{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:17:28Z","timestamp":1791317848636,"version":"4.3.1"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>This study shows the effectiveness of photodynamic therapy based on methylene blue dye for the treatment of endonyx toenail onychomycosis. Four patients with endonyx onychomycosis caused by Trichophyton rubrum were treated with 2% methylene blue aqueous solution irradiated with light emission diode at 630 nm and an energy density of 36 J\/cm2 for 6 months at 2-week intervals. The preliminary study showed the effectiveness of this therapy in the treatment of endonyx onychomycosis, and also indicated that the disease can be caused by T. rubrum.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20132180","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T14:05:22Z","timestamp":1392386722000},"page":"1019-1021","source":"Crossref","is-referenced-by-count":19,"title":["Endonyx toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye"],"prefix":"10.1590","volume":"88","author":[{"given":"Linton Wallis Figueiredo","family":"Souza","sequence":"first","affiliation":[{"name":"Montes Claros State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Vilas Trancoso","family":"Souza","sequence":"additional","affiliation":[{"name":"Montes Claros State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina de Carvalho","family":"Botelho","sequence":"additional","affiliation":[{"name":"Montes Claros State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Baran&Dawber Disease of the nails and their management","author":"Baran R","year":"2012","edition":"4th ed"},{"key":"ref2","first-page":"52","article-title":"\"Endonyx\" Onychomycosis: A New Modality of Nail Invasion by Dermatophytes","volume":"79","author":"Tosti A","year":"1999","journal-title":"ActaDermVenereol"},{"key":"ref3","first-page":"175","article-title":"Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications","volume":"2","author":"Tardivo JP","year":"2005","journal-title":"PhotodiagnPhotodynTher"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.1365-2133.2003.05091.x","article-title":"Antimicrobial photodynamic therapy: assessment of genotoxic effects on keratinocytes in vitro","volume":"148","author":"Zeina B","year":"2003","journal-title":"Br J Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/pho.2012.3225","article-title":"Antimicrobial photodynamic therapy in the treatment of oral candidiasis in HIV-infected patients","volume":"30","author":"Scwingel AR","year":"2012","journal-title":"Photomed Laser Surg"},{"key":"ref6","series-title":"Fundamental medical mycology","author":"Reiss E","year":"2011"},{"key":"ref7","series-title":"Handbook of Dermatology","author":"Mann MW","year":"2009"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1590\/S0365-05962012000200009","article-title":"Phototoxic action of light emitting diode in the in vitro viability of Trichophyton rubrum","volume":"87","author":"Amorim JC","year":"2012","journal-title":"An Bras Dermatol"},{"key":"ref9","first-page":"2","article-title":"The susceptibility of dermatophytes to photodynamic treatment with special focus on Trichophyton rubrum","volume":"87","author":"Smijs TG","year":"2011","journal-title":"PhotochemPhotobiol"},{"key":"ref10","first-page":"216","article-title":"Photodynamic therapy for distal and lateral subungual toenail onychomycosis caused by Trichophyton rubrum: Preliminary results of a single-centre open trial","volume":"90","author":"Sotiriou E","year":"2010","journal-title":"ActaDermVenereol"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v88n6\/0365-0596-abd-88-06-1019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:41Z","timestamp":1747666841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962013000601019&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0365-05962013000601019"],"URL":"https:\/\/doi.org\/10.1590\/abd1806-4841.20132180","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}