{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:42:44Z","timestamp":1790404964375,"version":"4.1.0"},"reference-count":125,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Giant congenital melanocytic nevus is usually defined as a melanocytic lesion present at birth that will reach a diameter \u2265 20 cm in adulthood. Its incidence is estimated in &lt;1:20,000 newborns. Despite its rarity, this lesion is important because it may associate with severe complications such as malignant melanoma, affect the central nervous system (neurocutaneous melanosis), and have major psychosocial impact on the patient and his family due to its unsightly appearance. Giant congenital melanocytic nevus generally presents as a brown lesion, with flat or mammilated surface, well-demarcated borders and hypertrichosis. Congenital melanocytic nevus is primarily a clinical diagnosis. However, congenital nevi are histologically distinguished from acquired nevi mainly by their larger size, the spread of the nevus cells to the deep layers of the skin and by their more varied architecture and morphology. Although giant congenital melanocytic nevus is recognized as a risk factor for the development of melanoma, the precise magnitude of this risk is still controversial. The estimated lifetime risk of developing melanoma varies from 5 to 10%. On account of these uncertainties and the size of the lesions, the management of giant congenital melanocytic nevus needs individualization. Treatment may include surgical and non-surgical procedures, psychological intervention and\/or clinical follow-up, with special attention to changes in color, texture or on the surface of the lesion. The only absolute indication for surgery in giant congenital melanocytic nevus is the development of a malignant neoplasm on the lesion.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20132233","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T14:05:26Z","timestamp":1392386726000},"page":"863-878","source":"Crossref","is-referenced-by-count":115,"title":["Giant congenital melanocytic nevus"],"prefix":"10.1590","volume":"88","author":[{"given":"Ana Carolina Leite","family":"Viana","sequence":"first","affiliation":[{"name":"Minas Gerais Federal University, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Gontijo","sequence":"additional","affiliation":[{"name":"Minas Gerais Federal University, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Vasques","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Minas Gerais Federal University, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Fitzpatrick's Dermatology in General Medicine","first-page":"1099","volume-title":"Benign neoplasias and hyperplasias of melanocytes","author":"Grichnik JM","year":"2008","edition":"7th ed"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1542\/peds.104.S5.1042","article-title":"The physiology of pigmented nevi","volume":"104","author":"Kincannon J","year":"1999","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0025-7125(16)30966-X","article-title":"Melanocytic precursors of cutaneous melanoma. Estimated risks and guidelines for management","volume":"70","author":"Rhodes AR","year":"1986","journal-title":"Med Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"26e","DOI":"10.1097\/01.prs.0000267583.63342.0a","article-title":"Giant congenital melanocytic nevi","volume":"120","author":"Arneja J","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00006534-197404000-00007","article-title":"The risk of malignancy in large congenital nevi","volume":"53","author":"Kaplan EN","year":"1974","journal-title":"Plast Reconstr Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1440-0960.2009.00553_1.x","article-title":"Congenital melanocytic naevi","volume":"50","author":"Kovalyshyn I","year":"2009","journal-title":"Australas J Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0733-8635(02)00030-X","article-title":"Congenital melanocytic nevi. Evaluation and management","volume":"20","author":"Marghoob AA","year":"2002","journal-title":"Dermatol Clin"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1365-2133.1998.02385.x","article-title":"Dormant melanocytes in the dermis: do dermal melanocytes of acquired dermal melanocytosis exist from birth?","volume":"139","author":"Mizushima J","year":"1998","journal-title":"Br J Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1001\/archderm.1986.01660230049009","article-title":"Congenital nevomelanocytic nevi. Histologic patterns in the first year of life and evolution during childhood","volume":"122","author":"Rhodes AR","year":"1986","journal-title":"Arch Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/DAD.0b013e3181fb5bc7","article-title":"Lack of BRAF(V600E) mutations in giant congenital melanocytic nevi in a Chinese population","volume":"33","author":"Wu D","year":"2011","journal-title":"Am J Dermatopathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.sder.2010.04.007","article-title":"Large congenital melanocytic nevi: associated risks and management considerations","volume":"29","author":"Slutsky JB","year":"2010","journal-title":"Semin Cutan Med Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2133.2008.08849.x","article-title":"Great Ormond Street Hospital for Children Registry for congenital melanocytic naevi: prospective study 1988-2007. Part 1epidemiology, phenotype and outcomes","volume":"160","author":"Kinsler VA","year":"2009","journal-title":"Br J Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1e","DOI":"10.1097\/PRS.0b013e3181ab11be","article-title":"Giant congenital melanocytic nevi","volume":"124","author":"Arneja J","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jaad.2006.05.076","article-title":"Spontaneous involution of congenital melanocytic nevi of the scalp","volume":"58","author":"Strauss RM","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2133.2006.07218.x","article-title":"Melanoma risk in congenital melanocytic naevi: a systematic review","volume":"155","author":"Krengel S","year":"2006","journal-title":"Br J Dermatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1365-2133.2005.06316.x","article-title":"Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi--results from the NYU-LCMN registry","volume":"152","author":"Hale E","year":"2005","journal-title":"Br J Dermatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaad.2004.07.020","article-title":"Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management","volume":"52","author":"Tannous Z","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1097\/01.PRS.0000122209.10277.2A","article-title":"Risk of melanoma arising in large congenital melanocytic nevi: a systematic review","volume":"113","author":"Watt AJ","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1542\/peds.106.4.736","article-title":"Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis","volume":"106","author":"Bittencourt F","year":"2000","journal-title":"Pediatrics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0190-9622(79)70009-0","article-title":"Congenital nevocytic nevi and malignant melanomas","volume":"1","author":"Kopf A","year":"1979","journal-title":"J Am Acad Dermatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S1040-0486(00)90039-5","article-title":"Large congenital melanocytic nevi","volume":"12","author":"Marghoob AA","year":"2000","journal-title":"Curr Probl Dermatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1046\/j.1365-2230.2000.00712.x","article-title":"Psychosocial sequelae in 29 children with giant congenital melanocytic naevi","volume":"25","author":"Koot HM","year":"2000","journal-title":"Clin Exp Dermatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.sder.2008.03.007","article-title":"Congenital melanocytic nevi: treatment modalities and management options","volume":"26","author":"Marghoob AA","year":"2007","journal-title":"Semin Cutan Med Surg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0190-9622(98)70264-6","article-title":"Cutaneous melanoma risk and phenotypic changes in large congenital nevi: a follow-up study of 46 patients","volume":"39","author":"Egan CL","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0190-9622(95)90343-7","article-title":"The risk of melanoma in patients with congenital nevi: a cohort study","volume":"32","author":"Swerdlow AJ","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00006534-196507000-00006","article-title":"Incidence of malignancy in giant pigmented nevi","volume":"36","author":"Greeley PW","year":"1965","journal-title":"Plast Reconstr Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0022-3476(05)81958-4","article-title":"Giant pigmented nevi: clinical, histopathologic, and therapeutic considerations","volume":"120","author":"Ruiz-Maldonado R","year":"1992","journal-title":"J Pediatr"},{"key":"ref28","first-page":"174","article-title":"The incidence of malignant melanoma (0 to 15 years of age) arising in \"large\" congenital nevocellular nevi","volume":"78","author":"Quaba AA","year":"1986","journal-title":"Plast Reconstr Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00008390-200502000-00010","article-title":"The association between large congenital melanocytic naevi and cutaneous melanoma: preliminary findings from an Internet-based registry of 379 patients","volume":"15","author":"Ka VS","year":"2005","journal-title":"Melanoma Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bjps.2004.04.022","article-title":"Classification of congenital melanocytic naevi and malignant transformation: a review of the literature","volume":"57","author":"Zaal L","year":"2004","journal-title":"Br J Plast Surg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1365-2133.1976.tb00840.x","article-title":"Pigmented lesions in newborn infants","volume":"95","author":"Walton RG","year":"1976","journal-title":"Br J Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2133.1981.tb00954.x","article-title":"Epidemiology of congenital pigmented naevi: I. Incidence rates and relative frequencies","volume":"104","author":"Castilla EE","year":"1981","journal-title":"Br J Dermatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jaad.2005.02.024","article-title":"Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons","volume":"52","author":"Bett B","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1067\/mjd.2001.112403","article-title":"Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis","volume":"44","author":"Takayama H","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00000372-200608000-00020","article-title":"Histogenesis of congenital and acquired melanocytic nevi: a unifying concept","volume":"28","author":"Saida T","year":"2006","journal-title":"Am J Dermatopathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1046\/j.1365-2133.1999.03197.x","article-title":"Lack of clinical-pathological correlation in the diagnosis of congenital naevi","volume":"141","author":"Cribier BJ","year":"1999","journal-title":"Br J Dermatol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0190-9622(84)70181-2","article-title":"Histologic patterns of congenital nevocytic nevi and implications for treatment","volume":"11","author":"Zitelli JA","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1073\/pnas.94.2.701","article-title":"Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor\/scatter factor","volume":"94","author":"Takayama H","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1073\/pnas.93.12.5866","article-title":"Scatter factor\/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development","volume":"93","author":"Takayama H","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1242\/dev.00213","article-title":"Molecular identification of distinct neurogenic and melanogenic neural crest sublineages","volume":"130","author":"Luo R","year":"2003","journal-title":"Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/01.pas.0000126785.61609.6e","article-title":"Proliferative nodules in congenital melanocytic nevi: a clinicopathologic and immunohistochemical analysis","volume":"28","author":"Herron MD","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/02844319309078115","article-title":"Treatment of large congenital naevi.A review and report of six cases","volume":"27","author":"Sandsmark M","year":"1993","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0046-8177(73)80101-7","article-title":"Congenital melanocytic nevi of the small and garment type. Clinical, histologic, and ultrastructural studies","volume":"4","author":"Mark GJ","year":"1973","journal-title":"Hum Pathol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-2133.1996.tb06959.x","article-title":"A prospective study of congenital melanocytic naevi: progress report and evaluation after 6 years","volume":"134","author":"Dawson HA","year":"1996","journal-title":"Br J Dermatol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1525-1470.1992.tb00624.x","article-title":"Congenital nevi--let's be practical","volume":"9","author":"From L","year":"1992","journal-title":"Pediatr Dermatol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1542\/peds.55.2.191","article-title":"Metastatic malignant melanoma in prepubertal children","volume":"55","author":"Trozak DJ","year":"1975","journal-title":"Pediatrics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.scs.0000183356.41637.f5","article-title":"Giant congenital melanocytic nevi of the trunk and an algorithm for treatment","volume":"16","author":"Arneja JS","year":"2005","journal-title":"J Craniofac Surg"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0190-9622(97)80217-4","article-title":"A study of large congenital melanocytic nevi and associated malignant melanomas: review of cases in the New York University Registry and the world literature","volume":"36","author":"DeDavid M","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/archderm.1996.03890260072011","article-title":"Large congenital melanocytic nevi and the risk for the development of malignant melanoma","volume":"132","author":"Marghoob AA","year":"1996","journal-title":"A prospective study.Arch Dermatol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1111\/j.1524-4725.2010.01641.x","article-title":"Comparison of classification systems for congenital melanocytic nevi","volume":"36","author":"Turkmen A","year":"2010","journal-title":"Dermatol Surg"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1001\/archderm.1965.01600080008002","article-title":"Giant pigmented nevi, melanoma, and leptomeningeal melanocytosis: a clinical and histopathological study","volume":"91","author":"Reed WB","year":"1965","journal-title":"Arch Dermatol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.jaad.2004.12.040","article-title":"Life-threatening blood loss from scratching provoked by pruritus in the bulky perineal nevocytoma variant of giant congenital melanocytic nevus in a child","volume":"53","author":"Feng J","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1525-1470.1999.00092.x","article-title":"Neonatal erosions and ulcerations in giant congenital melanocytic nevi","volume":"16","author":"Giam YC","year":"1999","journal-title":"Pediatr Dermatol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clindermatol.2010.04.004","article-title":"Congenital melanocytic nevi-when to worry and how to treat: Facts and controversies","volume":"28","author":"Price H","year":"2010","journal-title":"Clin Dermatol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.sder.2010.06.007","article-title":"The risk of melanoma and neurocutaneous melanosis associated with congenital melanocytic nevi","volume":"29","author":"Shah KN","year":"2010","journal-title":"Semin Cutan Med Surg"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.sder.2004.01.007","article-title":"Neurocutaneous melanosis","volume":"23","author":"Makkar HS","year":"2004","journal-title":"Semin Cutan Med Surg"},{"key":"ref57","first-page":"S265","article-title":"Neurocutaneous melanosis","volume":"25","author":"Mart\u00ednez-Granero MA","year":"1997","journal-title":"Rev Neurol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0190-9622(91)70115-I","article-title":"Neurocutaneous melanosis: definition and review of the literature","volume":"24","author":"Kadonaga JN","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0190-9622(94)70204-7","article-title":"Giant congenital melanocytic nevi: brain magnetic resonance findings in neurologically asymptomatic children","volume":"31","author":"Frieden IJ","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/01.scs.0000231619.95263.a2","article-title":"Giant nevi: a review","volume":"17","author":"Chung C","year":"2006","journal-title":"J Craniofac Surg"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1525-1470.2000.017005387.x","article-title":"Giant congenital melanocytic nevus with underlying hypoplasia of the subcutaneous fat","volume":"17","author":"Caradona SA","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/088307380201700410","article-title":"Giant congenital melanocytic nevi in a patient with brain structural malformations and multiple lipomatosis","volume":"17","author":"Wieselthaler NA","year":"2002","journal-title":"J Child Neurol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1525-1470.1998.1998015287.x","article-title":"Lower and upper extremity atrophy associated with a giant congenital melanocytic nevus","volume":"15","author":"Itin PH","year":"1998","journal-title":"Pediatr Dermatol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jaad.2008.11.022","article-title":"Large congenital melanocytic nevi and neurocutaneous melanocytosis: one pediatric center's experience","volume":"61","author":"Lovett A","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1525-1470.2002.00028.x","article-title":"Acquired leukoderma in congenital pigmented nevus associated with vitiligo-like depigmentation","volume":"19","author":"Itin PH","year":"2002","journal-title":"Pediatr Dermatol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00006534-200104010-00005","article-title":"Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children","volume":"107","author":"Foster RD","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.0736-8046.2004.21222.x","article-title":"Measuring congenital melanocytic nevi","volume":"21","author":"Ruiz-Maldonado R","year":"2004","journal-title":"Pediatr Dermatol. 2004"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00006534-197607000-00008","article-title":"Congenital giant nevi: clinical and pathological considerations","volume":"58","author":"Lanier VC","year":"1976","journal-title":"Plast Reconstr Surg"},{"key":"ref69","first-page":"613","article-title":"Naevus pigmentosus giganticus: indikationer for operative Behandling","volume":"125","author":"Pers M","year":"1963","journal-title":"Ugeskr Laeger"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1001\/archderm.1985.01660100054014","article-title":"Congenital nevi less than or equal to 10 cm as precursors to melanoma. 52 cases, a review, and a new conception","volume":"121","author":"Illig L","year":"1985","journal-title":"Arch Dermatol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/02844317709025513","article-title":"The incidence of malignant transformation in giant pigmented nevi","volume":"11","author":"Lorentzen M","year":"1977","journal-title":"Scand J Plast Reconstr Surg"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00006534-198106000-00012","article-title":"Nonepidermal origin of malignant melanoma associated with a giant congenital nevocellular nevus","volume":"67","author":"Rhodes AR","year":"1981","journal-title":"Plast Reconstr Surg"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00006534-198309000-00019","article-title":"Congenital nevocellular nevus: a review of the treatment controversy and a report of 46 cases","volume":"72","author":"Arons MS","year":"1983","journal-title":"Plast Reconstr Surg"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/archderm.1980.01640270078020","article-title":"Giant congenital neuroid melanocytic nevus","volume":"116","author":"Solomon L","year":"1980","journal-title":"Arch Dermatol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/00006534-198812000-00012","article-title":"An approach to excision of congenital giant pigmented nevi in infancy and early childhood","volume":"82","author":"Bauer BS","year":"1988","journal-title":"Plast Reconstr Surg"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0190-9622(96)90834-8","article-title":"Congenital nevomelanocytic nevi: proportionate area expansion during infancy and early childhood","volume":"34","author":"Rhodes AR","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archderm.1987.01660300025002","article-title":"Congenital nevi: accuracy of relative area index measurements","volume":"123","author":"Enhamre A","year":"1987","journal-title":"Arch Dermatol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0190-9622(96)90674-X","article-title":"Neurocutaneous melanosis: clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis","volume":"35","author":"DeDavid M","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1001\/archderm.1986.01660170025003","article-title":"Relative area index in congenital nevi","volume":"122","author":"Enhamre A","year":"1986","journal-title":"Arch Dermatol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/DAD.0b013e3181c6afce","article-title":"Angiotropic neonatal congenital melanocytic nevus: how extravascular migration of melanocytes may explain the development of congenital nevi","volume":"32","author":"Barnhill RL","year":"2010","journal-title":"Am J Dermatopathol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1097\/01.prs.0000189205.85968.12","article-title":"Risk of malignant transformation of congenital melanocytic nevi: a retrospective nationwide study from The Netherlands","volume":"116","author":"Zaal LH","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/archderm.1985.01660100046013","article-title":"A histologic comparison of congenital and acquired nevomelanocytic nevi","volume":"121","author":"Rhodes AR","year":"1985","journal-title":"Arch Dermatol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/0190-9622(95)91816-7","article-title":"Histologic features of congenital melanocytic nevi in infants 1 year of age or younger","volume":"33","author":"Barnhill RL","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00000372-198902000-00002","article-title":"Histopathology of congenital pigmented nevi","volume":"11","author":"Everett MA","year":"1989","journal-title":"Am J Dermatopathol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1097\/00006534-200210000-00031","article-title":"Congenital giant hairy nevi and neurofibromatosis: the significance of their common origin","volume":"110","author":"Silfen R","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/archderm.143.8.1007","article-title":"Age-and site-specific variation in the dermoscopic patterns of congenital melanocytic nevi: an aid to accurate classification and assessment of melanocytic nevi","volume":"143","author":"Changchien L","year":"2007","journal-title":"Arch Dermatol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neurad.2007.06.009","article-title":"Neurocutaneous melanosis in a newborn with giant congenital melanocytic nevus","volume":"34","author":"D'Argenio A","year":"2007","journal-title":"J Neuroradiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jaad.2005.10.040","article-title":"Large or multiple congenital melanocytic nevi: occurrence of neurocutaneous melanocytosis in 1008 persons","volume":"54","author":"Bett B","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1525-1470.2006.00311.x","article-title":"Clinical resolution of a neonatally eroded giant congenital melanocytic nevus","volume":"23","author":"Gass JK","year":"2006","journal-title":"Pediatr Dermatol"},{"key":"ref90","first-page":"347","article-title":"Nevus giganticus pigmentosus with malignant transformation","volume":"49","author":"Pack GT","year":"1961","journal-title":"Surgery"},{"key":"ref91","series-title":"Risco de desenvolvimento de melanoma em pacientes portadores de nevo melanoc\u00edtico cong\u00eanito gigante [disserta\u00e7\u00e3o] (Risk of development of melanoma in patients with giant congenital melanocytic nevus [dissertation])","author":"Viana ACL","year":"2012"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/PAS.0b013e31821375ea","article-title":"Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases","volume":"35","author":"Phadke PA","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1046\/j.1365-2230.2000.00560.x","article-title":"Treatment options for giant congenital naevi","volume":"25","author":"Lawrence CM","year":"2000","journal-title":"Clin Exp Dermatol"},{"key":"ref94","first-page":"563","article-title":"Large congenital melanocytic nevi and the risk for the development of malignant melanoma: a prospective study","volume":"104","author":"Marghoob AA","year":"1995","journal-title":"J Invest Dermatol"},{"key":"ref95","first-page":"185","article-title":"Recent data on the risk of malignancy in congenital melanocytic nevi: the continuing debate on treatment","volume":"99","author":"Hern\u00e1ndez A","year":"2008","journal-title":"Actas Dermosifiliogr"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00008390-200310000-00002","article-title":"Congenital melanocytic naevi and cutaneous melanoma","volume":"13","author":"Berg P","year":"2003","journal-title":"Melanoma Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bjps.2008.12.016","article-title":"The role of surgery in the management of congenital melanocytic naevi in children: a perspective from Great Ormond Street Hospital","volume":"62","author":"Kinsler V","year":"2009","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/jid.2008.203","article-title":"Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis","volume":"129","author":"Dessars B","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/jcp.2003.014274","article-title":"Gene expression profiles of giant hairy naevi","volume":"57","author":"Dasu MR","year":"2004","journal-title":"J Clin Pathol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0002-9440(10)64393-3","article-title":"Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas","volume":"161","author":"Bastian BC","year":"2002","journal-title":"Am J Pathol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00000478-198103000-00004","article-title":"Neoplasms arising in congenital giant nevi: morphologic study of seven cases and a review of the literature","volume":"5","author":"Hendrickson MR","year":"1981","journal-title":"Am J Surg Pathol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/j.jaad.2006.07.033","article-title":"Schwannoma coexisting with giant congenital melanocytic nevus: is it coincidence?","volume":"56","author":"Bae JM","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1529-8019.2005.05012.x","article-title":"Congenital melanocytic nevi needing treatment","volume":"18","author":"Tromberg J","year":"2005","journal-title":"Dermatol Ther"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jaad.2005.07.046","article-title":"Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: a study of cases from an Internet-based registry","volume":"53","author":"Agero AL","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1365-2133.2008.08775.x","article-title":"Complications of congenital melanocytic naevi in children: analysis of 16 years' experience and clinical practice","volume":"159","author":"Kinsler VA","year":"2008","journal-title":"Br J Dermatol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/archderm.140.2.171","article-title":"Number of satellite nevi as a correlate for neurocutaneous melanocytosis in patients with large congenital melanocytic nevi","volume":"140","author":"Marghoob AA","year":"2004","journal-title":"Arch Dermatol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jaad.2006.03.008","article-title":"Large congenital melanocytic nevi, risk of cutaneous melanoma, and prophylactic surgery","volume":"54","author":"Marghoob AA","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jaad.2006.03.005","article-title":"Management of large congenital melanocytic nevi: art versus science","volume":"54","author":"Kanzler MH","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/SAP.0b013e318095a784","article-title":"An 18-year experience in the management of congenital nevomelanocytic nevi","volume":"60","author":"Warner P","year":"2008","journal-title":"Ann Plast Surg"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00006534-200109010-00004","article-title":"Giant congenital nevi: a 20-year experience and an algorithm for their management","volume":"108","author":"Gosain AK","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/00006534-199709001-00015","article-title":"Surgical treatment of large cutaneous lesions of the back in children by concentric cutaneous mobilization","volume":"100","author":"Chr\u00e9tien-Marquet B","year":"1997","journal-title":"Plast Reconstr Surg"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1590\/S1983-51752011000200004","article-title":"Tratamento cir\u00fargico do nevo melanoc\u00edtico gigante","volume":"26","author":"Carneiro LVFJ","year":"2011","journal-title":"Rev Bras Cir Plast"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archderm.132.1.20","article-title":"Neonatal curettage of giant congenital melanocytic nevi","volume":"132","author":"De Raeve LE","year":"1996","journal-title":"Arch Dermatol"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0007-1226(87)90046-4","article-title":"Congenital \"giant\" naevus: a preliminary report of a new surgical approach","volume":"40","author":"Moss AL","year":"1987","journal-title":"Br J Plast Surg"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/028443100750059093","article-title":"Dermabrasion of large congenital melanocytic naevi in 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