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He was treated for seven months with numerous treatments, including immunosuppressive drugs, with an unsatisfactory response, until he had complete remission with the use of rituximab. During a 34-month follow-up period, the patient presented a slight clinical relapse, which was successfully controlled with prednisone in a daily dose of 120mg, soon reduced to 20mg.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20131990","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T21:59:30Z","timestamp":1380751170000},"page":"639-642","source":"Crossref","is-referenced-by-count":10,"title":["Severe Multi-Resistant Pemphigus vulgaris: prolonged remission with a single cycle of Rituximab"],"prefix":"10.1590","volume":"88","author":[{"given":"Isabela Soubhia","family":"Corral","sequence":"first","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Helena Proen\u00e7a de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Telles Rudge de","family":"Aquino","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Abbruzzini S.","family":"Koller","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisa Ruffolo","family":"Magliari","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo (FCMSCMSP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Muller","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1610-0387.2007.06602.x","article-title":"Recommendations for the use of rituximab (anti-CD20 antibody) in the treatment of autoimmune bullous skin diseases","volume":"6","author":"Hertl M","year":"2008","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1046\/j.1365-2133.2003.05580.x","article-title":"Rapid response of treatment-resistant pemphigus foliaceus to the anti-CD20 antibody rituximab","volume":"149","author":"Goebeler M","year":"2003","journal-title":"Br J Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.det.2011.06.023","article-title":"Rituximab and its use in autoimmune bullous disorders","volume":"29","author":"Daniel BS","year":"2011","journal-title":"Dermatol Clin"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00296-007-0471-x","article-title":"The potential utility of B cell-directed biologic therapy in autoimmune diseases","volume":"28","author":"Arkfeld DG","year":"2008","journal-title":"Rheumatol Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1038\/jid.2008.178","article-title":"B-cell depletion immunotherapy in pemphigus: effects on cellular and humoral immune responses","volume":"128","author":"Mouquet H","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/archderm.143.8.1033","article-title":"Treatment of Severe Pemphigus with Rituximab: report of 12 cases and a review of the literature","volume":"143","author":"Cianchini G","year":"2007","journal-title":"Arch Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1001\/archdermatol.2011.3320","article-title":"Effect of a single-cycle alternative dosing regimen for rituximab for recalcitrant pemphigus: a case series of 9 patients","volume":"148","author":"Matsukura S","year":"2012","journal-title":"Arch Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJMoa067752","article-title":"A single cycle of rituximab for the treatment of severe pemphigus","volume":"357","author":"Joly P","year":"2007","journal-title":"N Engl J Med"},{"key":"ref9","first-page":"545","article-title":"Rituximab and pemphigus - 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