096.x","article-title":"Dermatitis herpetiformes: should direct immunofluorescence be the only diagnostic criterion?","volume":"19","author":"Lourdes S","year":"2002","journal-title":"Pediatr Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-4632.2007.03214.x","article-title":"Clinical, pathologic and immunopathologic features of dermatitis herpetiformes: review of the Mayo Clicic experience","volume":"46","author":"Alonso-Llamazares J","year":"2007","journal-title":"Int J Dermatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1610-0387.2009.07292_supp.x","article-title":"Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis Duhring","volume":"8","author":"Rose C","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1468-3083.2009.03188.x","article-title":"Guidelines for the diagnosis and treatment of dermatitis herpetiformis","volume":"23","author":"Caproni M","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI200421055","article-title":"A New Model for Dermatitis Herpetiformis that uses HLA-DQ8 transgenic NOD mice. 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