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The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20132187","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T19:46:54Z","timestamp":1391111214000},"page":"23-25","source":"Crossref","is-referenced-by-count":9,"title":["Biological agents: investigation into leprosy and other infectious diseases before indication"],"prefix":"10.1590","volume":"88","author":[{"given":"Jo\u00e3o Roberto","family":"Ant\u00f4nio","sequence":"first","affiliation":[{"name":"State Medical School of S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Maria Cordeiro","family":"Soubhia","sequence":"additional","affiliation":[{"name":"State Medical School of S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania Del Arco","family":"Paschoal","sequence":"additional","affiliation":[{"name":"State Medical School of S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Forte","family":"Amarante","sequence":"additional","affiliation":[{"name":"Regional Medical School Foundation, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Regina Franchi","family":"Travolo","sequence":"additional","affiliation":[{"name":"Regional Medical School Foundation, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1590\/S0482-50042012000200002","article-title":"Consenso 2012 da Sociedade Brasileira de Reumatologia para o tratamento da artrite reumatoide","volume":"52","year":"2012","journal-title":"Rev Bras Reumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/383317","article-title":"Granulomatous infectious diseases associated with tumor necrosis factor antagonists","volume":"38","author":"Wallis RS","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ncprheum0336","article-title":"Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor","volume":"2","author":"Winthrop KL","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1590\/S0482-50042010000300013","article-title":"Hansen\u00edase virchowiana associada ao uso de inibidor do fator de necrose tumoral alfa","volume":"50","author":"Freitas DS","year":"2010","journal-title":"Rev Bras Reumatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5433\/1679-0367.2011v32n1p77","article-title":"A Terapia Anti-TNF-? na Artrite Reumat\u00f3ide","volume":"32","author":"Faleiro LR","year":"2011","journal-title":"Semina Cienc Biol Saude"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/art.23815","article-title":"Type I reaction of Hansen's disease with exposure to Adalimumabe: A case report","volume":"59","author":"Oberstein EM","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1128\/IAI.67.1.423-425.1999","article-title":"Soluble tumor necrosis factor alpha receptors in Sera from Leprosy patients","volume":"67","author":"Munk ME","year":"1999","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1086\/505222","article-title":"Development of Leprosy and type 1 reactions after treatment with Infliximab: A report of 2 cases","volume":"43","author":"Scollard DM","year":"2006","journal-title":"Clin Infect Dis"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v88n6s1\/0365-0596-abd-88-06-s1-0023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:41Z","timestamp":1747666841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962013000800023&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":8,"journal-issue":{"issue":"6 suppl 1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0365-05962013000800023"],"URL":"https:\/\/doi.org\/10.1590\/abd1806-4841.20132187","relation":{},"ISSN":["0365-0596"],"issn-type":[{"type":"electronic","value":"0365-0596"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}